Publications Philipp
2019
Halder S, Torrecilla I, Burkhalter MD, Popović M, Fielden J, Vaz B, Oehler J, Pilger D, Lessel D, Wiseman K, Singh AN, Vendrell I, Fischer R, Philipp M, Ramadan K. (2019) SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication. Nat Commun. 2019;10(1):3142
Burkhalter MD, Sridhar A, Sampaio P, Jacinto R, Burczyk MS, Donow C, Angenendt M, Competence Network for Congenital Heart Defects Investigators, Hempel M, Walther P, Pennekamp P, Omran H, Lopes SS, Ware SM*, Philipp M* (2019) Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis. J Clin Invest. 2019;130:2841-2855. * co-corresponding
Maerz LD, Burkhalter MD, Schilpp C, Wittekindt OH, Frick M, Philipp M (2019) Pharmacological cholesterol depletion disturbs ciliogenesis and ciliary function in developing zebrafish. Commun Biol. 2:31. doi: 10.1038/s42003-018-0272-7
Maerz LD*, Casar Tena T*, Gerhards J, Donow C, Jeggo PA, Philipp M (2019) Analysis of cilia dysfunction phenotypes in zebrafish embryos depleted of origin recognition complex factors. Eur J Hum Genet. doi: 10.1038/s41431-019-0338-0. * equal contribution
Keil M, Meyer MT, Dannheisig DP, Maerz LD, Philipp M, Pfister AS (2019) Loss of Peter Pan protein is associated with cell cycle defects and apoptotic events. Biochim Biophys Acta Mol Cell Res. pii: S0167-4889(18)30377-X. doi: 10.1016/j.bbamcr.2019.01.010
2018
Casar Tena T, Maerz LD, Szafranski K, Groth M, Blätte TJ, Donow C, Matysik S, Walther P, Jeggo PA, Burkhalter MD, Philipp M. Resting cells rely on the DNA helicase component MCM2 to build cilia, Nucl Acids Res, accepted
Ogungbenro Y, Casar Tena T, Gaboriau D, Lalor P, Dockery P, Philipp M, and Morrison CG
Centrobin controls primary ciliogenesis in vertebrates. J Cell Biol, accepted
2017
Original publications
Hempel M*, Casar Tena T*, Diehl T, Burczyk MS, Strom TM, Kubisch C, Philipp M#, Lessel D#.
Compound heterozygous GATA5 mutations in a girl with hydrops fetalis, congenital heart defects and genital anomalies. Hum Genet. 2017 doi: 10.1007/s00439-017-1762-2. *co-first, # co-last author
2016
Original publication
Lessel D, Muhammad T, Casar Tena T, Moepps B, Burkhalter MD, Hitz MP, Toka O, Rentzsch A, Schubert S, Schalinski A, Bauer UMM, Kubisch C, Ware SM, Philipp M (2016) The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5, Scientific Reports, 6:33231
Avila AI, Illing A, Becker F, Maerz LD, Morita Y, Philipp M, Burkhalter MD (2016) Xpg limits the expansion of haematopoietic stem and progenitor cells after ionising radiation, Nucl. Acids Res., 44(13):6252-6261
Stiff T*, Casar Tena T*, O'Driscoll M¶, Jeggo PA¶, Philipp M¶ (2016) ATR promotes cilia signalling; links to developmental impacts, Hum. Mol. Genet., 25(8):1574-1587
*equal contribution, ¶ corresponding author
Book chapter
Casar Tena T and Philipp M (2015) Assessing Smoothened-mediated Hedgehog signaling in zebrafish, Methods in Cell Biology, Vol. 132, 147-64
2015
Original publication
Burczyk MS, Burkhalter MD, Blätte T, Matysik S, Caron MG, Barak LS, Philipp M (2015) Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2, Biochemistry, 54(3):765-775
Review
Casar Tena T, Burkhalter MD, Philipp M (2015) Left-right asymmetry in the light of TOR: An update on what we know so far. Biol. Cell, 107(9):306-318
2014
Original publications
Lessel D, Vaz B, Halder S, Lockhart PJ, Marinovic-Terzic I, Lopez-Mosqueda J, Philipp M, et al. (2014) Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features, Nat. Genet., 46(11):1239-1244
Philipp M*, Berger IM, Just S, Caron MG (2014) Overlapping and opposing functions of G protein-coupled receptor kinase 2 (GRK2) and GRK5 during heart development. J. Biol. Chem. 289(38):26119-30
* corresponding author
2013
Original publications
Burkhalter MD, Fralish GB, Premont RT, Caron MG and Philipp M (2013) Grk5l controls heart development by limiting mTOR signaling during symmetry breaking, Cell Reports, 4, 625-32
Book chapter
Philipp M, Evron T, Caron MG (2013) The role of arrestins in development "The Molecular Biology of Arrestins", Progress in Molecular Biology and Translational Science, 118, 225-42
2012
Original publications
Philipp M*, Niederkofler V*, Debrunner M, AltherT, Kunz Beat, Stoeckli ET (2012) RabGDI conrols axonal midline crossing by regulating Robo1 surface expression, Neural Dev., 7:36, *equal contribution
Schuff M*, Siegel D*, Philipp M, Bundschu K, Heymann N, Donow C, Knöchel W (2012) Danio rerio nanog promotes proliferation and inhibits differentiation in mouse ES cells, Stem Cells and Development, 21:1225-38, *equal contribution
Review
Pandur P, Sirbu IO, Kühl SJ, Philipp M, Kühl M (2012) Islet1 expressing cardiac progenitor cells: A comparison across species. Dev. Genes Evol. 223(1-2):117-129.
