Recent Publications (last 5 years)



J. Christmann, P. Cao, J. Becker, C.K. Desiderato, O. Goldbeck, C.U. Riedel, M. Kohlstedt, C. Wittmann. High-efficiency production of the antimicrobial peptide pediocin PA-1 in metabolically engineered Corynebacterium glutamicum using a microaerobic process at acidic pH and elevated levels of bivalent calcium ions. Microb Cell Fact. 2023 Feb 27;22(1):41. doi: 10.1186/s12934-023-02044-y.

E. Pashou, S.J. Reich, A. Reiter, D. Weixler, B.J. Eikmanns, M. Oldiges, C.U. Riedel*, O. Goldbeck. Identification and Characterization of Corynaridin, a Novel Linaridin from Corynebacterium lactis. Microbiol Spectr. 2023 Feb 14;11(1):e0175622. doi: 10.1128/spectrum.01756-22. * corresponding author



C.K. Desiderato, K.M. Hasenauer, S.J. Reich, O. Goldbeck, L. Holivololona, K.V. Ovchinnikov, A. Reiter, M. Oldiges, D.B. Diep, B.J. Eikmanns, C.U. Riedel. Garvicin Q: characterization of biosynthesis and mode of action. Microb Cell Fact. 2022 Nov 11;21(1):236. doi: 10.1186/s12934-022-01952-9.

V. Vogel V, L.R. Olari, M. Jachmann, S.J. Reich, M. Häring, A.K. Kissmann, F. Rosenau, C.U. Riedel, J. Münch, B. Spellerberg. The bacteriocin Angicin interferes with bacterial membrane integrity through interaction with the mannose phosphotransferase system. Front Microbiol. 2022 Sep 6;13:991145. doi: 10.3389/fmicb.2022.991145.

A. Suwandi, K.G. Alvarez, A. Galeev, N. Steck, C.U. Riedel, J.L. Puente, J.F. Baines, G.A. Grassl. B4galnt2-mediated host glycosylation influences the susceptibility to Citrobacter rodentium infection. Front Microbiol. 2022 Aug 11;13:980495. doi: 10.3389/fmicb.2022.980495.

K.V. Ovchinnikov, T.F. Oftedal, S.J. Reich, N.S. Bar, H. Holo, M. Skaugen, C.U. Riedel, D.B. Diep. Genome-assisted Identification, Purification, and Characterization of Bacteriocins. Bio-protocol 2022; 12(14):e4477. doi: 10.21769/BioProtoc.4477

S.J. Reich, J. Stohr, O. Goldbeck, B. Fendrich, P. Crauwels, C.U. Riedel. Improved fluorescent Listeria spp. biosensors for analysis of antimicrobials by flow cytometry. MicrobiologyOpen 2022 Aug;11(4):e1304. doi: 10.1002/mbo3.1304D.

Weixler, M. Berghoff, K.V. Ovchinnikov, S. Reich, O. Goldbeck, G.M. Seibold, C. Wittmann, N.S. Bar, B.J. Eikmanns, D.B. Diep, C.U. Riedel. Recombinant production of the lantibiotic nisin using Corynebacterium glutamicum in a two-step process. Microb Cell Fact. 2022 Jan 15;21(1):11. doi: 10.1186/s12934-022-01739-y.

H. Melhem, B. Kaya, T. Kaymak, P. Wuggenig, E. Flint, J. Roux, K.C. Oost, C. Cavelti-Weder, M.L. Balmer, J.C. Walser, R.A. Morales, C.U. Riedel, P. Liberali, E.J. Villablanca, J.H. Niess. Epithelial GPR35 protects from Citrobacter rodentium infection by preserving goblet cells and mucosal barrier integrity. Mucosal Immunol. 2022 Mar;15(3):443-458. doi: 10.1038/s41385-022-00494-y.



