Original publications

Herrmann F*, Bundschu K*, Kühl SJ, Kühl M (2011) Tbx5 overexpression favours a first heart field lineage in murine embryonic stem cells and in Xenopus laevis embryos, Dev. Dyn., 240, 2634-45, * both contributed equally

Tao S, Kühl M, Kühl SJ (2011) Expression of periostin during Xenopus laevis embryogenesis, Dev. Genes Evol., 221, 247-54

Tecza A, Bugner V, Kühl M, Kühl SJ (2011) Pes1 and ppan function during Xenopus laevis pronephros development, Biol. Cell, 103, 483-98, cover image

Bugner V, Aurhammer T and Kühl M (2011) Xenopus laevis insulin receptor substrate IRS-1 is important for eye development, Dev. Dyn., 240, 17-15

Guo Y, Christine KS, Conlon F, Gessert S, Kühl M (2011) Expression analysis of epb41l4a during Xenopus laevis embryogenesis, Dev. Genes Evol., 221, 118-9

Maucher M*, Kracher B*, Kühl M, Kestler H (2011) Inferring Boolean network structure via correlation, Bioinformatics, 27, 1529-36, * both contributed equally

Bugner V, Tecza A, Gessert S, Kühl M (2011) Peter Pan functions independent of its role in ribosome biogenesis during early eye and craniofacial cartilage development in Xenopus laevis, Development, 138, 2369-78

Gessert S, Schmeisser MJ, Tao S, Böckers TM, Kühl M (2011) The spatio-temporal expression of ProSAP/Shank family members and their interaction partner LAPSER1 during Xenopus laevis development, Dev. Dyn., 240, 1528-36

Tata RP, Tata NR, Kühl M, Sirbu IO (2011) Identification of a novel epigenetic regulatory region within the pluripotency associated microRNA cluster, EEmiRC, Nucleic Acids Res., 39, 3574-81

Evron T, Philipp M, Lu J, Meloni AR, Burkhalter M, Chen W and Caron MG (2011) Growth arrest specific 8 (Gas8) and GPCR kinase 2 (GRK2) cooperate in the control of smoothenend signaling, J. Biol. Chem. 286, 27676-86

Soderblom EJ, Philipp M, Thompson JW, Caron MG and Moseley MA (2011) A quantitative label-free phosphoproteomics strategy for mulitfaceted experimental designs, Anal. Chem., 83,3758-64

Ullrich M, Bundschu K, Benz PM, Abesser M, Freudinger R, Fischer T, Ullrich J, Renne T, Walter U, Schuh K (2011) Identification of Sprouty-related protein with EVH-1 domain (SPRED) 2 as a negative regulator of the Hypothalamic-Pituitary-Adrenal (HPA) axis, J Biol Chem, 286, 9477-88

Wacker SA, Alvarado C, von Wichert G, Knippschild U, Wiedenmann J, Clauss K, Nienhaus GU, Hameister H, Baumann B, Borggrefe T, Knöchel W and Oswald F (2011) RITA, a novel modulator of Notch signalling, acts via nuclear export of RBP-J. EMBO J. 30, 43-56

Schmidt J, Schuff M, Olsson L (2011) A role for FoxN3 in the development of cranial cartilages and muscles in Xenopus laevis, J. Anat. 218, 226-42

Klein C, Mikutta J, Krueger J, Scholz K, Brinkmann J, Liu D, Veerkamp J, Siegel D, Abdelila-Seyfried S, le Noble F (2011) Neuron navigator 3a regulates liver organogenesis during zebrafish embryogenesis, Development 138, 1935-45


Kühl SJ and Kühl M (2011) Improving cardiac function after injury: are we a step closer? BioEssays, 33, 669-73

Kestler HA and Kühl M (2011) Generating a Wnt switch: it´s all about the right dosage, JCB, 193, 431-3


Original publications

Gessert S, Bugner V, Tecza A, Pinker M, Kühl M (2010) FMR1/FXR1 and the miRNA pathway are required for eye and neural crest development, Dev. Biol., 341, 222-35

Tuduce I, Schuh K, Bundschu K (2010) SPRED2 expression during mouse development, Dev. Dyn., 239, 3072-85

Cao Y, Oswald F, Wacker S, Bundschu K, Knöchel W (2010) Reversal of xenopus OCT25 function by disruption of the pou doman structure, J Biol Chem, 285, 8408-21

