Publications Kühl

2019

Guo Y, DornT, Kühl SJ, Linnemann A, Rothe M, Pfister AS, Vainio S, Laugwitz KL, Moretti A, Kühl M (2019) The wnt inhibitor Dkk1 is required for maintaining the normal cardiac differentiation programm in Xenopus laevis, Dev. Biol., in press

Groß A*, Kracher B*, Kraus JM, Kühlwein SD, Pfister AS, Wiese S, Luckert K, Pötz O, Joos T, Van Daele D, De Raedt L, Kühl M, Kestler HA (2019) Representing dynamic biological networks with multi-scale probabilistic models, Commun. Biol. 17:21 * equal contribution

Zawerton A, Yao B, Yeager JP, Pippucci T, Haseeb A, Smith JD, Wischmann L, Kühl SJ, Dean JCS, Pilz DT, Holder SE, McNeill A, Graziano C, Lefebvre V (2018) De novo SXO4 variants cause a neurodevelopmental disease associated with mild dysmorphism, Am. J. Hum. Genet., 104:246-59

2018

Original publications

Flach H, Krieg J, Hoffmeister M, Dietmann P, Reusch A, Wischmann L, Kernl B, Riegger R, Oess S, Kühl SJ (2018) Nosip functions during vertebrate eye and cranial cartilage development, Dev Dyn, 247:1070-82

Siegle L, Schwab JD, Kühlwein SD, Lausser L, Tümpel S, Pfister AS, Kühl M, Kestler HA (2018) A Bloolean network of the crosstalk between IGF and Wnt signaling in aging satellite cells, Plos One, 13:e0195126

Seigfried FA, Dietmann P, Kühl M, Kühl SJ (2018) Expression of the adhesion G protein-coupled receptor A2 (adgra2) during Xenopus laevis development, Gene Expr Patterns, 28:54-61

 

Reviews

Pfister AS, Kühl M (2018) Of Wnts and ribosomes. Prog Mol Biol Transl Sci, 153, 153:131-155

2017

Schwab JD, Siegle L, Kühlwein SD, Kühl M, Kestler HA (2018) Stability of signaling pathways during aging – A Boolean network approach, Biology, 18:6

Sträng JE, Schuler R, Kühl M*, Kestler HA* (2017) Switch-like behavior enables Wnt11 concentration specific response during dorso-ventral axis formation in Xenopus laevis. J. Theor. Biol. 429, 82-94, *corresponding authors

Hoffmeister M*, Krieg J*, Ehrke A, Seigfried FA, Wischmann L, Dietmann P, Kühl SJ, Oess S (2017) Developmental neurogenesis in mouse and Xenopus is impaired in the absence of Nosip, Dev. Biol., 429:200-212, * equal contribution

Seigfried FA, Cizelsky W, Pfister A, Dietmann P, Walther P, Kühl M, Kühl SJ (2017) Frizzled 3 acts upstream of Alcam during embryonic eye development, Dev. Biol., 426:69-83

Hempel A, Kühl SJ, Rothe M, Tata PR, Sirbu IO, Vainio SJ, Kühl M (2017) The CapZ interacting protein Rcsd1 is required for cardiogenesis downstream of Wnt11a in Xenopus laevis, Dev. Biol., 424:28-39

Kiem LM, Dietmann P, Linnemann A, Schmeisser MJ, Kühl SJ (2017) The Nedd4 binding protein 3 is required for anterior neural development in Xenopus laevis, Dev. Biol., 423:66-76

Rothe M, Kanwal N, Dietmann P, Seigfried FA, Hempel A, Schütz D, Reim D, Engels R, Linnemann A, Schmeisser MJ, Bockmann J, Kühl M, Boeckers TM, Kühl SJ (2017) An Epha4/Sipa1l3/Wnt pathway regulates eye development and lens maturation, Development, 144:321-33

2016

Original publications

Rothe M, Menteiro F, Dietmann P, Kühl SJ (2016) Comparative expression study of sipa family members during Xenopus laevis development, Dev. Genes Evo., 226:269-82

Oswald F, Rodriguez P, Giaimo BD, Antonello ZA, Mira L, Mittler G, Thiel VN, Collins KJ, Tabaja N, Cizelsky W, Rothe M, Kühl SJ, Kühl M, Ferrante F, Hein K, Kovall RA, Dominguez M, Borggrefe T (2016) A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes, Nucl. Acids Res., 44:4703-20

