First-author Publications of our HEIST students:

Armacki M*, Polaschek S*, Waldenmaier M, Morawe M, Ruhland C, Schmid R, Lechel A, Tharehalli U, Steup C, Bektas Y, Li H, Kraus JM, Kestler HA, Kruger S, Ormanns S, Walther P, Eiseler T, Seufferlein T. (2020) Protein Kinase D1, Reduced in Human Pancreatic Tumours, Increases Secretion of Small Extracellular Vesicles From Cancer Cells That Promote Metastasis to Lung in Mice. Gastroenterology. S0016-5085(20)34705-3. doi: 10.1053/j.gastro.2020.05.052. * equal contribution.

Arnold F, Gout J, Wiese H, Weissinger S, Roger E, Perkhofer L, Walter K, Scheible J, Prelli-Bozzo C, Lechel A, Ettrich TJ, Azoitei N, Hao L, Fuerstberger A, Kaminska EK, Sparrer KMJ, Rasche V, Wiese S, Kestler HA, Möller P, Seufferlein T, Frappart PO*, Kleger A* (2021) RINT1 regulates SUMOylation and the DNA damage response to preserve cellular homeostasis in pancreatic cancer. Cancer Res. doi: 10.1158/0008-5472.CAN-20-2633.

Arnold F, Mahaddalkar PU, Kraus JM, Zhong X, Bergmann W, Srinivasan D, Gout J, Roger E, Beutel AK, Zizer E, Tharehalli U, Daiss N, Russell R, Perkhofer L, Oellinger R, Lin Q, Azoitei N, Weiss FU, Lerch MM, Liebau S, Katz SF, Lechel A, Rad R, Seufferlein T, Kestler HA, Ott M, Sharma AD, Hermann PC*, Kleger A* (2021) Functional genomic screening during somatic cell reprogramming identifies Dkk3 as a roadblock of organ regeneration. Adv. Sci. doi: 10.1002/advs.202100626.

Beccard I, Hofmann L, Schroeder JC, Ludwig S, Laban S, Brunner C, Lotfi R, Hoffmann TK, Jackson EK, Schuler PJ, Theodoraki NN (2020). Immune Suppressive Effects of Plasma-Derived Exosome Populations in Head and Neck Cancer. Cancers. 12(7), 1997, doi.org/10.3390/cancers12071997

Dugge R, Kreipe H, Rosenwald A, Lehmann U, Möller P, Barth TFE, Erlemann R. Coincidence of lymphomatoid granulomatosis, chronic myelomonocytic leukemia, and anaplastic T cell lymphoma after methotrexate therapy for rheumatoid arthritis. (2020) Ann Hematol. 98(2):515-517. doi: 10.1007/s00277-018-3434-2.

Dugge R, Wagener R, Mӧller P, Barth TF. Genome-wide DNA Methylation Analysis along the Progression of Gastric Marginal Zone B-cell Lymphoma of MALT Type. British Journal of Hematology (in press)

Hageb A, Thalheim T, Nattamai KJ, Möhrle B, Saçma M, Sakk V, Thielecke L, Cornils K, Grandy C, Port F, Gottschalk K-E, Mallm J-P, Glauche I, Galle J, Mulaw MA, Geiger H. Reduced adhesion of aged intestinal stem cells contributes to an accelerated clonal drift. Life Science Alliance Apr 2022, 5 (8) e202201408; DOI: 10.26508/lsa.202201408.

Ihle M, Biber S, Schroeder IS, Deniz M, Damia G, Gottifredi V, Wiesmüller L (2021) Impact of the Interplay between Stemness Features, p53 and Pol iota on Replication Pathway Choices. Nucleic Acids Res 2021 Jul 21;49(13):7457-7475. doi: 10.1093/nar/gkab526.

Lausser L.*, Schäfer L.M.*, Kestler H.A. Ordinal classifiers can fail on repetitive class structure. (2018) Archives of Data Science, 4(1). *equal contribution

Lausser L.*, Schäfer L.M.*, Kühlwein S.D., Kestler A.M.R., Kestler H.A. Detecting ordinal subcascades. (2020). Neural Processing Letters, 52: 2583-2605. *equal contribution

Lausser L*, Schäfer LM*, Schirra LR, Szekely R, Schmid F, Kestler HA (2019) Assessing phenotype order in molecular data. Scientific Reports, 9(11746), *equal contribution.

Laut AK, Dorneburg C, Fürstberger A, Barth TFE, Kestler HA, Debatin KM, Beltinger C (2021) CHD5 inhibits metastasis of neuroblastoma. Oncogene. 2022 Jan;41(5):622-633. Epub 2021 Nov 17. PMID: 34789839; PMCID: PMC8799470. https://doi.org/10.1038/s41388-021-02081-0.