T.F. Oftedal, K. Ovchinnikov, K.A. Hestad, O. Goldbeck, D. Porcellato, J. Narvhus, C.U. Riedel, M. Kjos, D.B. Diep. Ubericin K, a New Pore-Forming Bacteriocin Targeting Mannose-PTS. Microbiol Spectr. 2021 Oct 31;9(2):e0029921. doi: 10.1128/Spectrum.00299-21.

O. Goldbeck, D.N. Desef, K.V. Ovchinnikov, F. Perez-Garcia, J. Christmann, P. Sinner, P. Crauwels, D. Weixler, P. Cao, J. Becker, M. Kohlstedt, J. Kager, B.J. Eikmanns, G.M. Seibold, C. Herwig, C. Wittmann, N.S. Bar, D.B. Diep, C.U. Riedel. Establishing recombinant production of pediocin PA-1 in Corynebacterium glutamicum. Metabolic Engineering. 2021 Sep 4:S1096-7176(21)00141-5. doi: 10.1016/j.ymben.2021.09.002.

C.K. Desiderato, S. Sachsenmaier, K.V. Ovchinnikov, J. Stohr, S. Jacksch, D.N. Desef, P. Crauwels, M. Egert, D.B. Diep, O. Goldbeck, C.U. Riedel. Identification of Potential Probiotics Producing Bacteriocins Active against Listeria monocytogenes by a Combination of Screening Tools. International Journal of Molecular Sciences. 2021 Aug 10;22(16):8615. doi: 10.3390/ijms22168615.

D. Weixler, O. Goldbeck, G.M. Seibold, B.J. Eikmanns, C.U. Riedel. Towards improved resistance of Corynebacterium glutamicum against nisin. bioRxiv. 2021.08.09.454123. doi: 10.1101/2021.08.09.454123

B. Nikparvar, A. Subires, M. Capellas, M. Hernandez-Herrero, P. Crauwels, C.U. Riedel, N. Bar. A Diffusion Model to Quantify Membrane Repair Process in Listeria monocytogenes Exposed to High Pressure Processing Based on Fluorescence Microscopy Data. Frontiers in Microbiology. 2021 May 13;12:598739. doi: 10.3389/fmicb.2021.598739.

I.C. Duru, F.I. Bucur, M. Andreevskaya, A. Ylinen, P. Crauwels, L. Grigore-Gurgu, B. Nikparvar, T.M. Rode, P. Laine, L. Paulin, T. Løvdal, C.U. Riedel, N. Bar, D. Borda, A.I. Nicolau, P. Auvinen. The complete genome sequence of Listeria monocytogenes strain S2542 and expression of selected genes under high-pressure processing. BMC Res Notes. 2021 Apr 15;14(1):137. doi: 10.1186/s13104-021-05555-2.

B. Nikparvar, M. Andreevskaya, I.C. Duru, F.I. Bucur, L. Grigore-Gurgu, D. Borda, A.I. Nicolau, C.U. Riedel, P. Auvinen, N. Bar. Analysis of temporal gene regulation of Listeria monocytogenes revealed distinct regulatory response modes after exposure to high pressure processing. BMC Genomics. 2021 Apr 14;22(1):266. doi: 10.1186/s12864-021-07461-0.

O. Goldbeck, D. Weixler, B.J. Eikmanns, C.U. Riedel. In Silico Prediction and Analysis of Unusual Lantibiotic Resistance Operons in the Genus Corynebacterium. Microorganisms. 2021 Mar 19;9(3):646. doi: 10.3390/microorganisms9030646.

V. Palmieri, J.-F. Ebel, N. Ngo Thi Phuong, R. Klopfleisch, V. Pham Vu, A. Adamczyk, J. Zöller, C. Riedel, J. Buer, P. Krebs, W. Hansen, E. Pastille, A.M. Westendorf. Interleukin-33 signaling exacerbates experimental infectious colitis by enhancing gut permeability and inhibiting protective Th17 immunity. Mucosal Immunol. 2021 Jul;14(4):923-936. doi: 10.1038/s41385-021-00386-7.

