A : Originalarbeiten


(248) Stirmlinger N., Delling JP, Pfänder St, Boeckers TM Elevation of SHANK3 levels by antisense oligonucleotides directed against the 3`-UTR of the human SHANK3 mRNA. Nucleic Acid Therapeutics (2023) IF (5,4)

(249) Megat S, Mora N, Sanogo J, Catanese A, Ouali Alami N, Freischmidt A, Mingaj X, De Calbiac H, Muratet F, Dirrig-Grosch S, Dieterle St, Van Bakel N, Muller K, Sieverding K, Weishaupt J, Munch Andersen P, Weber M, Neuwirth Ch, Margelisch M, Sommacal A, Van Eijk K, Veldink JH, Project Mine Als Sequencing Consortium, Lautrette G, Couratier P, Boeckers T, Ludolph AC, Roselli F, Yilmazer-Hanke D, Millecamps St, Kabashi E, Storkebaum E, Sellier Ch, Dupuis L Loss of nucleoporin Nup50 is a risk factor for amyotrophic lateral sclerosis. Nature Com 20;14(1):342. doi: 10.1038/s41467-022-35724-1 (2023) IF (17,1)

(250) Li S, olde Heuvel F, Rehman R, Aousji O, Froehlich A, Li Z, Jark R, Zhang W, Conquest A, Woelfle S, Schoen M, O´Meara C, Reinhardt RL, Voehringer D, Kassubek J, Ludolph A, Huber-Lang M, Knöll B, Morganti-Kossmann MC, Brockmann MM, Boeckers TM, Roselli F Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection. Nature Com 13;14(1):200. doi: 10.1038/s41467-023-35806-8. (2023) IF (17,1)

(251) Bauer HF, Delling JP, Bockmann J, Boeckers TM, Schön M Development of sex- and genotype-specific behavioral phenotypes in a Shank3 ASD mouse model: A longitudinal view Front in Behavioural Neuroscience 9;16:1051175. doi: 10.3389/fnbeh.2022.1051175 (2023) IF (3,6)
(252) Atanasova E, Pérez Arévalo A, Graf I, Zhang R, Bockmann J, Lutz A, Boeckers TM Immune activation during pregnancy exacerbates ASD related alterations in Shank3-deficient mice. Mol Autism (2023) Jan 5;14(1):1. doi: 10.1186/s13229-022-00532-3. IF (6,5)
(253) Catanese A, Rajkumar S, Sommer D, Masrori P, Hersmus N, Van Damme P, Witzel S, Ludolph A, Ho R, Boeckers TM, Mulaw M Multi-omics and deep machine-learning approaches identify novel transcriptional and mutational signatures in amyotrophic lateral sclerosis. Brain Mar 8:awad075. doi: 10.1093/brain/awad075 (2023) IF (15,2)
(254) Woelfle S; Deshpande D; Feldengut S; Roselli F; Deisseroth K; Michaelis J; Boeckers TM; Schön M. CLARITY increases sensitivity and specificity of fluorescence immunostaining in long-term archived human brain tissue. BMC Biology 24;21(1):113. doi: 10.1186/s12915-023-01582-6. PMID: 37221592; PMCID: PMC10207789. (2023) IF (7,4)
(255) Ferhat A-T, Biton A, Verpy E, Forget B, de Chaumont F, Mueller F, Le Sourd A, Coqueran S, Schmitt J, Rochefort Ch, Rondi-Reig L, Leboucher A, Boland A, Fin B, Deleuze JF, Boeckers TM., Ey E, Bourgeron Th Excessive self-grooming of Shank3 mutant mice is associated with gene dysregulation and imbalance between the striosome and matrix compartments in the striatum. Frontiers in Molecular Neuroscience doi: 10.3389/fnmol.2023.1139118. eCollection (2023) IF (6,2)
(256) olde Heuvel F, Ouali Alami N, Aousji O, Wilhelm H, Deshpande D, Khatamsaz E, Catanese A, Woelfle S, Schön M, Jain S, Grabrucker St, Ludolph AC, Verpelli C, Michaelis J, Boeckers TM*, Roselli F* (*contributed equally) Shank2 identifies a subset of glycinergic neurons involved in altered nociception in an autism model. Mol Autism 14;14(1):21. doi: 10.1186/s13229-023-00552-7. (2023) IF (6,5)
(257) Ahmad M, Stirmlinger N, Stifel U, Lee S, Weingandt M, Kelp U, Bockmann J, Ignatius A, Boeckers TM, Tuckermann J Downregulation of the autism spectrum disorder gene Shank2 decreases osteoblast differentiation and bone mass. JBMR plus Dec 15;7(2):e10711. doi: 10.1002/jbm4.10711. PMID: 36751416; PMCID: PMC9893268. (2022) IF (3,8)

(258) Lan XY, Gu YY, Li MJ, Song TJ, Zhai FJ, Zhang Y, Zhan JS, Böckers TM, Yue XN, Wang JN, Yuan S, Jin M, Xie YF, Dang WW, Hong HH, Guo ZR, Wang XW, Zhang R Poly(I:C)-induced Maternal ImmuneActivation Causes ElevatedSelf-grooming in Male Rat Offspring: Involvement of Abnormal Postpartum Static Nursing in Dam. Frontiers Cell and Developmental Biology Mar 16;11:1054381. doi: 10.3389/fcell.2023.1054381. eCollection (2023) IF (6,0)

(259) Zimyanin V, Pielka AM, Glaß H, Martin M, Deussen A, Szewczyk B, Deppmann C, Zunder E, Boeckers TM, Sterneckert J, Redemann St, Storch A, Hermann A In vivo imaging of ATP levels reveals metabolic compartmentalization within motoneurons and early metabolic changes in FUS ALS motoneurons. Cells 12, 1352. https:// (2023) IF (7,6)

(260) Rajkumar S, Böckers TM, Catanese A. Fast and efficient synaptosome isolation and post-synaptic density enrichment from hiPSC-motor neurons by biochemical sub-cellular fractionation. STAR Protoc. Jan 25;4(1):102061. doi: 10.1016/j.xpro.2023.102061. (2023)

(261) Pagano J, Landi S, Stefanoni A, Nardi G, Albanesi M, Bauer HF, Pracucci E, Schön M, Boeckers TM, Sala C, Verpelli Ch Shank3 deletion in PV neurons is associated with abnormal behaviors and neuronal functions that are rescued by increasing GABAergic signaling. Mol Autism Aug 1;14(1):28. doi: 10.1186/s13229-023-00557-2 (2023) IF (6,5)

