Research interests

  • Disease ecology
  • Host-pathogen interactions
  • Plant-pollinator networks
  • Virome and Microbiome





Scientific projects

I am an evolutionary ecologist studying host-pathogen interactions and the dynamics and evolution of diseases, using primarily insect models. I combine field work, experimental infections and large sequencing analyses in my research.

My current projects are (i) the effect of ecological, evolutionary and genetic drivers on disease transmission; (ii) the study of viral diversity in insect pollinators and (iii) the evolution of insect immunity (DFG funded project within the priority program GEvol “Genomic Basis of Evolutionary Innovations”: ImmuNov).

See also my website for more details on my work:, or follow me on Twitter: @VBSDoublet.



Doublet V, Oddie MAY, Mondet F, Forsgren E, Dahle B, Furuseth-Hansen E, Williams GR, De Smet L, Natsopoulou ME, Murray TE, Semberg E, Yañez O, de Graaf DC, Le Conte Y, Neumann P, Rimstad E, Paxton RJ, de Miranda JR (2024). Shift in virus composition in honeybees (Apis mellifera) following worldwide invasion by the parasitic mite and virus vector Varroa destructorRoyal Society Open Science, 11: 231529. (


Kutzer M, Gupta V, Neophytou K, Doublet V, Monteith KM, Vale PF (2023). Intraspecific genetic variation in host vigour, viral load, and disease tolerance during Drosophila C Virus infection. Open Biology, 13: 230025. (

Manley R, Doublet V, Wright ON, Doyle T, Refoy I, Hedges S, Pascall D, Carvell C, Brown MJF, Wilfert L (2023). Conservation measures or hotspots of disease transmission? Agri-environment schemes can reduce disease prevalence in pollinator communities. Philosophical Transactions of the Royal Society B, 378: 20220004. (


Doublet V, Doyle T, Refoy I, Hedges S, Carvell C, Brown MJF, Wilfert L (2022). Increasing flower species richness in agricultural landscapes alters insect pollinator networks: implications for bee health and competition. Ecology and Evolution, 12(10): e9442. (

Kutzer M, Gupta V, Neophytou K, Doublet V, Monteith KM, Vale PF (2022). The restriction factor pastrel is associated with host vigor, viral titer, and variation in disease tolerance during Drosophila C Virus infection. bioRxiv, (

de Miranda JR, Brettell LE, Chejanovsky N, Childers AK, Dalmon A, Deboutte W, de Graaf DC, Doublet V, Gebremedhn H, Genersch E, Gisder S, Granberg F, Haddad NZ, Kaden R, Manley R, Matthijnssens J, Meeus I, Migdadi H, Milbrath MO, Mondet F, Remnant EJ, Roberts JMK, Ryabov EV, Sela N, Smagghe G, Somanathan H, Wilfert L, Wright ON, Martin SJ, Ball BV (2022). Cold case: The disappearance of Egypt bee virus, a fourth distinct master strain of deformed wing virus linked to honeybee mortality in 1970’s Egypt. Virology Journal, 19:12. (


Archer CR, Fähnle J, Pretzner M, Üstüner C, Weber N, Sutter A, Doublet V, Wilfert L (2021). Complex relationship between amino acids, fitness and food intake in Bombus terrestris. Amino Acids, 53: 1545-1558. (


Wilfert L, Brown MJF, Doublet V (2020). OneHealth implications of infectious diseases of wild and managed bees. Journal of Invertebrate Pathology, 186: 107506. (

Beaurepaire A, Piot N, Doublet V, Antunez K, Campbell E, Chantawannakul P, Chejanovsky N, Gajda A, Heerman M, Panziera D, Smagghe G, Yanez O, de Miranda JR, Dalmon A (2020). Diversity and global distribution of viruses of the western honey bee, Apis mellifera. Insects, 11: 239. (


Tehel A, Vu Q, Bigot D, Gogol-Döring A, Koch P, Jenkins C, Doublet V, Theodorou P, Paxton R (2019). The two prevalent genotypes of an emerging infectious disease, Deformed wing virus, cause equally low pupal mortality and equally high wing deformities in host honey bees. Viruses, 11: 114. (


Natsopoulou ME, McMahon DP, Doublet V, Frey E, Rosenkranz P, Paxton RJ (2017). The virulent, emerging genotype B of Deformed wing virus is closely linked to overwinter honeybee worker loss. Scientific Reports, 7: 5242. (

Doublet V*, Poeschl Y*, Gogo-Döring A, Alaux C, Annoscia D, Aurori C, Barribeau SM, Bedoya-Reina OC, Brown MJF, Bull JC, Flenniken ML, Galbraith DA, Genersch E, Gisder S, Grosse I, Holt HL, Hultmark D, Lattorff HMG, Le Conte Y, Manfredini F, McMahon DP, Moritz RFA, Nazzi F, Nino EL, Nowick K, van Rij RP, Paxton RJ, Grozinger CM (2017). Unity in defence: honeybee workers exhibit conserved molecular responses to diverse pathogens. BMC Genomics, 18: 207. *Equal contributors. (


Doublet V, Paxton RJ, McDonnell C, Dubois E, Nidelet S, Moritz RFA, Alaux C, Le Conte Y (2016). Brain transcriptomes of honey bees (Apis mellifera) experimentally infected by two pathogens: Black queen cell virus and Nosema ceranae. Genomics Data, 10: 79-82. (

McMahon DP, Natsopoulou ME, Doublet V, Fürst M, Weging S, Brown MJF, Gogol-Döring A, Paxton RJ (2016). Elevated virulence of an emerging viral genotype as a driver of honeybee loss. Proceedings of the Royal Society B, 283: 20160811. (