Hempel A, Pagnamenta AT, Blyth M, Mansour S, McConnell V, Kou I, Shiro I, Tsurusaki Y, Matsumoto N, L-Castro A, Plessi G, Albrecht B, Battaglia A, Taylor JC, Howard MF, Keays D, Sohal AS, Kühl SJ, Kini U, McNeill A (2015) Deletions and de novo mutations of SOX11 are associated with a neurodevelopmental disorder with features of Coffin-Siris syndrome, J. Med. Genet., 53:152-62

Dolnik A*, Kanwal N*, Mackert S*, Halbedl S, Proepper C, Bockmann J, Schoen M, Boeckers TM, Kühl SJ+, Schmeisser MJ+ (2015) Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3, J Neurochem, 136:28-35, *equal contribution +corresponding authors

Review

Hempel A, Kühl M (2016) A Matter of the Heart: The African Clawed frog Xenopus as a Model for Studying Vertebrate cardiogenesis and Congenital Heart Defects. J. Cardiovascular Development and Disease, 3, 21

Text books

Kühl S und Kühl M (2016) Die Abschlussarbeit in den Life Sciences, UTB, Ulmer Verlag

Öchsner W, Estner C, Kühl S (2016) Prüfungen erfolgreich bestehen in den Life Sciences, UTB, Ulmer Verlag, im Druck

2015

Original publications

Grieb M, Burkovski A, Straneg E, Kraus J, Gross A, Palm G, Kühl M*, Kestler HA* (2015) Prediction variabilities in cardiac gene expression with a Boolean network incorporatin uncertainly, PlosOne, e0131832, * corresponding authors

Hein K, Mittler G, Cizelsky W, Kühl M, Ferrante F, Liefke R, Berger I, Just S, Sträng JE, Kestler HA, Oswald F, Borggrefe T (2015) Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response, Sci Signal, 8, ra30

Pfister AS, Keil M, Kühl M (2015) The Wnt target protein Peter Pan defines a novel p53-independent nucleolar stress response pathway, J. Biol. Chem., in press

Tao S, Tang D, Morita Y, Sperka T, Omrani O, Lechel A, Sakk Vadim, Kraus J, Kestler H, Kühl M*, Rudolph KL* (2015) Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage, Embo J, 34, 624-640, * corresponding authors

Dorn T, Goedel A, Lam JT, Haas J, Tian Q, Herrmann F, Bundschu K, Dobreva G, Schiemann M, Dirschinger R, Guo Y, Kühl SJ, Sinnercher D, Lipp P, Laugwitz K, Kühl M+, Moretti A+ (2015) Direct Nkx2-5 transriptional repression of Isl1 controls cardiomyocyte subtype identity, Stem Cells, +corresponding authors, in press

Text books

Brockmann D und Kühl M (2015) Mit Erfolg promovieren in den Life Sciences, UTB, Ulmer Verlag

2014

Original publications

Hempel A and Kühl SJ (2014) Comparative expression analysis of cysteine-rich intestinal protein family members 1, 2 and 3 during Xenopus laevis embryogenesis, Int J Dev Biol, 58(10-12):841-9

Cizelsky W*, Tata A*, Kühl M+, Kühl SJ+ (2014) The Wnt/JNK target gene alcam is required for embryonic kidney development, Development, 141, 2064-74, *equal authors, +corresponding authors

Wehner D, Cizelsky W, Vasudevaro MD, Ozhan H, Haase C, Kagermeier-Schenk, Röder A, Dorsky RI, Moro E, Argenton F, Kühl M, Weidinger G (2014) Wnt/b-Catenin signaling defines organizing centers that orchestrate growth and differentiation of the regenerating zebrafish caudal fin, Cell Reports, 6, 467-81

Guo Y*, Kühl SJ*, Pfister AS, Cizelsky W, Denk S, Beer-Molz L, Kühl M (2014) Comparative analysis reveals distinct and overlapping functions of Mef2c and Mef2d during cardiogenesis in Xenopus leavis, Plos One, 9(1), e87294, *equal contribution

Book chapters

Kühl M, Kracher B, Groß A, Kestler HA (2014) Mathematical Models of Wnt signaling pathways, In: Hoppler S and Moon RT (eds), Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions. John Wiley & Sons, Ltd., Hoboken, New Jersey

Hoppler S, Mazotta S, Kühl M (2014) Wnt signaling in heart development, In: Hoppler S and Moon RT (eds), Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions. John Wiley & Sons, Ltd., Hoboken, New Jersey