(262) Aousji O, Feldengut S, Antonucci St, Schön M, Boeckers TM, Matschke J, Mawrin Ch, Ludolph AC, Del Tredici K, Roselli F, Braak H Patterns of synaptic loss in human amyotrophic lateral sclerosis spinal cord: a clinicopathological study. Acta Neuropathologica Com Jul 25;11(1):120. doi: 10.1186/s40478-023-01616-8 (2023) IF (7,8)

(263) Aly A, Laszlo ZI, Rajkumar S, Demir T, Hindley N, Lamont DJ, Lehmann J, Seidel M, Sommer D, Franz-Wachtel M, Barletta F, Heumos S, Czemmel St, Kabashi E, Ludolph A, Boeckers TM, Henstridge CM, Catanese A Integrative proteomics highlight presynaptic alterations and c-Jun misactivation as convergent pathomechanisms in ALS. Acta Neuropathologica Sep;146(3):451-475. doi: 10.1007/s00401-023-02611-y (2023) (15,8)

(264) Seidel M, Rajkumar S, Steffke C, Noeth V, Agarwal S, Roger K, Lipecka J, Ludolph A, Guerrera GI, Boeckers TM, Catanese A Propranolol reduces the accumulation of cytotoxic aggregates in C9orf72-ALS/FTD in vitro models. Curr Research in Neurobiology Jul 30;5:100105. doi: 10.1016/j.crneur.2023.100105. eCollection 2023. (2023) (6,3)

(265) Yildiz B, Schiedt L, Mulaw M, Bockmann J, Jesse S, Lutz A, Boeckers TM Muscular hypotonia in Shank3 related ASD is accompanied by increased intracellular Calcium concentrations and ion channel dysregulation. Front Cell Develop Biology Jul 30;5:100105. doi: 10.1016/j.crneur.2023.100105. eCollection 2023 (2023) (6,1)

(266) Jesse S, Müller HP, Huppertz HJ, Andres S, Ludolph AC, Schoen M, Boeckers TM, Jan Kassubek Neurodegeneration or dysfunction in Phelan McDermid Syndrome? – A multimodal approach with CSF and computational MRI. Orphanet J Rare Dis. Sep 5;18(1):274. doi: 10.1186/s13023-023-02863-7 (2023) IF (3,6)

(267) Bramham CR, Lessmann V, Hannan AJ, Wang C, Catanese A, Boeckers TM, Zhang H Editorial: Synaptopathies: from bench to bedside. Front. Synaptic Neurosci. 15:1291163. doi: 10.3389/fnsyn.2023.1291163 (2023) IF (3,7)

(268) Woelfle S, Pedro M, Wagner J, Schoen M, Boeckers TM Expression profiles of the autism-related releated SHANK proteins in the human brain. BMC Biology 13;21(1):254. doi: 10.1186/s12915-023-01712-0. (2023) IF (7,4)

(269) Giona F, Beretta St, Zippo A, Vicidomini C, Sala M, Jones CK, Conn PJ, Boeckers TM, Sala C, Verpelli Ch Decreased expression of ribosomal protein Rpl3 contributes to behavioral deficits caused by Shank3 deficiency. (in revision)

(270) Vinci E, Beretta St, Zippo A, Catanese A, Wiegreffe Ch, Britsch St, Boeckers TM, Verpelli Ch, Sala C Regulation of dendrite and dendritic spine formation by TCF20. (in revision)

(271) Ioannidis V, Pandey R, Bauer H, Schoen M, Bockmann J, Boeckers TM, Lutz A Disrupted extracellular matrix and cell cycle genes in autism-associated Shank3 deficiency are targeted by Lithium. Mol Psychiatry Dec 20. doi: 10.1038/s41380-023-02362-y. (2023) IF (15,9)


(236) Phelan K; Boccuto L; Powell C; Boeckers T; van Ravenswaaij-Arts C; Rogers C; Sala C; Verpelli Ch; Thurm A; Bennett W; Winrow Ch; Garrison S; Toro R; Bourgeron Th Phelan-McDermid syndrome: a classification system after 30 years of experience. Orphanet J Rare Dis 17, 27 (2022) IF (3,7)

(237) Meyer zu Reckendorf S, Moser D, Blechschmidt A, Neeha Joga V, Sinske D, Hegler J, Deininger St, Catanese A, Vettorazzi S, Antoniadis G, Boeckers T, Knöll B Motoneuron-specific PTEN deletion in mice induces neuronal hypertrophy and also regeneration after facial nerve injury. J Neuroscience JN-RM-1305-21 (2022) IF (6,1)

(238) Grohs-Metz G, Smausz R, Gigg J, Boeckers T, Hengerer B Functional ultrasound imaging of recent and remote memory recall in the associative fear neural network in mice. Behavioural Brain Research 25;428:113862. doi: 10.1016/j.bbr.2022.113862 (2022), IF (3,3)

(239) Lutz A-K, Bauer HF, Ioannidis V, Schön M, Boeckers TM SHANK3 antibody validation - differential performance in Western Blotting, immunocyto- and immunohistochemistry. Frontiers in synaptic neuroscience 6;14:890231. doi: 10.3389/fnsyn.2022.890231. (2022) IF (4,5)

(240) Sommer D, Rajkumar S, Seidel M, Aly A, Ludolph A, Ho R, Boeckers TM, Catanese A Aging-dependent altered transcriptional programs underlie activity impairments in human C9orf72-mutant motor neurons. Front in Mol Neuroscience 14;15:894230. doi: 10.3389/fnmol.2022.894230 (2022) IF (5,6)

(241) Malara M, Lutz AK, Incearap B, Bauer HF, Cursano S, Volbracht K, Lerner JJ, Pandey R, Delling JP, Ioannidis V, Arévalo AP, Eugenin von Bernhardi J, Schön M, Bockmann J, Dimou L, Boeckers TM SHANK3 deficiency leads to myelin defects in the central and peripheral nervous system. Cell and Mol Life Sciences 20;79(7):371. doi: 10.1007/s00018-022-04400-4. (2022) IF (9,7)

(242) Urrutia-Ruiz C, Rombach D, Cursano S, Gerlach-Arbeiter S, Schoen M, Bockmann J, Demestre M, Boeckers TM Deletion of the autism-associated protein SHANK3 abolishes structural synaptic plasticity after brain trauma. Int J of Mol Sciences 23, 6081 (2022) IF (6,0)

(243) Zhang J, Li Z, Chandrasekar A, Li S, Ludolph A, Boeckers TM, Huber-Lang M, Roselli F, Olde Heuvel F. Fast maturation of splenic dendritic cells upon TBI is associated with Flt3/Flt3L signaling. Front Immunol. 24;13:824459 (2022) IF (6,5)