Engel P, Kwong WK, McFrederick Q, Anderson KE, Barribeau SM, Chandler JA, Cornman RS, Dainat J, de Miranda JR, Doublet V, Emery O, Evans JD, Farinelli L, Flenniken ML, Granberg F, Grassis JA, Gauthier L, Hayer J, Koch H, Kocher S, Martinson V, Moran N, Munoz-Torres M, Newton I, Paxton RJ, Powell E, Sadd B, Schmid-Hempel P, Schmid-Hempel R, Song SJ, Schwarz RS, vanEngelsdorp D, Dainat B (2016). The bee microbiome: impact on bee health and model for evolution and ecology of host-microbe interactions. mBio, 7(2): e02164-15. (

Natsopoulou ME, Doublet V, Paxton RJ (2016). European isolates of the Microsporidia Nosema apis and Nosema ceranae have similar virulence in laboratory tests on European worker honey bees. Apidologie, 47(1): 57-65. (


Doublet V, Natsopoulou ME, Zschieche L, Paxton RJ (2015). Within-host competition among the honey bees pathogens Nosema ceranae and Deformed wing virus is asymmetric and to the disadvantage of the virus. Journal of Invertebrate Pathology, 124: 31-34. (

Natsopoulou ME, McMahon DP, Doublet V, Bryden J, Paxton RJ (2015). Interspecific competition in honeybee intracellular gut parasites is asymmetric and favours the spread of an emerging infectious disease. Proceedings of the Royal Society B, 282: 20141896. (

Doublet V, Labarussias M, de Miranda JR, Moritz RFA, Paxton RJ (2015). Bees under stress: sublethal doses of a neonicotinoid pesticide and pathogens interact to elevate honey bee mortality across the life cycle. Environmental Microbiology, 17(4): 969-983. (

Doublet V, Ubrig E, Alioua A, Bouchon D, Marcadé I, Maréchal-Drouard L (2015). Large gene overlaps and tRNA processing in the compact mitochondrial genome of the crustacean Armadillidium vulgare. RNA Biology, 12(10): 1159-1168. (


Huang SK, Csáki T, Doublet V, Dussaubat C, Evans JD, Gajda AM, Gregorc A, Hamilton MC, Kamler M, Lecocq A, Muz MN, Neumann P, Özkirim A, Schiesser A, Sohr AR, Tanner G, Tozkar CÖ, Williams GR, Wu L, Zheng H, Chen YP (2014). Evaluation of cage designs and feeding regimes for honey bee (Hymenoptera: Apidae) laboratory experiments. Journal of Economic Entomology, 107(1): 54-62. (


Suraporn S, Natsopoulou ME, Doublet V, McMahon DP, Paxton RJ (2013). Nosema ceranae is not detected in honey bees (Apis spp.) of northeast Thailand. Journal of Apicultural Research, 52(5): 259-261. (

Doublet V, Helleu Q, Raimond R, Souty-Grosset C, Marcadé I (2013). Inverted repeats and genome architecture conversions of terrestrial isopods mitochondrial DNA. Journal of Molecular Evolution, 77(3): 107-118. (

Fries I, Chauzat M-P, Chen YP, Doublet V, Genersch E, Gisder S, Higes M, McMahon DP, Martín-Hernández R, Natsopoulou ME, Paxton RJ, Tanner G, Webster TC, Williams GR (2013) Standard methods for Nosema research. In V Dietemann, JD Ellis, P Neumann (Eds). The COLOSS BEEBOOK: Volume II: Standard methods for Apis mellifera pest and pathogen research. Journal of Apicultural Research, 52(1). (

Williams GR, Alaux C, Costa C, Csáki T, Doublet V, Eisenhardt D, Fries I, Kuhn R, McMahon DP, Medrzycki P, Murray TE, Natsopoulou ME, Neumann P, Oliver R, Paxton RJ, Pernal SF, Shutler D, Tanner G, Van der Steen JJM, Brodschneider R (2013). Standard methods for maintaining adult Apis mellifera in cages under in vitro laboratory conditions. In V Dietemann; JD Ellis; P Neumann (Eds) The COLOSS BEEBOOK, Volume I: standard methods for Apis mellifera research. Journal of Apicultural Research, 52(1). (


Cordaux R, Pichon S, Ben Afia Hatira H, Doublet V, Grève P, Marcadé I, Braquart-Varnier C, Souty-Grosset C, Charfi-Cheikhrouha F, Bouchon D (2012). Widespread Wolbachia infection in terrestrial isopods and other crustaceans. Zookeys, 176: 123-131. (

Doublet V, Raimond R, Grandjean F, Lafitte A, Souty-Grosset C, Marcadé I (2012). Widespread atypical mtDNA structrure in isopods (Crustacea: Peracarida) related to a constitutive heteroplasmy in terrestrial species. Genome, 55(3): 234-244. (


Doublet V, Souty-Grosset C, Bouchon D, Cordaux R, Marcadé I (2008). A thirty million year-old inherited heteroplasmy. PLoS One, 3(8): e2938. (

Rispe C, Kutsukake M, Doublet V, Hudaverdian S, Legeai F, Simon J-C, Tagu D, Fukatsu T (2008). Large gene family expansion and variable selective pressures for cathepsin B in aphids. Molecular Biology and Evolution, 25(1): 5-17. (


Marcadé I, Cordaux R, Doublet V, Debenest C, Bouchon D, Raimond R (2007). Structure and evolution of the atypical mitochondrial genome of Armadillidium vulgare (Isopoda, Crustacea). Journal of Molecular Evolution, 65(6): 651-659. (


  • Dr. Vincent Doublet
  • Institute of Evolutionary Ecology
    and Conservation Genomics
    University of Ulm
    Albert-Einstein-Allee 11
    89081 Ulm