Andreas Riegger
Office: O25/356
Tel: 0049-731-50-22889
Supervisor- Prof. Dr. Tanja Weil
Title: Development of novel drug delivery systems based on dendritic structures
Research Description
Dendrimers are exemplifications of precision synthetic macromolecules since they have a highly defined structure, are monodisperse, multivalent, spherical and show a high density of functional groups on the surface. Notably, these molecules consist of a core, an inner and an outer shell. Each of these structural components can be modified to tune the properties such as thermal and chemical stability, solubility and toxicity to cater for a broad range of applications.
The high drug load and solubility of the resulting molecules is also an advantage in comparison to common drug delivery systems. Thus, the aim of my project is to use supramolecular and bioorthogonal reactions for the development of novel drug delivery systems based on dendritic structures. For this purpose, different drugs, (signal) peptides, proteins and fluorescent markers will be attached to the outer shell of the branched structures and the biological activity will be investigated.