(244) Garrido D, Beretta St, Grabrucker St, Bayer D, Sala C, Verpelli C, Roselli F, Proepper Ch, Bockmann J, Catanese A, Boeckers TM Shank2/3 double knockout-based screening links the retrosplenial area to the loss of social memory in autism spectrum disorders. Mol Psychiatry doi: 10.1038/s41380-022-01756-8 (2022) IF (15,9)

(245) Fröhlich A, olde Heuvel F, Rehman R, Sankari Krishnamurthy S, Li S, Li Z, Bayer D, Conquest A, Hagenston AM, Ludolph A, Huber-Lang M, Boeckers TM, Knöll B, Morganti-Kossmann MC, Bading H, Roselli F Neuronal nuclear calcium signaling suppression of microglial reactivity is mediated by osteoprotegerin after traumatic brain injury. Journal of Neuroinflammation 19, 279 (2022) IF (9,5)

(246) Pérez Arévalo A, Atanasova E, Lutz A-K, Boeckers T Trans-cardiac perfusion of neonatal mice and immunofluorescence of the whole body as a method to study nervous system development Plos One 13;17(10):e0275780. doi: 10.1371 (2022) IF (3,75)

(247) Rehman R, Miller M, Elsayed L, Kjell J, olde Heuvel F, Chandrasekar A, Ludolph A, Boeckers TM, Mulaw MA, Goetz M, Takeoka A, Roselli F cMet/HGFR triggers detrimental microglia neuroinflammation in TBI. Cell Reports 41(13):111867. doi: 10.1016/j.celrep.2022.111867. (2022) IF (9,9)


(235) Daini E, Hagmeyer S, De Benedicits CA, Cristóvão JS, Bodria M, Raab A, Boeckers TM, Feldmann J, Gomes CM, Zoli M, Vilella A, Grabrucker AM S100B dysregulation during brain development affects synaptic SHANK protein networks via alteration of zinc homeostasis. Transl Psychiatry 11, 562 (2021)

(234) Woelfle S, Boeckers TM Layer-specific VGLUT1 immunofluorescence levels delineate all layers of the human hippocampus including the stratum lucidum. Frontiers in Cellular Neuroscience 508 (2021)

(233) Delling JP and Boeckers TM Comparison of SHANK3-deficiency in animal models: Phenotypes, treatment strategies and translational implications. J Neurodevelopmental Disorders (2021) 13(1) 13-37

(232) Sauer A, Malijauskaite S, Meleady P, Boeckers TM, McGourty K, Grabrucker A Zinc is a key regulator of gastrointestinal development, microbiota composition and inflammation with relevance for Autism Spectrum Disorders. Cellular and Molecular Life Sciences (2021) 1-18

(231) Li Z, Zhang J, Halbgebauer, Chandrasekar A, Rehman R, Ludolph A, Boeckers T, Huber-Lang M, Otto M, Roselli F, Olde Heuvel F Differential effect of ethanol intoxication on peripheral markers of cerebral injury in murine blunt traumatic brain injury. Burns Trauma 10.1093/burnst/tkab027. eCollection (2021)

(230) Schön M*, Nosanova A, Jacob C, Kraus JM, Kestler HAK, Mayer B, Feldengut S, Amunts K, Del Tredici K, Boeckers TM*, Braak H A comparative study of pre-alpha islands in the entorhinal cortex from selected primates and in lissencephaly. J Comp Neurology doi: 10.1002/cne.25233. (2021)  *corresponding

(229) Lutz A-K, Pérez Arévalo A, Ioannidis V, Stirmlinger N, Demestre M, Delorme R, Bourgeon Th, Boeckers TM SHANK2 mutations result in dysregulation of the ERK1/2 pathway in human iPSC-derived neurons and Shank2(-/-) mice. Frontiers in Molecular Neuroscience 14 doi:10.3389/fnmol.2021.773571 (2021)

(228) Prelli Bozzo C, Nchioua R, Volcic M, Koepke L, Krüger J, Schütz D, Heller S, Stürzel Ch, Kmiec D, Conzelmann C, Müller J, Zech F, Braun E, Groß R, Wettstein L, Weil T, Weiß J, Diofano F, Rodríguez Alfonso A, Wiese S, Sauter D, Münch J, Goffinet Ch, Catanese A, Schön M, Boeckers T, Stenger St, Sato K, Just St, Kleger A, Sparrer K, Kirchhoff F IFITM proteins promote SARS-CoV-2 infection 2 and are targets for virus inhibition in vitro. Nature Com 12 (1), 1-13 (2021)

(227) Rehman R, Tar L, Olamide A, Li Z, Kassubek J, Boeckers TM, Weishaupt J, Ludolph AC, Wiesner D, Roselli F Acute TBK1/IKK-e inhibition enhances the generation of disease- associated microglia upon traumatic brain injury. Frontiers in Aging Neuroscience doi: 10.3389/fnagi.2021.684171 (2021)

(226) Jesse S, Delling JP, Schön M, Boeckers TM, Ludolph A, Senel M Genetic autism-spectrum disease – Multiple Sclerosis as a rare but treatable cause for regression in Phelan McDermid Syndrom. Int J Mol Sci. 25;22(5):2311. doi: 10.3390/ijms22052311 (2021)

(225) Catanese A, Rajkumar S, Freisem D, Wirth A, Torelli F, Sommer D, Ioannidis V, Lipeck J, Guerrera IC, Zytnicki D, Ludolph A, Kabashi E, Roselli F, Boeckers TM CREB-regulated transcription and synaptic stability are disrupted in iPS derived ALS motoneurons. EMBO Molecular Medicine (2021)

(224) Pal A, Kretner B, Abo-Rady M, Glaß H, Sczech R, Japtok J, Boeckers TM, Sterneckert J, Hermann A Concomitant gain and loss of function pathomechanisms in C9ORF72 amyotrophic lateral sclerosis. Life Science Alliance 22;4(4):e202000764. doi: 10.26508/lsa.202000764. (2021)

(223) Mossa A, Pagano J, Ponzoni L, Tozzi A, Vezzoli E, Francolini M, Sala M, Calabresi P, Boeckers TM, Sala C, Bretta St., Sciaccaluga M and Verpelli Ch Developmental impaired Akt signaling in the Shank1 and Shank3 double knock-out mice. Mol Psychiatry doi: 10.1038/s41380-020-00979-x (2021)

(222) Freischmidt A, Goswami A, Limm K, Zimyanin VL, Demestre M., Holzmann Kh, Helferich AM, Tripathi P, Yamoah A, Oefner PJ, Boeckers TM, Aronica E, Ludolph AC, Andersen PM, Hermann A, Weis J, Reinders J, Danzer K, Weishaupt JH A serum microRNA sequence reveals Fragile X protein pathology in amyotrophic lateral sclerosis. Brain 7;144(4):1214-1229. doi: 10.1093/brain/awab018 (2021)

