Publications Philipp

2019

Halder S, Torrecilla I, Burkhalter MD, Popović M, Fielden J, Vaz B, Oehler J, Pilger D, Lessel D, Wiseman K, Singh AN, Vendrell I, Fischer R, Philipp M, Ramadan K. (2019) SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication. Nat Commun. 2019;10(1):3142

Burkhalter MD, Sridhar A, Sampaio P, Jacinto R, Burczyk MS, Donow C, Angenendt M, Competence Network for Congenital Heart Defects Investigators, Hempel M, Walther P, Pennekamp P, Omran H, Lopes SS, Ware SM*, Philipp M* (2019) Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis. J Clin Invest. 2019;130:2841-2855. * co-corresponding    

Maerz LD, Burkhalter MD, Schilpp C, Wittekindt OH, Frick M, Philipp M (2019) Pharmacological cholesterol depletion disturbs ciliogenesis and ciliary function in developing zebrafish. Commun Biol. 2:31. doi: 10.1038/s42003-018-0272-7

Maerz LD*, Casar Tena T*, Gerhards J, Donow C, Jeggo PA, Philipp M (2019) Analysis of cilia dysfunction phenotypes in zebrafish embryos depleted of origin recognition complex factors. Eur J Hum Genet. doi: 10.1038/s41431-019-0338-0. * equal contribution

Keil M, Meyer MT, Dannheisig DP, Maerz LD, Philipp M, Pfister AS (2019) Loss of Peter Pan protein is associated with cell cycle defects and apoptotic events. Biochim Biophys Acta Mol Cell Res. pii: S0167-4889(18)30377-X. doi: 10.1016/j.bbamcr.2019.01.010

2018

Casar Tena T, Maerz LD, Szafranski K, Groth M, Blätte TJ, Donow C, Matysik S, Walther P, Jeggo PA, Burkhalter MD, Philipp M. Resting cells rely on the DNA helicase component MCM2 to build cilia, Nucl Acids Res, accepted

Ogungbenro Y, Casar Tena T, Gaboriau D, Lalor P, Dockery P, Philipp M, and Morrison CG
Centrobin controls primary ciliogenesis in vertebrates. J Cell Biol, accepted

2017

Original publications

Hempel M*, Casar Tena T*, Diehl T, Burczyk MS, Strom TM, Kubisch C, Philipp M#, Lessel D#.
Compound heterozygous GATA5 mutations in a girl with hydrops fetalis, congenital heart defects and genital anomalies. Hum Genet. 2017 doi: 10.1007/s00439-017-1762-2. *co-first, # co-last author

2016

Original publication

Lessel D, Muhammad T, Casar Tena T, Moepps B, Burkhalter MD, Hitz MP, Toka O, Rentzsch A, Schubert S, Schalinski A, Bauer UMM, Kubisch C, Ware SM, Philipp M (2016) The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5, Scientific Reports, 6:33231      

 Avila AI, Illing A, Becker F, Maerz LD, Morita Y, Philipp M, Burkhalter MD (2016) Xpg limits the expansion of haematopoietic stem and progenitor cells after ionising radiation, Nucl. Acids Res., 44(13):6252-6261

 Stiff T*, Casar Tena T*, O'Driscoll M, Jeggo PA, Philipp M (2016) ATR promotes cilia signalling; links to developmental impacts, Hum. Mol. Genet., 25(8):1574-1587

*equal contribution, corresponding author

 

Book chapter

Casar Tena T and Philipp M (2015) Assessing Smoothened-mediated Hedgehog signaling in zebrafish, Methods in Cell Biology, Vol. 132, 147-64

2015

Original publication

Burczyk MS, Burkhalter MD, Blätte T, Matysik S, Caron MG, Barak LS, Philipp M (2015) Phenotypic regulation of the sphingosine 1-phosphate receptor miles apart by G protein-coupled receptor kinase 2, Biochemistry, 54(3):765-775

 

Review

Casar Tena T, Burkhalter MD, Philipp M (2015) Left-right asymmetry in the light of TOR: An update on what we know so far. Biol. Cell, 107(9):306-318

2014

Original publications

Lessel D, Vaz B, Halder S, Lockhart PJ, Marinovic-Terzic I, Lopez-Mosqueda J, Philipp M, et al. (2014) Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features, Nat. Genet., 46(11):1239-1244

Philipp M*, Berger IM, Just S, Caron MG (2014) Overlapping and opposing functions of G protein-coupled receptor kinase 2 (GRK2) and GRK5 during heart development. J. Biol. Chem. 289(38):26119-30

* corresponding author

2013

Original publications

Burkhalter MD, Fralish GB, Premont RT, Caron MG and Philipp M (2013) Grk5l controls heart development by limiting mTOR signaling during symmetry breaking, Cell Reports, 4, 625-32

Book chapter

Philipp M, Evron T, Caron MG (2013) The role of arrestins in development "The Molecular Biology of Arrestins", Progress in Molecular Biology and Translational Science, 118, 225-42

2012

Original publications

Philipp M*, Niederkofler V*, Debrunner M, AltherT, Kunz Beat, Stoeckli ET (2012) RabGDI conrols axonal midline crossing by regulating Robo1 surface expression, Neural Dev., 7:36, *equal contribution

Schuff M*, Siegel D*, Philipp M, Bundschu K, Heymann N, Donow C, Knöchel W (2012) Danio rerio nanog promotes proliferation and inhibits differentiation in mouse ES cells, Stem Cells and Development, 21:1225-38, *equal contribution

 

Review

Pandur P, Sirbu IO, Kühl SJ, Philipp M, Kühl M (2012) Islet1 expressing cardiac progenitor cells: A comparison across species. Dev. Genes Evol. 223(1-2):117-129.

