Gilbert Weidinger lab
The Weidinger lab studies the cellular and molecular mechanisms regulating regeneration of the fin and heart in zebrafish. We aim to identify the importance of cellular plasticity, in particular cellular dedifferentiation, for regenerative growth of these adult organs. Furthermore, we study the molecular mechanisms regulating cellular plasticity, tissue growth and patterning. Currently, we focus on the roles of signaling pathways, in particular Wnt signaling, and on the functions of transcription factors. To facilitate our studies of adult regeneration, we also develop novel transgenic tools and injury models. Our interest in Wnt signaling pathways extends beyond their role in regeneration; we study mechanisms of Wnt signaling regulation also in zebrafish embryos and ex vivo systems.
Overall our goal is to shed light on the mechanisms underlying the fascinating process of naturally occurring adult organ regeneration. A better understanding of these mechanisms will hopefully aid in the development of regenerative therapies in humans.