(221) Grabrucker St, Pagano J, Schweizer J, Schön M, Bockmann J, Ehret G, Grabrucker AM, Hengerer B, Verpelli Ch, Sala C, Boeckers TM
Activation of the medial preoptic area (MPOA) ameliorates loss of social bonding in a Shank2 mouse model for autism. EMBO J e104267. doi: 10.15252/embj.2019104267. (2021)

(220) Cursano S, Urrutia-Garrado C, Grabrucker St, Schoen M, Bockmann J, Braumüller S. Roselli F., Radermacher P, Huber-Lang M, Boeckers TM
CRHR1 antagonists prevent hippocampal synaptic loss and memory deficits in a mouse model for a trauma associated, delirium-like syndrome. Mol Psychiatry Feb 12. doi: 10.1038/s41380-020-0659-y (2021)

(220) Cursano S, Urrutia-Garrado C, Grabrucker St, Schoen M, Bockmann J, Braumüller S. Roselli F., Radermacher P, Huber-Lang M, Boeckers TM CRHR1 antagonists prevent hippocampal synaptic loss and memory deficits in a mouse model for a trauma associated, delirium-like syndrome. Mol Psychiatry Feb 12. doi: 10.1038/s41380-020-0659-y (2021)


(208) Chandrasekar A, olde Heuvel F, Tar L, Hagenston AM, Palmer A, Linkus B, Ludolph AC, Huber-Lang M, Boeckers TM, Bading H, Roselli F Parvalbumin interneurons shape neuronal vulnerability in blunt TBI. Cerebral Cortex 1;29(6):2701-2715 (2019)

(209) Bursch F., Kalmbach N., Naujock M., Staege S., Eggenschwiler R., Abo-Rady M., Japtok J., Guo W., Reinhardt P., Boeckers T., Cantz, Sterneckert J., Van Den Bosch L., Hermann A., Petri S., Wegner F. Altered calcium dynamics and glutamate receptor properties in iPSC derived motor neurons from ALS patients with C9orf72, FUS, SOD1 or TDP43 mutations. Human Molecular Genetics 1;28(17):2835-2850 (2019)

(210) Deshpande D, Higelin J, Schoen M, Vomhof Th, Boeckers TM, Demestre M, Michaelis J Synaptic FUS localization during motoneuron development and its accumulation in human ALS synapses. Front Cell Neuroscience 12;13:256. doi: 10.3389/fncel.2019.00256. eCollection (2019)

(211) Pichiarelli G, Demestre M, Mersmann S, Mallik M, Higelin J, Dieterlé St, Goy M, Zhang L, Sellier C, Scekic-Zahirovic J, Rosenbohm A, Wagner M, Sanjuan-Ruiz I, Messadeq N, van Bakel N, Boutillier A, Ludolph A, Lagier-Tourenne C, Boeckers TM*, Dupuis L*, Storkebaum E* FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis. Nature Neuroscience, 22(11):1793-1805. (2019) *corresponding authors

(212) Jesse S, Müller HP, Schoen M, Asoglu H, Bockmann J, Huppertz HJ, Rasche V, Ludolph AC, Boeckers TM, Kassubek J Severe white matter damage in SHANK3 deficiency: a human and translational study. Ann Clin Transl Neurology, doi: 10.1002/acn3.50959 (2019)

(213) Olde Heuvel F, Holl S, Chandrasekar A, Li Z, Wang Y, Rehman R, Förstner P, Sinske D, Palmer A, Wiesner D, Ludolph A, Huber-Lang M, Relja B, Wirth T, Röszer T, Baumann B, Boeckers T, Knöll B, Roselli F. STAT6 mediates the effect of ethanol on neuroinflammatory response in TBI. Brain Behav Immun. 81:228-246. (2019)

(214) Ey E, Bourgeon Th, Boeckers TM, Kim E, Han K Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases. Frontiers in Molecular Neuroscience 13:11. doi: 10.3389/fnmol.2020.00011 (2020)

(215) Lutz AK, Pfaender St, Incearap B, Ioannidis V, Ottonelli I, Föhr K, Cammerer J, Zoller M, Higelin J, Giona F, Stetter M, Stoecker N, Ouali Alami N, Schön M, Orth M, Liebau St, Barbi G, Grabrucker AM, Delorme R, Fauler M, Mayer B, Jesse S, Roselli F, Ludolph AC, Bourgeron Th, Verpelli C, Demestre M and Boeckers TM
Autism-associated SHANK3 mutations lead to impaired maturation of hiPSC derived motor unit components. Science Transl. Medicine 12 (547) (2020)

(216) Bouquier, Moutin, Tintignac, Reverbel A, Jublanc E, Sinnreich M, Chastagnier Y, Averous J, Fafournoux P, Verpelli Ch, Boeckers TM, Carnac G, Perroy J, Ollendorff V AIMTOR, a live BRET biosensor revealssubcellular mTOR signaling and dysfunctions. BMC Biology 18 (1), 1-17 (2020)

(217) Culotta L, Scalmani P, Vinci E, Terragni B, Sessa B, Broccoli V, Mantegazza M, Boeckers T, Verpelli C SULT4A1 Modulates Synaptic Development and Function by Promoting the Formation of PSD-95/NMDAR Complex Journal of Neuroscience 40(37):7013–7026 • 70138 (2020) IF

(218) Ouali Alami A, Tang L, Wiesner D, Commisso B, Bayer D, Weishaupt J, Dupuis L, Wong P, Baumann B, Wirth Th, Boeckers TM, Yilmazer-Hanke D, Ludolph A, Roselli F Multiplexed chemogenetics in astrocytes and motoneurons restore Blood-Spinal Cord-Barrier in ALS. Life Science Alliance (2020)

(219) Battaglia CR, Cursano S, Calzia E, Catanese A, Boeckers TM Corticotropin Releasing Hormone (CRH) alters mitochondrial morphology and function by activating the NF-kB-DRP1 axis in hippocampal neurons. J Cell Death and Disease 11:1004 (2020)


(203) Catanese A, olde Heuvel F, Mulaw M, Demestre M, Higelin J, Barbi G, Weishaupt JH, Ludolph AC, Roselli F, Boeckers TM Retinoic acid worsens Atg10-dependent autophagy impairment in TBK1-mutant hiPSC-derived motoneurons through p62 accumulation. Autophagy (in press)

(204) Chandrasekar A, olde Heuvel F, Tar L, Hagenston AM, Palmer A, Linkus B, Ludolph AC, Huber-Lang M, Boeckers TM, Bading H, Roselli F Parvalbumin interneurons shape neuronal vulnerability in blunt TBI. Cerebral Cortex (in press)

