The team of Prof. Dr. J. Tuckermann was able to publish important research results in collaboration with other european partners in the prestigious journal Nature Communications:
Vettorazzi S, Bode C, Dejager L, Frappart L, Shelest E, Klaßen C, Tasdogan A, Reichardt HM, Libert C, Schneider M, Weih F, Henriette Uhlenhaut N, David JP, Gräler M, Kleiman A, Tuckermann JP. Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1. Nat Commun. 2015 Jul 17;6
Abstract:
Endothelial damage is a major component of acute lung injury pathogenesis that occurs also in trauma. The authors could show that in acute lung injury, glucocorticoids induce sphingosine kinase 1 production in macrophages, promoting endothelial barrier function and ameliorating the disease. Most importantly they demonstrate that synergistic signaling by pro-inflammatory pathways in concert with the Glucocorticoid receptor is essential for anti-inflammatory efficacy of glucocorticoids.This novel mechanism shall be considered for the development of optimized anti-inflammatory strategies.