Schuff M, Siegel D, Bardine N, Oswald F, Donow C and Knöchel W (2010) FoxO genes are dispensable during gastrulation but required for late embryogenesis in Xenopus laevis. Dev. Biol. 337, 259-273


Gessert S and Kühl M (2010) The multiple phases and faces of Wnt signaling during cardiac differentiation and development, Circ. Res., 107, 186-99

Rao TP and Kühl M (2010) An updated overview of Wnt signaling pathways: a prelude for more, Circ. Res., 106, 1798-806

Durston AJ, Jansen HJ and Wacker SA (2010) Time-space translation: a developmental principle. ScientificWorldJournal. 10, 2207-2214

Durston AJ, Jansen HJ and Wacker SA (2010) Review: Time-space translation regulates trunk axial patterning in the early vertebrate embryo. Genomics 95(5), 250-255

Text books

Kühl M und Gessert S (2010) Entwicklungsbiologie, UTB Basics, Eugen Ulmer Verlag, Stuttgart


Original publications

Gessert S and Kühl M (2009) Comparative gene expression analysis and fate mapping studies suggest an early segregation of cardiogenic lineages in Xenopus laevis, Dev. Biol. 334, 395-408

Mann T, Bodmer R, Pandur P (2009) The Drosophila homolog of vertebrate Islet1 is a key component in early cardiogenesis, Development, 136, 317-26

Zhao X, Sirbu IO, Mic FA, Molotkov A, Kumar S, Duester G (2009) Retinoic acid promotes limb induction through effects on body axis extension but is unnecessary for limb patterning. Curr. Biol., 19,1050-7

Woltering JM, Vonk FJ, Müller H, Bardine N, Tuduce IL, de Bakker MA, Knöchel WP, Sirbu IO, Durston AJ, Richardson MK (2009) Axial patterning in snakes and caecilians: Evidence for alternative interpretation of the Hox code. Dev. Biol., 332,82-9

Siegel D, Schuff M, Oswald F, Cao Y and Knöchel W (2009) Functional dissection of XDppa2/4 structural domains in Xenopus development. Mech. Dev. 126, 974-989

Bardine N, Donow C, Korte B, Durston AJ, Knöchel W and Wacker SA (2009) Two Hoxc6 transcripts are differentially expressed and regulate primary neurogenesis in Xenopus laevis. Dev. Dyn. 238, 755-765


Sirbu IO and Pandur P (2009) Saving hearts through basic research. Birth Defects Res C Embryo Today 87, 273-283


Original publications

Gessert S, Maurus D, Brade T, Walther P, Pandur P, Kühl M (2008) DM-GRASP/ALCAM/CD166 is required for cardiac morphogenesis and maintenance of cardiac identity in first heart field derived cells, Dev. Biol. 321, 150-61

Gessert S, Maurus D, Kühl M (2008) Repulsive guidance molecule A (RGM A) and its receptor Neogenin during neural and neural crest development of Xenopus laevis, Biol. Cell, 100, 659-73, cover image

Sirbu IO, Zhao X, Duester G (2008) Retinoic acid controls heart anteriorposterior patterning by downregulating Isl1 through the Fgf8 pathway. Dev. Dyn., 237,1627-35

Cao Y, Siegel D, Oswald F and Knöchel W (2008) Oct25 represses transcription of nodal/activin target genes by interaction with signal transducers during Xenopus gastrulation. J. Biol. Chem. 283, 34168-34177

Luu O, Nagel M, Wacker S, Lemaire P and Winklbauer R (2008) Control of gastrula cell motility by the Goosecoid/Mix.1/ Siamois network: basic patterns and paradoxical effects. Dev. Dyn. 237, 1307-1320

Yuan L, Cao Y, Oswald F and Knöchel W (2008) IRE1beta is required for mesoderm formation in Xenopus embryos. Mech. Dev. 125, 207-222


Kestler HA, Wawra C, Kracher B, Kühl M (2008) Network modeling of signal transduction: establishing of a global view, BioEssays, 30, 1110-25

Kestler HA, Kühl M (2008) From individual Wnt pathways towards a Wnt signalling network, Phil. Trans. R. Soc. B, 363, 1333-47