(205) Changuk Chung, Seungmin Ha, Hyojin Kang, Jiseok Lee, Seung Min Um, Haidun Yan, Ye-Eun Yoo, Taesun Yoo, Hwajin Jung, Dongwon Lee, Eunee Lee, Seungjoon Lee, Jihye Kim, Ryunhee Kim, Yonghan Kwon, Woohyun Kim, Hyosang Kim, Lara Duffney, Doyoun Kim,Won Mah, Hyejung Won, Seojung Mo, Jin Yong Kim, Chae-Seok Lim, Bong-Kiun Kaang, Tobias M. Boeckers, Yeonseung Chung, Hyun Kim, Yong-Hui Jiang, and Eunjoon Kim Early correction of NMDAR function improves autistic-like behaviors in adult Shank2-/- mice. Biological Psychiatry (in press)

(206) Schoen M, Asoglu H, Abaei A, Sauer AK, Bockmann J, Rasche V, Grabrucker AM, Boeckers TM SHANK3 transgenic and prenatal zinc-deficient autism mouse models show convergent and individual alterations of brain structures in MRI. Front in Neural Circuits (in press)

(207) Song TJ, Lan X, Wei MP, Zhai FJ, Boeckers TM, Wang JN, Yuan S, Jin MY, Xie YF, Dang WW, Zhang C, Schön M, Song PW, Qiu MH, Han SP, Han JH, Zhang R Altered Behaviors and Impaired Synaptic Function in a Novel Rat Model with a Complete Shank3 Deletion. Front Cell Neuroscience (in press)


Naumann M, Pal A, Goswami A, Lojewski X, Japtok J, Vehlow A, Naujock M, Günther R, Jin M, Stanslowsky N, Reinhardt P, Sterneckert J, Frickenhaus M, Pan-Montojo F, Storkebaum E, Poser I, Freischmidt A, Weishaupt J, Holzmann KH, Troost D, Ludolph A, Boeckers TM, Liebau St, Petri S, Cordes N, Hyman A, Wegner F, Stephan G, Weis J, Storch A, and Hermann A Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and aggregation formation. Nature Communication 9:335 (2018)

Grabrucker St, Haderspeck JC, Sauer AK, Kittelberger N, Asoglu H, Abaei A, Rasche V, Schoen M, Boeckers TM , Grabrucker AM Brain lateralization in mice is altered in the prenatal zinc deficient mouse model for autism spectrum disorders. Front in Mol Neuroscience 15;10:450. doi: 10.3389/fnmol.2017.00450 (2018)

Hagmeyer S, Cristóvão JS, Mulvihill JJ, Boeckers TM, Gomes CM, Grabrucker AM Zinc binding to S100B affords regulation of trace metal homeostasis and excitotoxicity in the brain. Front in Mol Neuroscience 10:456. doi: 10.3389/fnmol.2017.00456. eCollection 2017 (2018)

Chandrasekar A, Aksan B, olde Heuvel F, Förstner P, Sinske D, Palmer A, Rehman R, Ludolph A, Huber-Lang M, Boeckers T, Mauceri D, Knoell B, Roselli F Neuroprotective effect of acute ethanol intoxication in TBI is associated to the hierarchical modulation of early transcriptional responses. Experimental Neurology (2018)

Rizzo F., Nespoli E., Abaei A., Bar-Gad I., Fegert J, Rasche V., Hengerer B., Boeckers T.M. Aripiprazole treatment selectively reduces motor tics in an animal model for Tourette’s Syndrome and comorbid ADHD. Front in Neurology (2018)

Hesse R, von Einem B, Wagner F, Schwanzar D, Jackson RJ, Föhr K, Lausser L, Kroker KS, Proepper C, Walther P, Kestler HA, Spires-Jones TL, Boeckers T, Rosenbrock H, von Arnim CAF sAPPβ and sAPPα increase structural complexity and synapse morphology in primary hippocampal neurons by altering Ca2+ homeostasis and CREB1-signaling. Experimental Neurology (in press)

Ponna SK, Ruskamo S, Myllykoski M, Keller C, Boeckers TM, Kursula P Structural basis for PDZ domain interactions in the post-synaptic density scaffolding protein Shank3. J Neurochem 145(6):449-463 (2018)

Modi M, Brooks J, Guillmette E, Graf R, Reim D, Schmeisser M, Boeckers TM, O’Donnell P, Buhl DL Hyperactivity and hypermotivation associated with increased striatal mGluR1 signalling in a Shank2 rat model of autism. Front in Cell Neuroscience 11:107 (2018)

Nespoli E, Rizzo F, Boeckers TM, Schulze U, Hengerer B Altered dopaminergic regulation of the dorsal striatum is able to induce tic-like movements in juvenile rats. Plos One (2018):e0196515. doi: 10.1371/journal.pone.0196515. eCollection 

Ouali Alami N, Schurr Ch, olde Heuvel F, Li Q, Tasdogan A, Kimbara A, Nettekoven M, Ottaviani G, Raposo C, Röver St, Rogers-Evans M, Rothenhäusler B, Ullmer Ch, Fingerle J, Grether U, Knuesel I, Boeckers T, Ludolph A, Wirth Th, Roselli F, Baumann B NF-ᴋB activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALS. EMBO J 37(16) (2018)

Chandrasekar A, olde Heuvel F, Palmer A, Linkus B, Ludolph AC, Boeckers TM, Relja, B, Huber-Lang M, Roselli F The neuroprotective effect of ethanol intoxication in TBI is associated with the suppression of ErbB signaling in PV-positive interneurons. J Neurotrauma 35(22) :2718-2735 (2018)

Heise C, Preuss JM, Schroeder JC, Battaglia Ch, Kolibius J, Schmid R, Kreutz MR, Kas MJH, Burbach PH, Boeckers TM Heterogeneity of cell surface glutamate and GABA receptors expression in Shank and CNTP4 autism mouse models. Front in Mol Neuroscience 11:212 (2018)

Higelin J, Catanese A, Semelink-Sedlacek LL, Oeztuerk S, Lutz AK, Bausinger J, Barbi G, Andersen PM, Ludolph AC, Demestre M, Boeckers TM NEK1 loss-of-function mutation induces DNA damage accumulation in ALS patient-derived motoneurons. Stem Cell Research 30:150162 (2018)

Catanese A, Garrido C D, Walther P, Roselli F, Boeckers TM Nutrient limitation affects presynaptic structures through dissociable Bassoon autophagic degradation and impaired vesicle release. Journal of Cerebral Blood Flow and Metabolism 38(11):1924-1939 (2018)

Comisso B., Ding L., Varadi K., Gorges M., Bayer D., Boeckers TM, Ludolph A., Kassubek J., Mueller O., Roselli F. Stage-dependent remodeling of projections to motor cortex in ALS mouse model revealed by a new variant retrograde-AAV9. Elife 7 (2018)

