HEIST Publications


First-author Publications of our HEIST students:

Dugge R, Kreipe H, Rosenwald A, Lehmann U, Möller P, Barth TFE, Erlemann R. Coincidence of lymphomatoid granulomatosis, chronic myelomonocytic leukemia, and anaplastic T cell lymphoma after methotrexate therapy for rheumatoid arthritis. (2020) Ann Hematol. 98(2):515-517. doi: 10.1007/s00277-018-3434-2. Epub 2018 Jul 7.

Schäfer L.M.*, Lausser L.*, Schirra L.R.*, Szekely R., Schmid F., Kestler H.A. Assessing phenotype order in molecular data. (2019) Sci Rep. (1):11746. doi: 10.1038/s41598-019-48150-z. (*equal contributors).

Armacki M*, Polaschek S*, Waldenmaier M, Morawe M, Ruhland C, Schmid R, Lechel A, Tharehalli U, Steup C, Bektas Y, Li H, Kraus JM, Kestler HA, Kruger S, Ormanns S, Walther P, Eiseler T, Seufferlein T. Protein Kinase D1, Reduced in Human Pancreatic Tumours, Increases Secretion of Small Extracellular Vesicles From Cancer Cells That Promote Metastasis to Lung in Mice. (2020) Gastroenterology. S0016-5085(20)34705-3. doi: 10.1053/j.gastro.2020.05.052. (*equal contributors).

Melzer MK*, Arnold F*, Stifter K, Zengerling F, Azoitei N, Seufferlein T, Bolenz C, Kleger A. An Immunological Glance on Pancreatic Ductal Adenocarcinoma. (2020) Int J Mol Sci.; 21(9):E3345. (*equal contributors)

Tharehalli U, Svinarenko M, Kraus JM, Kühlwein SD, Szekely R, Kiesle U, Scheffold A, Barth TFE, Kleger A, Schirmbeck R, Kestler HA, Seufferlein T, Oswald F, Katz SF, Lechel A. YAP Activation Drives Liver Regeneration after Cholestatic Damage Induced by Rbpj Deletion. (2018) Int J Mol Sci. 19(12). pii: E3801. doi: 10.3390/ijms19123801.

Tharehalli U, Svinarenko M, Lechel A. Remodelling and Improvements in Organoid Technology to Study Liver Carcinogenesis in a Dish. (2019) Stem Cells Int. 2019:3831213. doi: 10.1155/2019/3831213.


Co-author Publications of our HEIST students:

Perkhofer L*, Engler M*, Gout J, Arnold F, Morawe M, Breunig M, Seufferlein T, Kleger A, Frappart PO. Pancreatic Ductal Organoids React Kras Dependent to the Removal of Tumor Suppressive Roadblocks. Stem Cells Int. 2019 May 19;2019:2079742. doi: 10.1155/2019/2079742. eCollection 2019.

Laban S, Gangkofner DS, Holzinger D, Schroeder L, Eichmüller SB, Zörnig I, Jäger D, Wichmann G, Dietz A, Broglie MA, Herold-Mende CC, Dyckhoff G, Boscolo-Rizzo P, Ezić J, Marienfeld R, Möller P, Kraus JM, Völkel G, Kestler HA, Brunner C, Schuler PJ, Wigand MC, Theodoraki MN, Doescher J, Hoffmann TK, Pawlita M, Waterboer T, Butt J. Antibody responses to cancer antigens identify patients with a poor prognosis among HPV-positive and HPV-negative head and neck squamous cell carcinoma patients. Clin Cancer Res. 2019 Aug 23. pii: clincanres.1490.2019. doi: 10.1158/1078-0432.CCR-19-1490.

Yuan Z, VanderWielen BD, Giaimo BD, Pan L, Collins CE, Turkiewicz A, Hein K, Oswald F, Borggrefe T, Kovall RA. Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site. Cell Rep. 2019 Jan 22;26(4):845-854.e6. doi: 10.1016/j.celrep.2018.12.097.

Close V, Close W, Kugler SJ, Reichenzeller M, Yosifov DY, Bloehdorn J, Pan L, Tausch E, Westhoff MA, Döhner H, Stilgenbauer S, Oswald F*, Mertens D*. FBXW7 mutations reduce binding of NOTCH1, leading to cleaved NOTCH1 accumulation and target gene activation in CLL. Blood. 2019 Feb 21;133(8):830-839. doi: 10.1182/blood-2018-09-874529. Epub 2018 Dec 3. (*corresponding authors).

Perkhofer L, Schmitt A, Romero Carrasco MC, Ihle M, Hampp S, Ruess DA, Hessmann E, Russell R, Lechel A, Azoitei N, Lin Q, Liebau S, Hohwieler M, Bohnenberger H, Lesina M, Algül H, Gieldon L, Schröck E, Gaedcke J, Wagner M, Wiesmüller L, Sipos B, Seufferlein T, Reinhardt HC, Frappart PO, Kleger A. ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage. Cancer Res. 2017 Oct 15;77(20): 5576-5590. doi: 10.1158/0008-5472.CAN-17-0634. Epub 2017 Aug 8.

Schochter F, Werner K, Köstler C, Faul A, Tzschaschel M, Alberter B, Friedl TWP, Polzer BM, Janni W, Rack B, Wiesmüller L. 53BP1 Accumulation in Circulating Tumor Cells Identifies Chemotherapy Responsive Metastatic Breast Cancer Patients. Cancers (Basel). 2020 Apr 9;12(4): 930. doi: 10.3390/cancers12040930.

Svinarenko M, Katz SF, Tharehalli U, Mulaw MA, Maier HJ, Sunami Y, Fischer SK, Chen Y, Heurich S, Erkert L, Tannapfel A, Wirth T, Schirmbeck R, Seufferlein T, Lechel A. An IKK/NF-κB activation/p53 deletion sequence drives liver carcinogenesis and tumor differentiation. Cancers (Basel). 2019 Sep 21;11(10). pii: E1410. doi: 10.3390/cancers11101410.

Jäger D, Lechel A, Tharehalli U, Seeling C, Möller P, Barth TFE, Mellert K. U-CH17P, -M and -S, a new cell culture system for tumor diversity and progression in chordoma. Int J Cancer. 2018 Apr 1;142(7):1369-1378. doi: 10.1002/ijc.31161. Epub 2017 Nov.