I.C. Duru, F.I. Bucur, M. Andreevskaya, B. Nikparvar, A. Ylinen, L. Grigore-Gurgu, T.M. Rode, P. Crauwels, P. Laine, L. Paulin, T. Løvdal, C.U. Riedel, N. Bar, D. Borda, A.I. Nicolau, P. Auvinen. High-pressure processing-induced transcriptome response during recovery of Listeria monocytogenes. BMC Genomics. 2021 Feb 12;22(1):117. doi: 10.1186/s12864-021-07407-6.



I.C. Duru, M. Andreevskaya, P. Laine, T.M. Rode, A. Ylinen, T. Løvdal, N. Bar, P. Crauwels, C.U. Riedel, I.F. Bucur, A. Nicolau, P. Auvinen. Genomic characterization of the most barotolerant Listeria monocytogenes RO15 strain compared to reference strains used to evaluate food high pressure processing. BMC Genomics. 2020 Jul 2;21(1):455. doi: 10.1186/s12864-020-06819-0.



E. Herdoiza Padilla, P. Crauwels, T. Bergner, N. Wiederspohn, S. Förstner, R. Rinas, A. Ruf, M. Kleemann, R. Handrick, J. Tuckermann, K. Otte, P. Walther, C.U. Riedel.  mir-124-5p Regulates Phagocytosis of Human Macrophages by Targeting the Actin Cytoskeleton via the ARP2/3 Complex. Front Immunol. 2019 Oct 4;10:2210. doi: 10.3389/fimmu.2019.02210

C. Conzelmann, M. Zou, R. Groß, M. Harms, A. Röcker, C.U. Riedel, J. Münch, J.A. Müller. Storage-Dependent Generation of Potent Anti-ZIKV Activity in Human Breast Milk. Viruses. 2019 Jun 28;11(7). pii: E591. doi: 10.3390/v11070591.

M. Zetzmann, F.I. Bucur, P. Crauwels, D. Borda, A.I. Nicolau, L. Grigore-Gurgu, G.M. Seibold, C.U. Riedel. Characterization of the biofilm phenotype of a Listeria monocytogenes mutant deficient in agr peptide sensing. Microbiology Open. 2019 Mar 6:e826. doi: 10.1002/mbo3.826.

M. Kleemann, H.  Schneider, K. Unger, J. Bereuther, S. Fischer, P. Sander, M.E. Schneider, P. Fischer-Posovszky, C.U. Riedel, R. Handrick, K. Otte. Induction of apoptosis in ovarian cancer cells by miR-493-3p directly targeting AKT2, STK38L, HMGA2, ETS1 and E2F5. Cell Mol Life Sci. 2019 Feb;76(3):539-559. doi: 10.1007/s00018-018-2958-x.




P. Crauwels, L. Schäfer, D. Weixler, N.S. Bar, D.B. Diep, C.U. Riedel*, G.M. Seibold. Intracellular pHluorin as sensor for easy assessment of bacteriocin-induced membrane-damage in Listeria monocytogenes. Front Microbiol. 2018 Dec 11. doi: 0.3389/fmicb.2018.03038. * corresponding author

F.I. Bucur, L. Grigore-Gurgu, P. Crauwels, C.U. Riedel, A.I. Nicolau. Resistance of Listeria monocytogenes to Stress Conditions Encountered in Food and Food Processing Environments. Front Microbiol. 2018. Nov 13. doi: 10.3389/fmicb.2018.02700.

E. Herrmann, W. Young, V. Reichert-Grimm, S. Weis, C.U. Riedel, D. Rosendale, H. Stoklosinski, M. Hunt, M. Egert. In Vivo Assessment of Resistant Starch Degradation by the Caecal Microbiota of Mice Using RNA-Based Stable Isotope Probing-A Proof-of-Principle Study. Nutrients. 2018 Feb 6;10(2). pii: E179. doi: 10.3390/nu10020179.