Ey E, Torquet N, de Chaumont F, Lévi-Strauss J, Ferhat A, Le Sourd AM, Boeckers TM, Bourgeron Th Shank2 mutant mice display hyperactivity insensitive to methylphenidate and reduced flexibility in social motivation, but normal social recognition. Front in Behavioural Neuroscience 11:365 (2018)

Yu-Chuan Dai, Hong-Feng Zhang, Michael Schön, Tobias Maria Boeckers, Song-Ping Han, Ji-Sheng Han, Rong Zhang, Neonatal Oxytocin Treatment Ameliorates Autistic-Like Behaviors and Oxytocin Deficiency in Valproic Acid-Induced Rat Model of Autism. Front Cell Neuroscience 12:355 (2018)


Bayer H, Lang K, Barth E, Higelin J, Barteczko L, Pasquarelli N, Sprissler J, Lucas T, Holzmann KH, Demestre M, Lindenberg K, Danzer K, Boeckers TM, Ludolph AC, Dupuis L, Weydt P, Witting A ALS-causing mutations differentially affect PGC-1α expression and function in the brain vs. peripheral tissues. Neurobiology of Disease 97(Pt A):36-45 (2017)

Lim CS, Kim H, Yu NK, Kang SJ, Kim T, Ryu HR, Park T, Gim J, Nam HJ, Baek SH, Wegener St, Schmitz D, Boeckers TM, Lee MG, Kim E, Lee JH, Lee YS, Kaang BK Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice. Neuropharmacology 112(Pt A):104-112 (2017)

Vicidomini C., Ponzoni L., Lim D, Schmeisser M, Reim D, Morello N, Orelanna D, Tozzi A, Durante V, Scalmani P, Mantegazza M, Genazzani AA, Giustetto M, SalaM, Calabresi P, Boeckers TM, Sala C, Verpelli C Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits found in SHANK3 knock-out mice. Mol Psychiatry 22(5):784 (2017)

Rothe M, Kanwal N, Dietmann P, Seigfried F, Hempel A, Schütz D, Reim D, Engels R, Linnemann A, Schmeisser MJ, Bockmann J, Kühl M, Boeckers TM*, Kühl S*, An Ephrin/SPAR3-SIPA1L3/Wnt pathway regulates eye development and lens maturation. Development 144, 321-333 (2017) *corresponding

Peter S, De Zeeuw CI, Boeckers TM, Schmeisser MJ Cerebellar and Striatal Pathologies in Mouse Models of Autism Spectrum Disorder. Adv Anat Embryol Cell Biol. 224:103-119 (2017)

Lilja J, Zacharchenko Th, Georgiadou M, Jacquemet G, De Franceschi N, Peuhu E, Pouwels J, Beifuss M, Boeckers TM, Kreienkamp HJ, Barsukov I, Ivaska J SHANK3 structure reveals a RAS-associated domain regulating integrin activation. Nature Cell Biology 19(4):292-305 (2017)

Reim D, Distler U, Halbedl S, Verpelli Ch, Sala C, Bockmann J, Tenzer St, Boeckers TM*, Schmeisser MJ* Proteomic analysis of postsynaptic density fractions from Shank3 mutant mice reveals brain region specific changes relevant to autism spectrum disorder. Front in Molecular Neuroscience 14;10:26 *corresponding (2017)
Pfaender St, Sauer AK, Hagmeyer S, Mangus K, Linta L, Liebau St, Bockmann J, Huguet G, Bourgeron Th, Boeckers TM, Grabrucker A Zinc deficiency and low enterocyte zinc transporter expression in human patients with autism related mutations in SHANK3 Scientific Reports 27;7:45190 (2017)

Vicidomini C, Ponzoni L, Lim D, Schmeisser MJ, Reim D, Morello N, Orellana D, Tozzi A, Durante V, Scalmani P, Mantegazza M, Genazzani AA, Giustetto M, Sala M, Calabresi P, Boeckers TM, Sala C, Verpelli C Homer1b/c clustering is impaired in Phelan-McDermid Syndrome iPSCs derived neurons. Mol Psychiatry 22(5):637 (2017)

Chandrasekar A, olde Heuvel F, Palmer A, Linkus B, Ludolph AC, Boeckers TM, Relja B, Huber-Lang M, Roselli F Acute ethanol administration results in a protective cytokine and neuroinflammatory profile in traumatic brain injury. International Immunopharmacology 51; 66–75 (2017)

Sarowar T, Grabrucker St, Boeckers TM, Grabrucker AM Object phobia and altered RhoA signaling in amygdala of mice lacking RICH2. Front Mol Neuroscience 8;10:180 (2017)

Rizzo F., Abaei A., Nespoli. E., Fegert J. M., Hengerer B., Rasche V., Boeckers TM Aripiprazole and Riluzole treatment alters behavior and neurometabolites in young ADHD rats: A longitudinal 1H-NMR spectroscopy study at 11.7T. Translational Psychiatry 1;7(8):e1189 (2017)

Ponna SK, Myllykoski M, Boeckers TM, Kursula P Structure of an unconventional SH3 domain from the postsynaptic density protein Shank3 at sub-atomic resolution. BBRC 26;490(3):806-812 (2017)

Sauer AK, Pfaender St, Hagmeyer S., Tarana L, Mattes AK, Briel F, Küry S, Boeckers TM, Grabrucker A Characterization of zinc amino acid complexes for zinc delivery in vitro using Caco-2 cells and enterocytes from hiPSC. Biometals 30(5):643-661 (2017)


Dolnik A, Kanwal N, Mackert S, Halbedl S, Proepper Ch, Bockmann J, Schoen M, Boeckers TM, Kühl SJ, Schmeisser MJ Sipa1l3/SPAR3 is targeted to postsynaptic specializations and interacts with the Fezzin ProSAPiP1/Lzts3. J Neurochem. 136(1):28-35 (2016)

Schroeder JC, Reim D, Boeckers TM, Schmeisser MJ Genetic animal models for autism spectrum disorder. Current Topics in Behavioral Neurosciences (2016) (IF 0)

Halbedl S, Schoen M, Feiler M, Boeckers TM, Schmeisser MJ Shank3 is localized in axons and presynaptic specializations of developing hippocampal neurons and involved in the modulation of NMDA receptor levels at axon terminals. J Neurochem 137(1):26-32 (2016)

Naujock M, Stanslowsky N, Bufler S, Naumann M, Reinhardt M, Sterneckert J, Kassebaum C, Lojewski X, Storch A, Frickenhaus M, Boeckers TM, Putz St, Demstre M, Liebau St, Klingenstein M, Ludolph A, Dengler R, Kim K, Hermann A, Wegner F, Petri S Aminopyridine induced activity rescues hypoexcitable ALS iPSC-derived motor neurons. Stem Cells 34(6):1563-75 (2016)

