Completed Theses

Bachelor of Science

2020

  • Direct modeling of tumor growth and time to event data**/ Young Statisticians Session 2020
  • Operating Characteristics of Surrogate Endpoint Methods for Normally Distributed Data**/ Young Statisticians Session 2020
  • Bayesian Continued Process Verification for Biopharmaceuticals**
  • Multiple imputation under not-at-random missingness with application in prediction with qPCR data*

2019

  • Qualitätsauswertung der Krankenhausversorgung mit Hilfe von Martingal-Methoden für konkurrierende Risiken*
  • Circular statistics in a study connecting dentofacial data and wind instrument positioning*
  • Modeling of Dose-Exposure Relationships and Model-Based Extrapolation During Early Clinical Development**

2018

2016

  • Sample Size Reassessment in Equivalence Trials with Binary Data**
  • A Causal Analysis of Ventilator-Associated Pneumonia in Intensive Care/ Bernd-Streitberg Award

2015

  • Time-dependent Covariates in the Proportional Subdistribution Hazards Modell
  • Zur Varianzschätzung des Mantel-Haenszel-Schätzers des Odds Ratios in stratifizierten Studien

2014

  • Incidence rates and competing risks in the history of hospital epidemiology
  • Nichtparametrische Schätzung einer Übergangswahrscheinlichkeit in einem Nicht-Markov illness-death-Modell mit Hilfe von konkurrierenden Risiken
  • Comparison of Different Estimators regarding the Intra-Individual Correlation in Phase I Trials and their Usage for Trial Design**

2013

  • The predicitive distribution of the residual variability in the linear model for clinical cross-over rials**/ Bernd Streitberg Award
  • Interaktion von Membranpermeabilität und zugrunde liegendem Mortalitätsrisiko bei inzidenten Dialyse Patienten der MPO Studie*

Cooperations with

Academic Partners*    Industry Partners**    International Cooperations***

Master of Science

2020

  • Zusammenhang von Schmerz und Funktionalität im prä- und postoperativen Verlauf bei Patienten mit Osteoarthrose und deren Bedeutung für die Sterblichkeit*
  • General Independent Censoring in Event-Driven Trials with Staggered Entry*
  • Absolute risk prediction for nested exposure case-control sampling
  • Landmarking for left-truncated competing risk data with applications to pregnancy outcome registries*/ Young Statisticians Session 2020

2019

2018

  • Evaluating potential post-treatment preditive and prognostic markers with time-to-event data**
  • The statistical analysis if the DEcompressive surgery Plus hypoTHermia for Space Occupying Stroke (DEPTH-SOS) trial, with a view towards mortality and safety*
  • Joint Models, Landmarking and the Ulm Osteoarthritis Study*

2017

2016

  • Nested Case-Control Designs and Exposure Density Sampling
  • Joint Modelling of Overall Survival and Progression-free Survival**/*** Bernd Streitberg Award.
  • Joint modelling of left-truncated observational studies: unmeasured 
    baseline covariates as a consequence of delayed study entry/ 
    Bernd Streitberg Award
  • Pseudo-Value Regression for the Excess Length-of-Stay and subsequent Quality-of-Life associated with hospital-acquired Infections

2015

  • Bayesian decision criteria in clinical development**
  • Estimation of pregnancy outcome probabilities in the presence of heavy left-truncation/ "Young Statisticians Session 2015"
  • Nelson-Aalen and Aalen-Johansen estimators for randomly left-truncated and right-censored non-Markov multistate models with application to hospital epidemiology/ Student Award 2015 of the German Association for Medical Informatics, Biometry and Epidemiology
  • Analysis of time-dynamic oncological data - in the presence of a non-occurring event of interest*/***
  • Schätzung altersbedingter Herzkreislaufrisiken basierend auf Routinedaten*
  • Evaluation of the impact of a clinical hold in survival studies under different assumptions regarding the true effect**
  • Handling missing data using longitudinal or time-to-event techniques - Simulation studies and practical implementation in the Ulm Birth Cohort Study (UBCS)*
  • Bayesian Phase II Optimization for Time-To-Event Data Based on Historical Information**
  • Nonparametric estimation of cumulative incidence functions in the presence of dependent left-truncation with application to pregnancy outcome data

2014

  • Planning of clinical survival studies in the presence of competing risks
  • Wild bootstrapping Nelson-Aalen estimates with application in health services research*/ Bernd Streitberg Award
  • Sample size calculations for overall survival in oncology trials incorporating a biomarker using multistate models**
  • Investigating the performance of EWOC designs compared to 3+3 in early oncology trials based on historical data**
  • Confidence intervals for the difference of proportions adjusted for covariates**
  • Robustification of state space models*/***

Cooperations with

Academic Partners*    Industry Partners**    International Cooperations***

PhD

2018

  • Statistical Evaluation of Non-Standard Time-to-Event Outcomes in Biomedical Research: cumulative PhD where one paper has received the Gustav-Adolf-Lienert-Award