2011

Original publications

Evron T, Philipp M, Lu J, Meloni AR, Burkhalter M, Chen W and Caron MG (2011) Growth arrest specific 8 (Gas8) and GPCR kinase 2 (GRK2) cooperate in the control of smoothenend signaling, J Biol Chem, 286, 27676-86

Soderblom EJ, Philipp M, Thompson JW, Caron MG and Moseley MA (2011) A quantitative label-free phosphoproteomics strategy for mulitfaceted experimental designs, Anal. Chem., 83,3758-64

2001-09

2009

Original publications

Gilsbach R, Röser C, Beetz N, Brede M, Hadamek K, Haubold M, Leemhuis J, Philipp M, Schneider J, Urbanski M, Szabo B, Weinshenker D, Hein L (2009) Genetic dissection of α2-adrenoceptor functions in adrenergic versus non-adrenergic cells. Mol. Pharm. 75(5):1160-70.

Chen M*, Philipp M*, Wang J, Premont RT, Garrison TR, Caron MG, Lefkowitz RJ, Chen W (2009) Activation of Wnt receptor LRP6 via phosphorylation by G protein-coupled receptor kinases 5 and 6. J. Biol. Chem. 284(50):35040-48. * equal contribution

Reviews

Philipp M, Caron MG (2009) Hedgehog Signaling: Is Smo a G Protein-Coupled Receptor? Curr. Biol. 19(3):R125-7.

 

2008

Original publications

Philipp M*, Fralish GB*, Meloni AR, Chen W, MacInnes AW, Barak LS, Caron MG (2008)  Smoothened signaling in vertebrates is facilitated by a G-protein coupled receptor kinase. Mol. Bio. Cell. 19(12):5478-89.    * equal contribution

 

2007

Original publications

Muthig V, Gilsbach R, Haubold M, Philipp M, Ivacevic T, Gessler M, Hein L (2007) Upregulation of soluble vascular endothelial growth factor receptor 1 contributes to angiogenesis defects in the placenta of α2B-adrenoceptor deficient mice. Circ Res. 101(7):682-91.

 

2006

Book chapter

Philipp M, Stoeckli ET (2006) Tissue specific RNA interference. In: Biotechnology and Genetic Engineering Reviews, Vol 22, Harding S, Intercept Ltd, Nottingham, UK

 

2004

Original publications

Fagerholm V, Philipp M, Hein L, Scheinin M (2004) [Ethyl-3H]RS-79948-197 α2-adrenoceptor autoradiography validation in α2-adrenoceptor knockout mice. Eur. J. Pharmacol. 497(3):301-309.

 Reviews

Philipp M, Hein L (2004) Adrenergic receptor knockout mice: distinct functions of 9 receptor subtypes. Pharmacol. Ther. 101(1):65-74.

Brede M, Philipp M, Knaus A, Muthig V, Hein L (2004) α2-Adrenergic receptor subtypes – Novel functions uncovered in gene-targeted mouse models. Biol. Cell. 96:343-348.

 Book chapter

Brede M, Philipp M, Hein L (2004) Measurement of function and regulation of adrenergic receptors. In: Practical methods in cardiovascular research, Dhein S, Springer-Verlag, Heidelberg

 

2003

Original publications

Brede M, Nagy G, Philipp M, Sorensen JB, Lohse MJ, Hein L (2003) Differential control of adrenal and sympathetic catecholamine release by α2-adrenoceptor subtypes. Mol. Endocrinol. 17 (8):1640-1646.

Trendelenburg AU, Philipp M, Meyer A, Klebroff W, Hein L, Starke K (2003) All three α2-adrenoceptor types serve as autoreceptors in postganglionic sympathetic neurons. Naunyn Schmiedebergs Arch. Pharmacol. 368(6):504-12.

Paris A, Philipp M, Tonner PH, Steinfaht M, Lohse M, Scholz J, Hein L (2003) Activation of α2B-adrenoceptors mediates the cardiovascular effects of etomidate. Anesthesiology. 99(4):889-895.


2002

Original publications

Philipp M, Brede ME, Hadamek K, Gessler M, Lohse MJ, Hein L. (2002) Placental α2-adrenoceptors control vascular development at the interface between mother and embryo. Nat Genet. 31(3): 311-5.

Review

Philipp M, Brede M, Hein L (2002) Physiological significance of α2-adrenergic receptor subtype diversity: one receptor is not enough. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283(2):R287-95.

 

2001

Original publication

Bunemann M, Bucheler MM, Philipp M, Lohse MJ, Hein L (2001) Activation and deactivation kinetics of α2A-adrenoceptors and α2C-adrenoceptors adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents. J. Biol. Chem. 276(50): 47512-7.