Schoen M, Reichel J, Demestre M, Putz St, Deshpande D, Proepper Ch, Liebau St, Schmeisser MJ, Ludolph AC, Michaelis J, Boeckers TM Super-resolution microscopy reveals presynaptic localization of the ALS / FTD related protein FUS in hippocampal neurons. Front Cell Neurosci 12;9:496 (2016)

Grabrucker St, Boeckers TM, Grabrucker AM Gender dependent evaluation of autism like behavior in mice exposed to prenatal zinc deficiency. Front Behav Neurosci 3;10:37 (2016)

Sarowar T, Grabrucker St, Föhr K, Mangus K, Eckert M, Bockmann J, Boeckers TM*, Grabrucker AM* Enlarged dendritic spines and pronounced neophobia in mice lacking the PSD protein Rich2. Mol Brain 11;9(1):28 (2016) *corresponding

Nespoli E, Rizzo F, Boeckers TM, Hengerer B, Ludolph AG Addressing the complexity of Tourette’s syndrome through the use of animal models. Front in Neuroscience 8;10:133 (2016)

Pfaender St, Föhr KJ, Lutz AK, Putz St, Achberger K, Linta L, Liebau St, Boeckers TM, Grabrucker AM Cellular zinc homeostasis contributes to neuronal differentiation in human induced pluripotent stem cells. Neural Plasticity, Article ID 3760702, doi:10.1155/2016/3760702 (2016)

Heise C, Schroeder JC, Schoen M, Halbedl S, Reim D, Woelfle S, Kreutz MR, Schmeisser MJ, Boeckers TM Selective localization of Shanks to VGLUT1-positive excitatory synapses in the mouse hippocampus. Front Cell Neurosci 10:106. doi: 10.3389/fncel.2016.00106 (2016)

Reim D, Weis TM, Halbedl S, Grabrucker AM, Boeckers TM*, Schmeisser MJ*, The Shank3 interaction partner ProSAPiP1 regulates postsynaptic SPAR levels and the maturation of dendritic spines in hippocampal neurons. Front Synaptic Neurosci 8:13. doi: 10.3389/fnsyn.2016.00013 (2016)  *corresponding

Ponna SK, Myllykoski M, Boeckers TM, Kursula P Sub-atomic resolution X-ray diffraction of the SH3 domain from the post-synaptic density protein Shank3. BioRxiV doi: (2016)

Liu X, Huai J, Endle H, Schlüter L, Wei F, Yunbo L, Haichao J, Rister B, Horta G, Baumgart J, Berger H, Schmitt U, Schmeisser MJ, Boeckers TM, Deller Th, Vlachos A, Tenzer St, Nitsch R, Vogt J PRG-1 regulates spine density and memory via intracellular PP2A/ß1-integrin signaling. Developmental Cell S1534-5807(16)30422-1 (2016)
Peter S, ten Brinke MM, Stedehouder J, Reinelt CM, Wu B, Zhou H, Zhou K, Boele HJ,  Kushner SA, Lee MG, Schmeisser MJ, Boeckers TM, Schonewille M, Hoebeek FE, De Zeeuw CI Dysfunctional cerebellar Purkinje cells contribute to autism-like behaviour in Shank2-deficient mice. Nature Commun 1;7:12627 (2016)

Sarowar T, Chhabra R, Vilella A, Boeckers TM, Zoli M, Grabrucker AM Activity and circadian rhythm influence synaptic Shank3 protein levels in mice. J Neurochem (2016) 22. doi: 10.1111/jnc.13709

Forde NJ, Kanaan AS, Widomska J, Padmanabhuni SS, Nespoli E, Alexander J,  Rodriguez Arranz JI, Fan S, Houssari R, Nawaz MS, Zilhão NR, Pagliaroli L, Rizzo F, Aranyi T, Barta C, Boeckers TM, Boomsma DI, Buisman WR, Buitelaar JK, Cath D, Dietrich A, Driessen N, Drineas P, Dunlap M, Gerasch S, Glennon J, Hengerer B,  van den Heuvel OA, Jespersgaard C, Möller HE, Müller-Vahl K, Openneer T, Poelmans G, Pouwels P, Scharf JM, Stefansson H, Tümer Z, Veltman D, van der Werf YD, Hoekstra PJ, Ludolph A and Paschou P TS-EUROTRAIN: A European-wide investigation and training network on the aetiology and pathophysiology of Gilles de la Tourette Syndrome. Front Neurosci (2016) 23;10:384

Higelin J, Demestre M, Putz St, Lutz AK, Bausinger J, Hübers AK, Klingenstein M, Barbi G, Liebau St, Speit G, Hermann A, Ludolph AC, Boeckers TM FUS mislocalisation and vulnerability to DNA damage in ALS patients derived hiPSCs and aging motoneurons. Front Cell Neuroscience 26;10:290 (2016)


 Peykov S, Berkel S, Schoen M, Weiss K, Degenhardt F, Strohmaier J, Weiss B, Proepper C, Schratt G, Nöthen MM, Boeckers TM, Rietschel M, Rappold GA Identification and functional characterization of rare SHANK2 variants in schizophrenia" Mol Psychiatry 6. doi: 10.1038/mp.2014.172. (2015)

Moujalled D, James JL, Yang S, Zhang K, Moujalled DM, Parker SJ, Caragounis A, Lidgerwood G, Turner BJ, Atkin JD, Grubman A, Liddell JR, Pröpper C, Boeckers TM, Kanninen KM, Blair I, Crouch PJ, White AR Phosphorylation of hnRNP K by cyclin-dependent kinase 2 controls cytosolic accumulation of TDP-43. Human Molecular Genetics 15;24(6):1655-69 (2015)

Hagmeyer S, Mangus K, Boeckers TM, Grabrucker AM Effects of Trace Metal Profiles characteristic for Autism on Synapses in Cultured Neurons," Neural Plasticity Article ID 985083 (2015)

Freischmidt A, Wieland Th, Richter B, Ruf W, Schäffer V, Müller K, Marroquin N, Nordin F, Hübers A, Weydt P, Pinto S, Press R, Millecamps St, Molko N, Bernard E, Desnuelle C, Soriani MH, Dorst J, Graf E, Nordström U, Feiler MS, Putz St, Boeckers TM, Meyer Th, Winkler AS, Winkelman J, de Carvalho M, Thal DR, Otto M, Brännström Th, Volk AE, Sarvari P, Stainier DYR, Kursula P, Danzer KM, Lichtner P, Dikic I, Meitinger Th, Ludolph AC, Strom TM, Andersen PM, Weishaupt JH TBK1 mutations confer susceptibility to amyotrophic lateral sclerosis and fronto-temporal dementia. Nature Neurosci 18(5):631-6 (2015)

