Weidinger lab - open positions

PhD position “Mechanisms transforming generic injury responses to regeneration”

While adult mammals cannot replace amputated limbs, zebrafish can regenerate their fins. Our lab studies the cellular and molecular mechanisms underlying this astounding process (Sehring et al. 2022, elife; Mishra et al. 2020, Developmental Cell; Owlarn et al. 2017, Nature Communications; Wehner et al. 2014, Cell Reports; Knopf et al. 2011, Developmental Cell). Osteoblasts dedifferentiate and migrate to provide source cells for bone regeneration in the fin, but surprisingly, these early injury responses are only followed by regeneration at distal- but not proximal-facing injuries (Sehring et al. 2022, elife). One goal of this project is to uncover mechanisms that transform these early generic injury responses to genuine distally-oriented regeneration. In addition, interesting questions related to the function of NF-κB signaling in osteoblast dedifferentiation and the role of osteoblast-niche cell interactions in osteoblast injury responses remain to be answered. The successful PhD candidate will use state-of-the art in vivo experiments in zebrafish, including Cre-lox based transgenics and (single cell) RNASeq to address these topics.

We are looking for an enthusiastic, highly motivated scientist (f/m/d) who is dedicated to performing fundamental research.

We expect:

  • Training in developmental biology, molecular biology, cellular biology or related fields.
  • Enthusiasm for regenerative biology.
  • Excellent communication skills in spoken and written English.

We offer:

  • The opportunity to work in an international, dynamic and motivated team.
  • State-of-the art resources, including a 1000 tank zebrafish facility.
  • The possibility to join the international graduate school of Ulm University, iGradU.
  • Payment and benefits according to the collective agreement TV-L 13.

Further information about our lab can be found at www.uni-ulm.de/weidinger and twitter.com/WeidingerLab

Applications including a CV, a statement of research experience and interests (max. 2 pages), and contact data for 2-3 references should be emailed to Prof. Dr. Gilbert Weidinger, gilbert.weidinger(at)uni-ulm.de until 30.4.2023.