Leinauer B, Hild V, Giesche JP, Breining T, Lübbehüsen C, Lüke J, Hasenfratz M, Mellert K, von Baer A, Schultheiss M, Möller P, Barth TFE (2020) Giant Cell Tumor of Bone – new aspects, new problems. Osteologie 29(1 // 01):91–6.

Mayer S, Schmidtke-Schrezenmeier G. , Buske Ch.,  Rücker F.G., Barth T.F.E.,  Möller P., Marienfeld R. (2020) Rescue of Non-Informative Circulating Tumor DNA to Monitor the Mutational Landscape in NSCLC. Cancers (Basel); 12(7):1917

Melzer MK*, Arnold F*, Stifter K, Zengerling F, Azoitei N, Seufferlein T, Bolenz C, Kleger A. An Immunological Glance on Pancreatic Ductal Adenocarcinoma. (2020) Int J Mol Sci.; 21(9):E3345. * equal contribution

Müller S*, Mayer S*, Möller P, Barth TFE, Marienfeld R. Spatial distribution of immune checkpoint proteins in histological subtypes of lung adenocarcinoma. Neoplasia. 2021 Jun;23(6):584-593. doi: 10.1016/j.neo.2021.05.005. Epub 2021 Jun 5.

Mytilineos D*, Ezic J*, von Witzleben A, Mytilineos J, Lotfi R, Furst D, Tsamadou C, Theodoraki MN, Oster A, Volkel G, Kestler HA, Brunner C, Schuler PJ, Doescher J, Hoffmann TK, Laban S. (2020) Peripheral Cytokine Levels Differ by HPV Status and Change Treatment-Dependently in Patients with Head and Neck Squamous Cell Carcinoma. Int J Mol Sci, 21(17):E5990.*equal contribution

Pan L, Hoffmeister P, Turkiewicz A, Huynh NND, Große-Berkenbusch A, Knippschild U, Gebhardt JCM, Baumann B, Borggrefe T, Oswald F. Transcription Factor RBPJL Is Able to Repress Notch Target Gene Expression but Is Non-Responsive to Notch Activation. Cancers (Basel). 2021 Oct 8;13(19):5027.

Spada F, Breining T, Barth TFE, Möller P. Diffuse large B-cell lymphoma in and of the bone. Forms and potential precursors. Osteologie 2021; 30: 99–106. Doi: 10.1055/a-1341-4991.

Spada F, Barth TFE, Möller P, Weißinger S. Gastric Marginal Zone B-cell Lymphoma of MALT type – an updated histo- and molecular pathological summary. Journal of Clinical and Experimental Gastroenterology 2022; 1(1):17-21. doi: 10.46439/gastro.1.004.

Seeling C, Hirte C, Scheuerle A, Möller P, Barth TFE. (2018) Presacral lesion at the rima ani. Pathologe 39(2): 181-185.

Tharehalli U, Svinarenko M, Kraus JM, Kühlwein SD, Szekely R, Kiesle U, Scheffold A, Barth TFE, Kleger A, Schirmbeck R, Kestler HA, Seufferlein T, Oswald F, Katz SF, Lechel A. (2018) YAP Activation Drives Liver Regeneration after Cholestatic Damage Induced by Rbpj Deletion. Int J Mol Sci. 19(12). pii: E3801. doi: 10.3390/ijms19123801.

Tharehalli U, Svinarenko M, Lechel A. Remodelling and Improvements in Organoid Technology to Study Liver Carcinogenesis in a Dish. (2019) Stem Cells Int. 2019:3831213. doi: 10.1155/2019/3831213.

 

Co-author Publications of our HEIST students:

Betzler AC, Ezić J, Abou Kors T, Hoffmann TK, Wirth T, Brunner C. T Cell Specific BOB.1/OBF.1 Expression Promotes Germinal Center Response and T Helper Cell Differentiation. Front Immunol. 2022 May 4;13:889564. doi: 10.3389/fimmu.2022.889564. PMID: 35603192; PMCID: PMC9114770.

Close V, Close W, Kugler SJ, Reichenzeller M, Yosifov DY, Bloehdorn J, Pan L, Tausch E, Westhoff MA, Döhner H, Stilgenbauer S, Oswald F, Mertens D. (2019) FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL. Blood.133(8):830-839. doi: 10.1182/blood-2018-09-874529.

Deniz M, Kaufmann J, Stahl A, Gundelach T, Janni W, Hoffmann I, Keimling M, Hampp S, Ihle M, Wiesmüller L. (2016) In vitro model for DNA double-strand break repair analysis in breast cancer reveals cell type-specific associations with age and prognosis. FASEB J.30:3786-3799.