Book chapters

Kühl M, Pandur P (2008) Dorsal axis duplication as a functional read-out for Wnt acitivity, Ed: Vincan E. Humana Press Inc., New Jersey, USA

Kühl M,  Pandur P (2008) Measuring CamKII activity in Xenopus embryos as a read-out for non-canonical Wnt signaling, Ed: Vincan E. Humana Press Inc., New Jersey, USA


Original publications

Anton R, Kestler HA, Kühl M (2007) β-catenin signalling contributes to stemness and regulates differentiation in murine embryonic stem cells, FEBS Letters 581, 5247-5254

Gessert S*, Maurus D*, Rössner A, Kühl M (2007) Pescadillo is required for Xenopus laevis eye and neural crest development, Dev. Biol. 310, 99-112, * both contributed equally

Brade T, Gessert S, Kühl M, Pandur P (2007) The amphibian second heart field: Xenopus islet-1 is required for cardiovascular development, Dev. Biol. 311, 297-310

Wawra C, Kühl M, Kestler HA (2007) Extended analyses of the Wnt/beta-catenin pathway: robustness and oscillatory behavior, FEBS Lett, 581, 4043-8

Giamas G, Shoshiashvili L, Hirner H, Grithey A, Gessert S, Kühl M, Henne-Bruns D, Vorgias CE, Knippschild U (2007) Phosphorylation of CKIδ by PKA, Akt, CLK2 and PKC: Identification of Ser370 as the major phosphorylation site targeted by PKA in vitro and in vivo, Biochem. J. 406, 389-398

Schuff M, Rössner A, Wacker SA, Donow C, Gessert S, Knöchel W (2007) FoxN3 is required for craniofacial and eye development of Xenopus laevis, Dev. Dyn. 236, 226-39

Yuan L, Cao Y and Knöchel W (2007) Endoplasmic reticulum stress induced by tunicamycin disables germ layer formation in Xenopus laevis embryos. Dev. Dyn. 236, 2844-2851

Jansen HJ, Wacker SA, Bardine N and Durston AJ (2007) The role of the Spemann organizer in anterior-posterior patterning of the trunk. Mech. Dev. 124, 668-681

Cao Y, Siegel D, Donow C, Knöchel S, Yuan L and Knöchel W (2007) POU-V factors antagonize maternal VegT activity and beta-Catenin signaling in Xenopus embryos. EMBO J. 26, 2942-2954

Wacker SA, Oswald F, Wiedenmann J and Knöchel W (2007) A green to red photoconvertible protein as an analyzing tool for early vertebrate development. Dev. Dyn. 236, 473-480


Anton R, Kühl M, Pandur P (2007) A molecular signature of the master heart cell, BioEssays, 29,422-26

Bundschu K, Walter U, Schuh K (2007) Getting a first clue about SPRED functions, BioEssays 29, 897-907


Original publications

Cus R, Maurus D, Kühl M (2006) Cloning and developmental expression of WSTF during Xenopus laevis embryogenesis, Gen Expr. Patt 6, 340-346

Schön C, Wochnik A, Rössner A, Donow C and Knöchel W (2006) The FoxP subclass in Xenopus laevis development. Dev. Genes Evol. 216, 641-646

Cao Y, Siegel D and Knöchel W (2006) Xenopus POU factors of subclass V inhibit activin/nodal signaling during gastrulation. Mech. Dev. 123, 614-625

Schuff M, Rössner A, Donow C and Knöchel W (2006) Temporal and spatial expression patterns of FoxN genes in Xenopus laevis embryos. Int. J. Dev. Biol. 50, 429-434

Cao Y, Knöchel S, Oswald F, Donow C, Zhao H and Knöchel W (2006) XBP1 forms a regulatory loop with BMP-4 and suppresses mesodermal and neural differentiation in Xenopus embryos. Mech. Dev. 123, 84-96


Brade T, Männer J, Kühl M (2006) Wnt signaling during cardiac development and remodelling. Cardiovasc. Res., 72, 198-209

Quaiser T, Anton R, Kühl M (2006) Kinases and G proteins join the Wnt receptor complex. BioEssays, 128, 339-343

Bundschu K, Walter U, Schuh K (2006) The VASP-Spred-Sprouty domain puzzle, J Biol Chem 281, 36477-36481

