Publikation January 2023
Christof M. Gebhardt and IRF4 International Consortium authors and contributions
A multimorphic mutation in IRF4 causes human autosomal dominant combined immunodeficiency
About us
At the Institute of Biophysics, we are looking at the dynamics and mechano-chemical function of individual molecules and their interactions and transport processes inside of living cells with the aim of increasing the mechanistic understanding of important biological processes including gene expression, DNA repair and chromatin organization.
For this task, we are developing novel methodologies in an interdisciplinary approach between Physics, Biology and Data Sciences, including single-molecule FRET, single-molecule microscopy in living cells, super-resolution optical microscopy and single-molecule force spectroscopy. In addition, we are developing data analysis methods to foster a quantitative understanding of biological processes.
Leitung/Director:
Prof. Dr. Jens Michaelis
Prof. Dr. Christof Gebhardt
News
January 2023
Congratulations on successfully defended doctoral thesis to Anja Reisser!
Publication November 2022
Anna Sefer, Eleni Kallis, Tobias Eilert, Carlheinz Röcker, Olga Kolesnikova, David Neuhaus, Sebastian Eustermann, Jens Michaelis
Structural dynamics of DNA strand break sensing by PARP-1 at a single-molecule level
October 2022
Congratulations on successfully defended doctoral thesis to Thomas Vomhof!
Publication October 2022
Maximilian Fellermann, Mia Stemmer, Reiner Noschka, Fanny Wondany, Stephan Fischer, Jens Michaelis, Steffen Stenger, Holger Barth
Clostridium botulinum C3 Toxin for Selective Delivery of Cargo into Dendritic Cells and Macrophages
Publication September 2022
Lisa Streit, Timo Kuhn, Thomas Vomhof, Christof M. Gebhardt und Jens Michaelis
Stress induced TDP-43 mobility loss independent of stress granules
July 2022
Congratulations on successfully defended doctoral thesis to Timo Kuhn!
July 2022
Congratulations on successfully defended doctoral thesis to Oliver Kuchler!
Publication June 2022
Christof M. Gebhardt
Quantum Optical Microphone in the Audio Band
Publication May 2022
Oliver Kuchler, Thomas Vomhof, Johannes Hettich, Christof M. Gebhardt and Jens Michaelis
Single-molecule tracking (SMT) and localization of SRF and MRTF transcription factors during neuronal stimulation and differentiation
May 2022
Congratulations on successfully defended doctoral thesis to Lisa Streit!
Publication March 2022
Andreas Große-Berkenbusch and Christof M. Gebhardt
Myosin VI regulates the spatial organisation of mammalian transcription initiation
February 2022
Congratulations on successfully defended doctoral thesis to Uwe Jantzen and Johannes Hettich!
Publication January 2022
Johannes Hettich and Christof M. Gebhardt
Periodic synchronization of isolated network elements facilitates simulating and inferring gene regulatory networks including stochastic molecular kinetics