Frappart PO, Walter K, Gout J, Beutel AK, Morawe M, Arnold F, Breunig M, Barth TF, Marienfeld R, Schulte L, Ettrich T, Hackert T, Svinarenko M, Rösler R, Wiese S, Wiese H, Perkhofer L, Müller M, Lechel A, Sainz B Jr, Herman PC, Seufferlein T, Kleger A. (2020) Pancreatic cancer-derived organoids – a disease modeling tool to predict drug response. United European Gastroenterol J, 8(5):594-606.

Gout J, Perkhofer P, Morawe M, Arnold F, Ihle M, Biber S, Lange S, Roger E, Kraus JM, K. Stifter, S, Hahn A, Zamperone A, Engleitner T, Müller M, Walter K, Rodriguez-Aznar E. Sainz B, Hermann P, Hessmann E, Müller S, Azoitei N, Lechel A, Liebau S, Wagner M, Simeone DM, Kestler HA, Seufferlein T, Wiesmüller L, Rad R, Frappart, PO, and Kleger, A. (2020) Synergistic targeting and resistance to PARP inhibition in DNA damage repair-deficient pancreatic cancer. Gut, :gutjnl-2019-319970. doi: 10.1136/gutjnl-2019-319970

Grünewald TG, Alonso M, Avnet S, Banito A, Burdach S, Cidre-Aranaz F, Di Pompo G, Distel M, Dorado-Garcia H, Garcia-Castro J, González-González L, Grigoriadis AE, Kasan M, Koelsche C, Krumbholz M, Lecanda F, Lemma S, Longo DL, Madrigal-Esquivel C, Morales-Molina Á, Musa J, Ohmura S, Ory B, Pereira-Silva M, Perut F, Rodriguez R, Seeling C, Al Shaaili N, Shaabani S, Shiavone K, Sinha S, Tomazou EM, Trautmann M, Vela M, Versleijen-Jonkers YM, Visgauss J, Zalacain M, Schober SJ, Lissat A, English WR, Baldini N, Heymann D. (2020) Sarcoma treatment in the era of molecular medicine. EMBO Mol Med. 2020 Oct 13;12(11):e11131. doi: 10.15252/emmm.201911131.

Gangkofner DS, Holzinger D, Schroeder L, Eichmüller SB, Zörnig I, Jäger D, Wichmann G, Dietz A, Broglie MA, Herold-Mende C, Dyckhoff G, Boscolo-Rizzo P, Ezic J, Marienfeld RB, Möller P, Völkel G, Kraus JM, Kestler HA, Brunner C, Schuler PJ, Wigand M, Theodoraki MN, Doescher J, Hoffmann TK, Pawlita M, Butt J, Waterboer T, Laban S. (2019) Patterns of antibody responses to nonviral cancer antigens in head and neck squamous cell carcinoma patients differ by human papillomavirus status. Int J Cancer, 145(12):3436-3444.

Jäger D, Lechel A, Tharehalli U, Seeling C, Möller P, Barth TFE, Mellert K. (2018) U-CH17P, -M and -S, a new cell culture system for tumor diversity and progression in chordoma. Int J Cancer;142(7):1369-1378. doi: 10.1002/ijc.31161.

Laban S, Gangkofner DS, Holzinger D, Schroeder L, Eichmüller SB, Zörnig I, Jäger D, Wichmann G, Dietz A, Broglie MA, Herold-Mende CC, Dyckhoff G, Boscolo-Rizzo P, Ezić J, Marienfeld R, Möller P, Kraus JM, Völkel G, Kestler HA, Brunner C, Schuler PJ, Wigand MC, Theodoraki MN, Doescher J, Hoffmann TK, Pawlita M, Waterboer T, Butt J. (2019) Antibody responses to cancer antigens identify patients with a poor prognosis among HPV-positive and HPV-negative head and neck squamous cell carcinoma patients. Clin Cancer Res. pii: clincanres.1490.2019.

Lübbehüsen C, Lüke J, Seeling C, Mellert K, Marienfeld R, von Baer A, Schultheiss M, Möller P, Barth, TFE (2019). Characterization of Three Novel H3F3A-mutated Giant Cell Tumor Cell Lines and Targeting of Their Wee1 Pathway. Sci Rep, 9(1), 6458.

Malka MM, Eberle J, Niedermayer K, Zlotos DP, Wiesmüller L (2021) Dual PARP and RAD51 Inhibitory Drug Conjugates Show Synergistic and Selective Effects on Breast Cancer Cells. Biomolecules, 11(7), 98, https://doi.org/10.3390/biom11070981.

Melzer MK, Arnold F, Stifter K, Zengerling F, Azoitei N, Seufferlein T, Bolenz C, Kleger A (2020) An Immunological Glance on Pancreatic Ductal Adenocarcinoma. Int J Mol Sci, 21(9):3345.