Further selected publications

M. Zetzmann, A. Sánchez-Kopper, M.S. Waidmann, B. Blombach, C.U. Riedel. Identification of the agr Peptide of Listeria monocytogenes. Front Microbiol. 2016 Jun 22;7:989.

M. Zetzmann, M. Okshevsky, J. Endres, A. Sedlag, N. Caccia, M. Auchter, M.S. Waidmann, M. Desvaux, R.L. Meyer, C.U. Riedel. DNase-Sensitive and -Resistant Modes of Biofilm Formation by Listeria monocytogenes. Front. Microbiol. 2015 Dec 22;6:1428.

A. Osswald, Z. Sun, V. Grimm, G. Ampem, K. Riegel, A.M. Westendorf, W. Sommergruber, K. Otte, P. Dürre, C.U. Riedel. Three-dimensional tumor spheroids for in vitro analysis of bacteria as gene delivery vectors in tumor therapy. Microb Cell Fact. 2015 Dec 12;14(1):199.

Z. Sun, V. Grimm, C.U. Riedel. AI-2 to the rescue against antibiotic-induced intestinal dysbiosis? Trends Microbiol. 2015 Jun;23(6):327-8.

V. Grimm, M. Gleinser, C. Neu, D. Zhurina, C.U. Riedel. Expression of fluorescent proteins in bifidobacteria for analysis of host-microbe interaction. Appl Environ Microbiol. 2014 May;80(9):2842-50.

Z. Sun, A. Baur, D. Zhurina, J. Yuan, C.U. Riedel. Accessing the inaccessible: molecular tools for bifidobacteria. Appl Environ Microbiol. 2012 Aug;78(15):5035-42.

M. Gleinser, V. Grimm, D. Zhurina, J. Yuan, C.U. Riedel. Improved adhesive properties of recombinant bifidobacteria expressing the Bifidobacterium bifidum-specific lipoprotein BopA. Microb Cell Fact. 2012 Jun 13;11:80.

C.U. Riedel, I.R. Monk, P.G. Casey, M.S. Waidmann, C.G.M. Gahan, and C. Hill. AgrD-dependent quorum sensing affects biofilm formation, invasion, virulence and global gene expression profiles in Listeria monocytogenes. Mol Microbiol. 2009 Mar;71(5):1177-89.

C.U. Riedel, P. Casey. H. Mulcahy, F. O’Gara, C.G.M. Gahan, and C. Hill. Construction of p16Slux, a novel vector for improved bioluminescent-labelling of Gram-negative bacteria. Appl Environ Microbiol. 2007 Nov;73(21):7092-5.

S.C. Corr, Y. Li, C.U. Riedel, P.W. O’Toole, C. Hill, and C.G.M. Gahan. Bacteriocin production as a mechanism for the anti-infective activity of a probiotic bacterium. Proc Nat Acad Sci USA. 2007 May 1;104(18):7617-21.

C.U. Riedel, I.R. Monk, P. Casey, D. Morrissey, G.C. O’Sullivan, M. Tangney, C. Hill and C.G.M. Gahan. An improved luciferase tagging system for Listeria monocytogenes allows real-time monitoring in vivo and in vitro. Appl Environ Microbiol. 2007 May;73(9):3091-4.

C. Riedel, D. Rittmann, P. Dangel, B. Möckel, S. Petersen, H. Sahm, and B.J. Eikmanns. Characterisation of the phosphoenolpyruvate-carboxykinase gene from Corynebacterium glutamicum and significance of the enzyme for growth and amino acid production. J Mol Microbiol Biotechnol. 2001 Oct;3(4):573-83.

S. Petersen, C. Mack, A. A. de Graaf, C. Riedel, B.J. Eikmanns, and H. Sahm. Anaplerotic substrate cycling in Corynebacterium glutamicum: metabolic consequences of phosphoenolpyruvate carboxykinase activity and inference to anaplerotic regulation in vivo. Metab Eng. 2001 Oct;3(4):344-61.