Book chapters

Kühl M, Moon RT (2006) How to assay non-canonical Wnt signaling: A critical analysis, in: Analysis of growth factor signaling in embryos, pp 29-35, Ed.: Whitman M, Sater AK. CRC press, Francis & Taylor, Boca Raton, FL, USA


Original publications

Maurus D, Heligon C, Bürger-Schwärzler A, Brändli A, Kühl M (2005) Noncanonical Wnt-4 signaling and EAF2 are required for eye development in Xenopus laevis, EMBO J. 24, 1181-1181

Koyanagi M, Haendeler J, Badorff C, Brandes RP, Hoffmann J, Pandur P, Zeiher A, Kühl M, Dimmeler S (2005) Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells, J. Biol. Chem. 290, 16838-16842

Oswald F, Winkler M, Cao Y, Astrahantseff K, Bourteele S, Knöchel W and Borggrefe T (2005) RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol. Cell Biol. 25, 10379-10390

Pohl BS, Rössner A and Knöchel W (2005) The Fox gene family in Xenopus laevis:FoxI2, FoxM1 and FoxP1 in early development. Int. J. Dev. Biol. 49, 53-58


Pandur P (2005) What does it take to make a heart. Biol. Cell 97, 1-14

Pohl BS and Knöchel W (2005) Of Fox and Frogs: Fox (fork head/winged helix) transcription factors in Xenopus development. Gene. 344, 21-32.

Book chapters

Pandur P (2005) Recent discoveries in vertebrate non-canonical Wnt signaling: towards a Wnt signaling network. In: Mlodzik, M. (Ed.), Adv. Dev. Biol. Biochem. Elsevier, Vol.14


Original publications

Pandur PD, Dirksen ML, Moore KB, Moody SA (2004) Xenopus flotillin1, a novel gene highly expressed in the dorsal nervous system. Dev Dyn. 231, 881-887

Brugmann SA, Pandur PD, Kenyon KL, Pignoni F, Moody SA (2004) Six1 promotes a placodal fate within the lateral neurogenic ectoderm by functioning as both a transcriptional activator and repressor. Development 131, 5871-5881

Schön C, Köster M and Knöchel W (2004) A downstream enhancer is essential for Xenopus FoxD5 transcription. Biochem. Biophys. Res. Commun. 325, 1360-1366

Pohl BS, Schön C, Rossner A and Knöchel W (2004) The FoxO-subclass in Xenopus laevis development. Gene Expr. Patterns. 5, 187-192

Cao Y, Knöchel S, Donow C, Miethe J, Kaufmann E and Knöchel W (2004) The POU factor Oct-25 regulates the Xvent-2B gene and counteracts terminal differentiation in Xenopus embryos. J. Biol. Chem. 279, 43735-43743

Wacker SA, Jansen HJ, McNulty CL, Houtzager E and Durston AJ (2004) Timed interactions between the Hox expressing non-organiser mesoderm and the Spemann organiser generate positional information during vertebrate gastrulation. Dev. Biol. 268, 207-219

Pohl BS and Knöchel W (2004) Isolation and developmental expression of Xenopus FoxJ1 and FoxK1. Dev. Genes Evol. 214, 200-205

Durr U, Henningfeld KA, Hollemann, T, Knöchel W and Pieler T (2004) Isolation and characterization of the Xenopus HIVEP gene family. Eur. J. Biochem. 271, 1135-1144

Karaulanov E, Knöchel W and Niehrs C (2004) Transcriptional regulation of BMP4 synexpression in transgenic Xenopus. EMBO J. 23, 844-856

Wacker SA, McNulty CL and Durston AJ (2004) The initiation of Hox gene expression in Xenopus laevis is controlled by Brachyury and BMP-4. Dev. Biol. 266, 123-137


Maurus D, Kühl M (2004) Getting an embryo into shape. BioEssays, 26, 1272-1275

Kühl M (2004) The Wnt/calcium pathway: biochemical mediators, tools and future requirements. Front. Biosci. 9, 967-974

Text books

Linnemann M, Kühl M (2004) Biochemie für Mediziner, Springer Verlag Heidelberg, 7. Auflage (vorherige Auflagen: 2002, 1999, 1995, 1993, 1992, 1992)


Original publications

Sheldahl LC, Slusarski D, Pandur P, Miller J, Kühl M, Moon RT (2003) Dishevelled activates Ca2+ flux, PKC and CamKII signaling in vertebrate embryos, J. Cell Biol. 161, 769-777