Muenzner JK, Kunze P, Lindner P, Polaschek S, Menke K, Eckstein M, Geppert CI, Chanvorachote P, Baeuerle T, Hartmann A, Schneider-Stock R. (2018). Generation and characterization of hepatocellular carcinoma cell lines with enhanced cancer stem cell potential. Journal of Cellular and Molecular Medicine, 22(12), 6238-6248

Perkhofer L, Schmitt A, Romero Carrasco MC, Ihle M, Hampp S, Ruess DA, Hessmann E, Russell R, Lechel A, Azoitei N, Lin Q, Liebau S, Hohwieler M, Bohnenberger H, Lesina M, Algül H, Gieldon L, Schröck E, Gaedcke J, Wagner M, Wiesmüller L, Sipos B, Seufferlein T, Reinhardt HC, Frappart PO, Kleger A. (2017) ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage. Cancer Res. 2017 Oct 15;77(20):5576-5590. doi: 10.1158/0008-5472.CAN-17-0634.

Perkhofer L*, Engler M*, Gout J, Arnold F, Morawe M, Breunig M, Seufferlein T, Kleger A, Frappart PO. (2019) Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks. Stem Cells Int.:2079742. doi: 10.1155/2019/2079742. eCollection 2019. *equal contribution

Roger E, Gout J, Arnold F, Beutel AK, Müller M, Abaei A, Barth TFE, Rasche V, Seufferlein T, Perkhofer L*, Kleger A*. (2020) Maintenance therapy for ATM-deficient pancreatic cancer by multiple DNA damage response interference after platinum-based chemotherapy. Cells. 2020 Sep 16;9(9):2110. doi: 10.3390/cells9092110.

Roth A, Gihring A, Bischof J, Pan L, Oswald F, Knippschild U. CK1 Is a Druggable Regulator of Microtubule Dynamics and Microtubule -Associated Processes. Cancers (Basel). 2022 Mar 5;14(5):1345.

Saçma M, Matteini F, Mulaw MA, Hageb A, Bogeska R, Sakk V, Vollmer A, Marka G, Soller K, Milsom MD, Florian MC, Geiger H. Fast and high-fidelity in situ 3D imaging protocol for stem cells and niche components for mouse organs and tissues. STAR Protoc. 2022 Jun 17;3(3):101483. doi: 10.1016/j.xpro.2022.101483. PMID: 35769923; PMCID: PMC9234157.

Schochter F, Werner K, Köstler C, Faul A, Tzschaschel M, Alberter B, Friedl TWP, Polzer BM, Janni W, Rack B, Wiesmüller L. (2020) 53BP1 Accumulation in Circulating Tumor Cells Identifies Chemotherapy Responsive Metastatic Breast Cancer Patients. Cancers;12(4):930.  doi: 10.3390/cancers12040930.

Schulte LA, Arnold F, Siegel F, Backhus J, Beyer G, Weiss FU, Perkhofer L, Beutel A, Seufferlein T, Müller M, Kleger A. (2020) Serum IgG4 levels outperform IgG4/IgG RNA ratio in differential diagnosis of IgG4-related disease. JHEP Rep, 2(4):100135.

Sperb, N, Tsesmelis, M, Wirth, T. (2020) Crosstalk between tumor and stromal cells in pancreatic ductal adenocarcinoma. Int.J.Mol.Sci., 21:5486.

Svinarenko M, Katz SF, Tharehalli U, Mulaw MA, Maier HJ, Sunami Y, Fischer SK, Chen Y, Heurich S, Erkert L, Tannapfel A, Wirth T, Schirmbeck R, Seufferlein T, Lechel A. (2019) An IKK/NF-κB activation/p53 deletion sequence drives liver carcinogenesis and tumor differentiation. Cancers (Basel);11(10). pii: E1410. doi: 10.3390/cancers11101410.

Weeber F, Becher A, Seibold T, Seufferlein T, Eiseler T. (2019). Concerted regulation of actin polymerization during constitutive secretion by cortactin and PKD2. J Cell Sci 132

von Witzleben A, Fehn A, Grages A, Ezić J, Jeske SS, Puntigam LK, Brunner C, Kraus JM, Kestler HA, Doescher J, Brand M, Theodoraki MN, Ottensmeier CH, Hoffmann TK, Schuler PJ, Laban S. Prospective longitudinal study of immune checkpoint molecule (ICM) expression in immune cell subsets during curative conventional therapy of head and neck squamous cell carcinoma (HNSCC) (2020) Int J Cancer, doi: 10.1002/ijc.33446.

Yuan Z, VanderWielen BD, Giaimo BD, Pan L, Collins CE, Turkiewicz A, Hein K, Oswald F, Borggrefe T, Kovall RA. (2019) Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site. Cell Rep. 26(4):845-854.e6. doi: 10.1016/j.celrep.2018.12.097.