2011
Original publications
Evron T, Philipp M, Lu J, Meloni AR, Burkhalter M, Chen W and Caron MG (2011) Growth arrest specific 8 (Gas8) and GPCR kinase 2 (GRK2) cooperate in the control of smoothenend signaling, J Biol Chem, 286, 27676-86
Soderblom EJ, Philipp M, Thompson JW, Caron MG and Moseley MA (2011) A quantitative label-free phosphoproteomics strategy for mulitfaceted experimental designs, Anal. Chem., 83,3758-64
2001-09
2009
Original publications
Gilsbach R, Röser C, Beetz N, Brede M, Hadamek K, Haubold M, Leemhuis J, Philipp M, Schneider J, Urbanski M, Szabo B, Weinshenker D, Hein L (2009) Genetic dissection of α2-adrenoceptor functions in adrenergic versus non-adrenergic cells. Mol. Pharm. 75(5):1160-70.
Chen M*, Philipp M*, Wang J, Premont RT, Garrison TR, Caron MG, Lefkowitz RJ, Chen W (2009) Activation of Wnt receptor LRP6 via phosphorylation by G protein-coupled receptor kinases 5 and 6. J. Biol. Chem. 284(50):35040-48. * equal contribution
Reviews
Philipp M, Caron MG (2009) Hedgehog Signaling: Is Smo a G Protein-Coupled Receptor? Curr. Biol. 19(3):R125-7.
2008
Original publications
Philipp M*, Fralish GB*, Meloni AR, Chen W, MacInnes AW, Barak LS, Caron MG (2008) Smoothened signaling in vertebrates is facilitated by a G-protein coupled receptor kinase. Mol. Bio. Cell. 19(12):5478-89. * equal contribution
2007
Original publications
Muthig V, Gilsbach R, Haubold M, Philipp M, Ivacevic T, Gessler M, Hein L (2007) Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of α2B-adrenoceptor deficient mice. Circ Res. 101(7):682-91.
2006
Book chapter
Philipp M, Stoeckli ET (2006) Tissue specific RNA interference. In: Biotechnology and Genetic Engineering Reviews, Vol 22, Harding S, Intercept Ltd, Nottingham, UK
2004
Original publications
Fagerholm V, Philipp M, Hein L, Scheinin M (2004) [Ethyl-3H]RS-79948-197 α2-adrenoceptor autoradiography validation in α2-adrenoceptor knockout mice. Eur. J. Pharmacol. 497(3):301-309.
Reviews
Philipp M, Hein L (2004) Adrenergic receptor knockout mice: distinct functions of 9 receptor subtypes. Pharmacol. Ther. 101(1):65-74.
Brede M, Philipp M, Knaus A, Muthig V, Hein L (2004) α2-Adrenergic receptor subtypes – Novel functions uncovered in gene-targeted mouse models. Biol. Cell. 96:343-348.
Book chapter
Brede M, Philipp M, Hein L (2004) Measurement of function and regulation of adrenergic receptors. In: Practical methods in cardiovascular research, Dhein S, Springer-Verlag, Heidelberg
2003
Original publications
Brede M, Nagy G, Philipp M, Sorensen JB, Lohse MJ, Hein L (2003) Differential control of adrenal and sympathetic catecholamine release by α2-adrenoceptor subtypes. Mol. Endocrinol. 17 (8):1640-1646.
Trendelenburg AU, Philipp M, Meyer A, Klebroff W, Hein L, Starke K (2003) All three α2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn Schmiedebergs Arch. Pharmacol. 368(6):504-12.
Paris A, Philipp M, Tonner PH, Steinfaht M, Lohse M, Scholz J, Hein L (2003) Activation of α2B-adrenoceptors mediates the cardiovascular effects of etomidate. Anesthesiology. 99(4):889-895.
2002
Original publications
Philipp M, Brede ME, Hadamek K, Gessler M, Lohse MJ, Hein L. (2002) Placental α2-adrenoceptors control vascular development at the interface between mother and embryo. Nat Genet. 31(3): 311-5.
Review
Philipp M, Brede M, Hein L (2002) Physiological significance of α2-adrenergic receptor subtype diversity: one receptor is not enough. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283(2):R287-95.
2001
Original publication
Bunemann M, Bucheler MM, Philipp M, Lohse MJ, Hein L (2001) Activation and deactivation kinetics of α2A-adrenoceptors and α2C-adrenoceptors adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents. J. Biol. Chem. 276(50): 47512-7.