Kühl S, Kühl M (2014) Introducing to b-catenin independent Wnt signaling pathwas, In: Hoppler S and Moon RT (eds), Wnt Signaling in Development and Disease: Molecular Mechanisms and Biological Functions. John Wiley & Sons, Ltd., Hoboken, New Jersey

Text book contribution

Kühl M (2014) Reifung, Altern und Tod, in: Pape HC, Kurtz A, Silbernagl S (eds) Physiologie, Thieme Verlag Stuttgart

2013

Original publications

Schmeisser JM, Kühl SJ, Schön M, Beth NH, Weis TM, Grabrucker AM, Kühl M, Böckers T (2013) The Nedd4 binding protein 3(N4BP3) is crucial for axonal and dendritic branching in developing neurons, Neural Dev, 8:18

Weidgang CE, Russel R, Tata PR, Kühl SJ, Illing A, Müller M, Lin Q, Brunner C, Böckers TM, Bauer K, Kartikasari AER, Guo Y, Radenz M, Bernemann C, Weiß M, Seufferlein T, Zinke M, Iacovino M, Kyba M, Schöler HR, Kühl M, Liebau S, Kleger A (2013) Tbx3 directs cell-fate decision towards mesendoderm, Stem Cell Reports, 1, 248-65

Özan G,Sezgin E, Wehner D, Pfister AS, Kühl SJ, Kagermeier-Schenk B, Kühl M, Schwille P and Weidinger G (2013) Lypd6 enhances Wnt/b-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains, Dev. Cell, 26, 331-45

Cizelsky W*, Hempel A*, Tao S, Metzig M, Hollemann T, Kühl M, Kühl SJ (2013) Sox4 and Sox11 function during Xenopus laevis eye development, Plos One,  8(7):e69372, * equal contribution

Reviews

Kühl SJ and Kühl M ( 2013) The role of Wnt/b-catenin signaling in stem cells, BBA general subjects, 1820, 2297-306

Pandur P, Sirbu IO, Kühl SJ, Philipp M, Kühl M (2013) Islet1 expressing cardiac progenitor cells: A comparison across species, Dev. Genes Evol., 223, 117-29

2012

Original publications

Herrmann F*, Groß A*, Zhou D, Kestler HA, Kühl M (2012) A boolean model of the cardiac regulatory network determining first and second heart field identity, Plos one, 7(10):e46768, *equal contribution

Murugan S, Shan J, Kühl SJ, Tata A, Pietulä I, Kühl M and Vainio SJ (2012) WT1 and Sox11 regulate synergistically the promotor of Wnt4 gene that encodes a critical signal for nephrogenesis, Exp. Cell Res., 318, 1134-45

Hopfensitz M, Müssel C, Wawra C, Maucher M, Kühl M, Neumann H, Kestler HA (2012) Multiscale binarization of gene expression data for reconstructing Boolean networks, IEEE Trans Comp Biol Bioinform, 9,487-98

Comments

Kühl S und Kühl M (2012) Nobelpreise 2012, Physiologie oder Medizin, Naturwissenschaftliche Rundschau, 12, 5-7

Text books

Kühl S und Kühl M (2012) Stammzellbiologie, UTB, Eugen Ulmer Verlag, Stuttgart

2011

Original publications

Herrmann F*, Bundschu K*, Kühl SJ, Kühl M (2011) Tbx5 overexpression favours a first heart field lineage in murine embryonic stem cells and in Xenopus laevis embryos, Dev. Dyn., 240, 2634-45, * both contributed equally

Tao S, Kühl M, Kühl SJ (2011) Expression of periostin during Xenopus laevis embryogenesis, Dev. Genes Evol., 221, 247-54

Tecza A, Bugner V, Kühl M, Kühl SJ (2011) Pes1 and ppan function during Xenopus laevis pronephros development, Biol. Cell, 103, 483-98, cover image

Bugner V, Aurhammer T and Kühl M (2011) Xenopus laevis insulin receptor substrate IRS-1 is important for eye development, Dev. Dyn., 240, 17-15

Guo Y, Christine KS, Conlon F, Gessert S, Kühl M (2011) Expression analysis of epb41l4a during Xenopus laevis embryogenesis, Dev. Genes Evol., 221, 118-9

Maucher M*, Kracher B*, Kühl M, Kestler H (2011) Inferring Boolean network structure via correlation, Bioinformatics, 27, 1529-36, * both contributed equally

