Completed Theses

2018

2016

• Sample Size Reassessment in Equivalence Trials with Binary Data**
• A Causal Analysis of Ventilator-Associated Pneumonia in Intensive Care / Bernd-Streitberg Award

2015

• Time-dependent Covariates in the Proportional Subdistribution Hazards Modell
• Zur Varianzschätzung des Mantel-Haenszel-Schätzers des Odds Ratios in stratifizierten Studien

2014

• Incidence rates and competing risks in the history of hospital epidemiology
• Nichtparametrische Schätzung einer Übergangswahrscheinlichkeit in einem Nicht-Markov illness-death-Modell mit Hilfe von konkurrierenden Risiken
• Comparison of Different Estimators regarding the Intra-Individual Correlation in Phase I Trials and their Usage for Trial Design**

2013

• The predicitive distribution of the residual variability in the linear model for clinical cross-over rials**, Bernd Streitberg Award
• Interaktion von Membranpermeabilität und zugrunde liegendem Mortalitätsrisiko bei inzidenten Dialyse Patienten der MPO Studie*

Cooperations with

Academic Partners*    Industry Partners**    International Cooperations***

2018

• Joint Models, Landmarking and the Ulm Osteoarthritis Study*
  

2017

• Multistate Modeling of Clinical Hold in Randomized Clinical Trials**. Student Award 2017 of the German Association for Medical Informatics, Biometry and Epidemiology.
  
• An Application of BLRM with Covariates for Dose Finding **. Young Statisticians Session 2018.
• Modeling time-dependent effects for competing risks endpoints in allogeneic stem cell transplantation - a piecewise constant approach* 

2016

• Nested Case-Control Designs and Exposure Density Sampling
• Joint Modelling of Overall Survival and Progression-free Survival**/***. Bernd Streitberg Award.
  
• Joint modelling of left-truncated observational studies: unmeasured 
  baseline covariates as a consequence of delayed study entry / Bernd Streitberg Award
• Pseudo-Value Regression for the Excess Length-of-Stay and subsequent Quality-of-Life associated with hospital-acquired Infections

2015

• Bayesian decision criteria in clinical development **
• Estimation of pregnancy outcome probabilities in the presence of heavy left-truncation. "Young Statisticians Session 2015"
• Nelson-Aalen and Aalen-Johansen estimators for randomly left-truncated and right-censored non-Markov multistate models with application to hospital epidemiology. Student Award 2015 of the German Association for Medical Informatics, Biometry and Epidemiology
• Analysis of time-dynamic oncological data - in the presence of a non-occurring event of interest */***
• Schätzung altersbedingter Herzkreislaufrisiken basierend auf Routinedaten*
• Evaluation of the impact of a clinical hold in survival studies under different assumptions regarding the true effect**
• Handling missing data using longitudinal or time-to-event techniques - Simulation studies and practical implementation in the Ulm Birth Cohort Study (UBCS)*
• Bayesian Phase II Optimization for Time-To-Event Data Based on Historical Information**
• Nonparametric estimation of cumulative incidence functions in the 
  presence of dependent left-truncation with application to pregnancy 
  outcome data

2014

• Planning of clinical survival studies in the presence of competing risks
• Wild bootstrapping Nelson-Aalen estimates with application in health services research* Bernd Streitberg Award
• Sample size calculations for overall survival in oncology trials incorporating a biomarker using multistate models**
• Investigating the performance of EWOC designs compared to 3+3 in early oncology trials based on historical data**
• Confidence intervals for the difference of proportions adjusted for covariates**
• Robustification of state space models*/***

Cooperations with

Academic Partners*    Industry Partners**    International Cooperations***