Dr. Ion Cristian Cirstea
Adresse: Albert-Einstein-Allee 11, 89081 Ulm
E-Mail: Ion.Cirstea(at)uni-ulm.de
Fon: +497315036214
Fax: +497315036202
Mitarbeitende
Dr. rer. nat. Ion Cristian Cirstea
Research interest
RAS signaling pathways and biological processes dysregulated in RASopathies, cancer and (premature) aging.
Identification of novel RAS interactors and their underlying role in RAS function.
Functional characterization of novel RASopathy genes/mutations.
Non-canonical functions of RAS: energy metabolism, bone remodeling, cardiac dysfunction and SARS-CoV-2 infection.
Academic and Scientific Education
| 2023 | Group Leader, Institute of Applied Physiology, Ulm University |
| 2016-2023 | Group Leader, Institute of Comparative Molecular Endocrinology, Ulm University |
| 2012-2016 | Independent Research Fellow, Leibniz Institute on Aging, Jena |
| 2007-2012 | Postdoc, Institute of Biochemistry and Molecular Biology II, Heinrich-Heine-University Hospital, Düsseldorf |
| 2003-2007 | PhD, Max Planck Institute of Molecular Physiology (Dortmund, Germany) |
| 2001-2003 | Master, Biochemistry and Molecular Biology, University of Bucharest |
| 1996-2000 | Diploma, Biochemistry and Molecular Biology, University of Buchares |
Selected publications
Motta M*, Fidan M*, Bellacchio E, Pantaleoni F, Schneider-Heieck K, Coppola S, Borck G, Salviati L, Zenker M, Cirstea IC**, Tartaglia M**. Dominant Noonan syndrome-causing LZTR1 mutations specifically affect the Kelch domain substrate-recognition surface and enhance RAS-MAPK signaling. Hum. Mol. Genet. 28(6), 1007–1022 (2019). *, equal contribution; **, equal contribution and joint coordination
Cirstea IC, Gremer L, Dvorsky R, Zenker M, Ahmadian MR. Diverging gain-of-function mechanisms of two novel KRAS mutations associated with Noonan and Cardio-Facio-Cutaneous syndromes. Hum. Mol. Genet. 2013 Jan 15; 22(2):262-70.
Cirstea IC, Kutsche K, Dvorsky R, Gremer L, Carta C, Horn D, Roberts AE, Lepri F, Merbitz-Zahradnik T, König R, Kratz CP, Pantaleoni F, Dentici ML, Joshi VA, Kucherlapati RS, Mazzanti L, Mundlos S, Patton MA, Silengo MC, Rossi C, Zampino G, Digilio C, Stuppia L, Seemanova E, Pennacchio LA, Gelb BD, Dallapiccola B, Wittinghofer A, Ahmadian MR, Tartaglia M, Zenker M. A restricted spectrum of NRAS mutations causes Noonan syndrome. Nat. Genet. 2010 Jan;42(1):27-9.