Research: Systemic amyloidosis

Systemic amyloidosis is a group of protein misfolding diseases that is caused by the formation of amyloid fibrils and their deposition in multiple organs. We are currently working on systemic AA amyloidosis and AL amyloidosis that are associated with fibrils derived from serum amyloid A protein or immunoglobulin light chains.

Selected references:

Westermark GT, Fändrich M, Westermark P
AA Amyloidosis: Pathogenesis and Targeted Therapy.
Annu. Rev. Pathol. Mech. Dis. 2015, 10, 321-344

Gellermann GP Appel TR, Tannert A, Radestock A, Hortschansky  P, Schroeckh V, Leisner C Lütkepohl T, Shtrasburg S, Röcken C, Pras M, Linke RP, Diekmann S, Fändrich M
Raft lipids as common components of human extracellular amyloid fibrils.
Proc. Natl. Acad. Sci. U.S.A. 2005, 102, 6297-6302

Röcken C, Fändrich M, Stix B, Tannert A, Hortschansky P, Reinheckel T, Saftig P, Kähne T, Menard R, Ancsin JB, Bühling F
Cathepsin protease activity modulates amyloid load in extracerebral amyloidosis
Journal of Pathology, 2006, 210, 478-487