Book chapters

Kühl M, ” Entwicklung und Altern” (2003) in: Lehrbuch Vorklinik (GK1), Hrsg: Unsicker, Schmidt, Fachhrsg: Birnbaumer, Kurtz, Schartl, Unsicker, Deutscher Ärzteverlag, C 575- 596

Hollemann T, Chen Y, Sölter M, Kühl M, Pieler T (2003) Embryonic explants from Xenopus laevis as an assay system to study differentiation of multipotent precursor cells, in: Cell biology: A Laboratory handbook, 3rd Ed., Ed: J.E. Celis, Elsevier Science, San Diego, USA

Behrens J, Kühl M (2003) Wnt signal transduction pathways: An overview. In: Kühl M (Editor): Wnt signalling in development, Landes Bioscience, Georgetown (Texas, USA), pp 1-14

Pandur P, Kühl M (2003) Wnt signalling in heart development. In: Kühl M (Editor): Wnt signalling in development, Landes Bioscience, Georgetown (Texas, USA), pp 170-183

Kaufmann E and Knöchel W (2003) Forkhead Domains. In: Cooper DN (ed.) Nature Encyclopedia of the Human Genome, vol. 2, pp. 519-523. London: Nature Publishing Group


Original publications

Schwarz-Romond T, Asbrand C, Bakkers J, Kühl M, Schaeffer HJ, Huelsken J, Behrens J, Hammerschmidt M, Birchmeier W (2002) The ankyrin repeat protein Diversin recruits Casein kinase l epsilon to the beta-catenin degradation complex and acts in both canonical Wnt and non-canonical Wnt/JNK signaling, Genes Dev. 15, 2073-84

Pandur P, Läsche M, Eisenberg L, Kühl M (2002) Wnt-11 stimulation of a non-canonical Wnt-pathway is required for cardiogenesis, Nature 418, 636-641

Hitz MP, Pandur P, Brand T, Kühl M (2002) Cardiac specific expression of Xenopus Popeye-1 (Pop-1). Mech. Dev. 115, 123-126

Martin B, Schneider R, Janetzky S, Waibler Z, Pandur P, Kühl M, Behrens J, von der Mark K, Starzinski-Powitz A, Wixler V (2002) The LIM-only protein FHL2 interacts with β-catenin and promotes differentiaion of mouse myoblasts. J. Cell Biol. 159, 113-122

Pandur PD, Sullivan SA, Moody SA (2002) Multiple maternal influences on dorsal-ventral fate of Xenopus animal blastomeres. Dev Dyn 225, 581-587

Oswald F, Kostezka U, Astrahantseff K, Bourteele S, Dillinger K, Zechner U, Ludwig L, Wilda M, Hameister H, Knöchel W, Liptay S and Schmid RM (2002) SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway. EMBO J. 21, 5417-5426

Pohl BS, Knöchel S, Dillinger K and Knöchel W (2002) Sequence and expression of FoxB2 (XFD-5) and FoxI1c (XFD-10) in Xenopus embryogenesis. Mech. Dev. 117, 283-287

Friedle H and Knöchel W (2002) Cooperative interaction of Xvent-2 and GATA-2 in the activation of the ventral homeobox gene Xvent-1B. J. Biol. Chem. 277, 23872-23881

Braun M, Wunderlin M, Spieth K, Knöchel W, Gierschik P and Moepps B (2002) Xenopus laevis Stromal cell-derived factor 1: conservation of structure and function during vertebrate development. J. Immunol. 168, 2340-2347

Pohl BS and Knöchel W (2002) Temporal and spatial expression patterns of FoxD2 during the early development of Xenopus laevis. Mech. Dev. 111, 181-184

Henningfeld KA, Friedle H, Rastegar S and Knöchel W (2002) Autoregulation of Xvent-2B; direct interaction and functional cooperation of Xvent-2 and Smad1. J. Biol. Chem. 277, 2097-2103


Kühl M (2002) Non-canonical Wnt signaling in Xenopus: regulation of axis formation and gastrulation. Sem. Cell Dev. Biol., 13, 243-249

Pandur P, Maurus D, Kühl M (2002) Increasingly complex: New players enter the Wnt signaling network. BioEssays 24, 881-885