Bugner V, Tecza A, Gessert S, Kühl M (2011) Peter Pan functions independent of its role in ribosome biogenesis during early eye and craniofacial cartilage development in Xenopus laevis, Development, 138, 2369-78

Gessert S, Schmeisser MJ, Tao S, Böckers TM, Kühl M (2011) The spatio-temporal expression of ProSAP/Shank family members and their interaction partner LAPSER1 during Xenopus laevis development, Dev. Dyn., 240, 1528-36

Tata RP, Tata NR, Kühl M, Sirbu IO (2011) Identification of a novel epigenetic regulatory region within the pluripotency associated microRNA cluster, EEmiRC, Nucleic Acids Res., 39, 3574-81

Reviews

Kühl SJ and Kühl M (2011) Improving cardiac function after injury: are we a step closer? BioEssays, 33, 669-73

Kestler HA and Kühl M (2011) Generating a Wnt switch: it´s all about the right dosage, J. Cell Biol., 193, 431-3

2010

Original publications

Gessert S, Bugner V, Tecza A, Pinker M, Kühl M (2010) FMR1/FXR1 and the miRNA pathway are required for eye and neural crest development, Dev. Biol., 341, 222-35

Reviews

Gessert S and Kühl M (2010) The multiple phases and faces of Wnt signaling during cardiac differentiation and development, Circ. Res., 107, 186-99

Rao TP and Kühl M (2010) An updated overview of Wnt signaling pathways: a prelude for more, Circ. Res., 106, 1798-806

Text book

Kühl M und Gessert S (2010) Entwicklungsbiologie, UTB Basics, Eugen Ulmer Verlag, Stuttgart

2009

Original publications

Gessert S and Kühl M (2009) Comparative gene expression analysis and fate mapping studies suggest an early segregation of cardiogenic lineages in Xenopus laevis, Dev. Biol. 334, 395-408

2008

Original publications

Gessert S, Maurus D, Brade T, Walther P, Pandur P, Kühl M (2008) DM-GRASP/ALCAM/CD166 is required for cardiac morphogenesis and maintenance of cardiac identity in first heart field derived cells, Dev. Biol. 321, 150-61

Gessert S, Maurus D, Kühl M (2008) Repulsive guidance molecule A (RGM A) and its receptor Neogenin during neural and neural crest development of Xenopus laevis, Biol. Cell, 100, 659-73, cover image

Reviews

Kestler HA, Wawra C, Kracher B, Kühl M (2008) Network modeling of signal transduction: establishing of a global view, BioEssays, 30, 1110-25

Kestler HA, Kühl M (2008) From individual Wnt pathways towards a Wnt signalling network, Phil. Trans. R. Soc. B, 363, 1333-47

Book chapters

Kühl M, Pandur P (2008) Dorsal axis duplication as a functional read-out for Wnt acitivity, Ed: Vincan E. Humana Press Inc., New Jersey, USA

Kühl M, Pandur P (2008) Measuring CamKII activity in Xenopus embryos as a read-out for non-canonical Wnt signaling, Ed: Vincan E. Humana Press Inc., New Jersey, USA

2007

Original publications

Anton R, Kestler HA, Kühl M (2007) β-catenin signalling contributes to stemness and regulates differentiation in murine embryonic stem cells, FEBS Letters 581, 5247-5254

Gessert S*, Maurus D*, Rössner A, Kühl M (2007) Pescadillo is required for Xenopus laevis eye and neural crest development, Dev. Biol. 310, 99-112, * both contributed equally

Brade T, Gessert S, Kühl M, Pandur P (2007) The amphibian second heart field: Xenopus islet-1 is required for cardiovascular development, Dev. Biol. 311, 297-310

Wawra C, Kühl M, Kestler HA (2007) Extended analyses of the Wnt/beta-catenin pathway: robustness and oscillatory behavior, FEBS Lett, 581, 4043-8

Giamas G, Shoshiashvili L, Hirner H, Grithey A, Gessert S, Kühl M, Henne-Bruns D, Vorgias CE, Knippschild U (2007) Phosphorylation of CKIδ by PKA, Akt, CLK2 and PKC: Identification of Ser370 as the major phosphorylation site targeted by PKA in vitro and in vivo, Biochem. J. 406, 389-398

Reviews

Anton R, Kühl M, Pandur P (2007) A molecular signature of the master heart cell, BioEssays, 29,422-26

2006

Original publications

Cus R, Maurus D, Kühl M (2006) Cloning and developmental expression of WSTF during Xenopus laevis embryogenesis, Gen Expr. Patt 6, 340-346

Reviews

Brade T, Männer J, Kühl M (2006) Wnt signaling during cardiac development and remodelling. Cardiovasc. Res., 72, 198-209

Quaiser T, Anton R, Kühl M (2006) Kinases and G proteins join the Wnt receptor complex. BioEssays, 128, 339-343

Book chapters

Kühl M, Moon RT (2006) How to assay non-canonical Wnt signaling: A critical analysis, in: Analysis of growth factor signaling in embryos, pp 29-35, Ed.: Whitman M, Sater AK. CRC press, Francis & Taylor, Boca Raton, FL, USA

2005

Original publications

Maurus D, Heligon C, Bürger-Schwärzler A, Brändli A, Kühl M (2005) Noncanonical Wnt-4 signaling and EAF2 are required for eye development in Xenopus laevis, EMBO J. 24, 1181-1181

Koyanagi M, Haendeler J, Badorff C, Brandes RP, Hoffmann J, Pandur P, Zeiher A, Kühl M, Dimmeler S (2005) Non-canonical Wnt signaling enhances differentiation of human circulating progenitor cells to cardiomyogenic cells, J. Biol. Chem. 290, 16838-16842

2004

Reviews

Maurus D, Kühl M (2004) Getting an embryo into shape. BioEssays, 26, 1272-1275

Kühl M (2004) The Wnt/calcium pathway: biochemical mediators, tools and future requirements. Front. Biosci. 9, 967-974

Text books

Linnemann M, Kühl M (2004) Biochemie für Mediziner, Springer Verlag Heidelberg, 7. Auflage (vorherige Auflagen: 2002, 1999, 1995, 1993, 1992, 1992)

2003

Original publications

Sheldahl LC, Slusarski D, Pandur P, Miller J, Kühl M, Moon RT (2003) Dishevelled activates Ca2+ flux, PKC and CamKII signaling in vertebrate embryos, J. Cell Biol. 161, 769-777

Book chapters

Kühl M, ” Entwicklung und Altern” (2003) in: Lehrbuch Vorklinik (GK1), Hrsg: Unsicker, Schmidt, Fachhrsg: Birnbaumer, Kurtz, Schartl, Unsicker, Deutscher Ärzteverlag, C 575- 596

Hollemann T, Chen Y, Sölter M, Kühl M, Pieler T (2003) Embryonic explants from Xenopus laevis as an assay system to study differentiation of multipotent precursor cells, in: Cell biology: A Laboratory handbook, 3rd Ed., Ed: J.E. Celis, Elsevier Science, San Diego, USA

Behrens J, Kühl M (2003) Wnt signal transduction pathways: An overview. In: Kühl M (Editor): Wnt signalling in development, Landes Bioscience, Georgetown (Texas, USA), pp 1-14

Pandur P, Kühl M (2003) Wnt signalling in heart development. In: Kühl M (Editor): Wnt signalling in development, Landes Bioscience, Georgetown (Texas, USA), pp 170-183

2002

Original publications

Schwarz-Romond T, Asbrand C, Bakkers J, Kühl M, Schaeffer HJ, Huelsken J, Behrens J, Hammerschmidt M, Birchmeier W (2002) The ankyrin repeat protein Diversin recruits Casein kinase l epsilon to the beta-catenin degradation complex and acts in both canonical Wnt and non-canonical Wnt/JNK signaling, Genes Dev. 15, 2073-84

Pandur P, Läsche M, Eisenberg L, Kühl M (2002) Wnt-11 stimulation of a non-canonical Wnt-pathway is required for cardiogenesis, Nature 418, 636-641

Hitz MP, Pandur P, Brand T, Kühl M (2002) Cardiac specific expression of Xenopus Popeye-1 (Pop-1). Mech. Dev. 115, 123-126

Martin B, Schneider R, Janetzky S, Waibler Z, Pandur P, Kühl M, Behrens J, von der Mark K, Starzinski-Powitz A, Wixler V (2002) The LIM-only protein FHL2 interacts with β-catenin and promotes differentiaion of mouse myoblasts. J. Cell Biol. 159, 113-122

Reviews

Kühl M (2002) Non-canonical Wnt signaling in Xenopus: regulation of axis formation and gastrulation. Sem. Cell Dev. Biol., 13, 243-249

Pandur P, Maurus D, Kühl M (2002) Increasingly complex: New players enter the Wnt signaling network. BioEssays 24, 881-885