Cochoy DM, Kajiwara Y, Schoen M, Lucas MP, Kolevzon A, Buxbaum JD, Boeckers TM, Schmeisser MJ Analysis of novel stop mutations in SHANK3 identified in patients with ASD or ID. Mol Autism 29;6:23 (2015)

von Einem B, Wahler A, Schips T, Serrano-Pozo A, Proepper Ch, Boeckers TM, Rueck A, Wirth Th, Hyman BT, Danzer KM, Thal D, von Arnim Ch The Golgi-localized γ-ear-containing ARF-binding(GGA) proteins alter amyloid-β precursor protein (APP) processing through interaction of their GAE domain with the beta-site APP cleaving enzyme 1 (BACE1). Plos One 8;10(6):e0129047 (2015)

Demestre M, Orth M, Foehr KJ, Achberger K, Ludolph AC, Liebau St, Boeckers TM Formation and characterisation of neuromuscular junctions between hiPSc derived motoneurones and myotubes. Stem Cell Research 26;15(2):328-336 (2015)

Japtok J, Lojewski X, Naumann M, Klingenstein M, Reinhardt P, Sterneckert J, Putz St, Demestre M, Boeckers TM, Ludolph AC, Liebau St, Storch A, Herrmann A Stepwise acquirement of hallmark neuropathology in FUS-ALS iPSC models depends on mutation type and neuronal aging. Neurobiology of Disease 82, 420-429 (2015)

Chhabra R, Ruozi B, Vilella B, Belletti D, Mangus K, Pfaender St, Sarowar T, Boeckers TM, Zoli M, Forni F, Vandelli MA, Tosi G, Grabrucker AM Application of polymeric nanoparticles for CNS targeted zinc delivery in vivo. CNS & Neurological Disorders-Drug Targets 14(8):1041-53 (2015)



Jannetti L, Grabrucker St, Eckert M, Chhabra R, Pfänder St, Mangus K, Ehret G, Boeckers TM, Grabrucker AM Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to the severity of autism spectrum disorders. Brain 137(Pt 1):137-52

Proepper C, Putz St, Boeckers TM, Liebau St The Kvβ2 subunit of voltage gated potassium channels is interacting with
ProSAP2/Shank3 in the PSD. Neuroscience 7;261:133-43 (2014)

Vilella A, Tosi G, Grabrucker AM, Ruozi B, Belletti D, Vandelli MA, Boeckers TM, Forni F, Zoli M Insight on the fate of CNS-targeted nanoparticles. Part I: Rab5-dependent cell-specific uptake and distribution Journal of Controlled Release 174;195–201 (2014)

Tosi G, Vilell A, Chhabra R, Schmeisser MJ, Boeckers TM, Ruozi B, Vandelli MA, Forni F, Zoli M, Grabrucker AM Insight on the fate of CNS-targeted nanoparticles. Part II: Intercellular neuronal cell-to cell transport, Journal of Controlled Release 10;177:96-107 (2014)

Raynaud F, Moutin E, Schmidt S, Dahl J, Bertaso F, Boeckers TM, Homburger V, Fagni L Rho-GTPase-activating protein interacting with
cdc-42 interacting protein 4 homolog 2 (Rich2) : a new Ras-related C3 botulinum toxin substrate 1 (Rac1) that controls dendritic spine morphogenesis. JBC 31;289(5):2600-9 (2014)

Kleijer K; Schmeisser M; Krueger D; Boeckers T; Scheiffele P; Bourgeron T; Brose N; Burbach J. P Neurobiology of autism gene
products: towards pathogenesis and drug targets. Psychopharmacology
231(6):1037-62 (2014)

Grabrucker St; Proepper C, Mangus K, Eckert M, Chhabra R, Schmeisser MJ, Boeckers TM, Grabrucker AM The PSD protein
ProSAP2/Shank3 displays synapto-nuclear shuttling which is deregulated in a schizophrenia - associated mutation. Exp Neurology 253:126-37

Chhabra R, Grabrucker AM, Veratti P, Belletti D, Boeckers TM, Vandelli MA, Forni F, Tosi G, Ruozi B: Characterization of lysosome-destabilizing DOPE/PLGA nanoparticles designed for cytoplasmic drug release. International Journal of Pharmaceutics 471
(1-2): 349-357 (2014)  

Leblond CS, Nava C, Polge A, Gauthier J, Huguet G, Lumbroso S, Giuliano F, Stordeur C, Depienne C, Mouzat K, Pinto D, Lemière N, Durand CC, Guibert J, Ey E, Toro R, Peyre H, Mathieu A, Rastam M, Gillberg IC, Rappold G, Holt R, Monaco AP, Maestrini E, Devillard F, Assouline B, Bonneau D, Regnault B, Zelenika D, Delepine M, Lathrop M, Sanlaville D, Edery P, Schmeisser MJ, Boeckers TM, Coleman M, Sato D, Szatmari P, Scherer SW, Rouleau G, Betancur C, Leboyer M, Gillberg Ch, Delorme R, Bourgeron Th Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: A Gradient of Severity in Cognitive Impairments.  
Plos Genet 4;10(9):e1004580 (2014)

Distler U, Schmeisser MJ, Pelosi A, Kuharev J, Baumgart J, Boeckers TM, Nitsch R, Vogt J, Tenzer St In-depth protein profiling of mouse hippocampal postsynaptic density using data-independent acquisition proteomics. Proteomics 14(21-22):2607-13. (2014)

Baecker T, Mangus K, Pfaender S, Chhabra R, Boeckers TM, Grabrucker AM: Loss of COMMD1 and copper overload disrupt zinc homeostasis and influence an autism-associated pathway at glutamatergic synapses. Biometals 27(4):715-30 (2014)


Schmeisser MJ and Boeckers TM Shank1 and Prosap1/Shank2 Mouse Models of Autism. Autism Volume 2, 4; 1000106 (2013)

Wahler A, Beyer AS, Keller IE, von Einem B, Pröpper Ch, Boeckers TM, Peltan ID, Strickland DK, Hyman BT, von Arnim CAF Engulfment adapter PTB domain containing 1 (GULP1) is a nucleocytoplasmic shuttling protein and transactivationally active together with low density lipoprotein receptor-related protein 1 (LRP1). Biochemical Journal 1;450(2):333-43 (2013)

Raynaud F, Janossy A, Dahl J, Bertaso F, Perroy J., Varrault A, Vidal M, Worley PF, Boeckers TM, Bockaert J, Marin J, Fagni L and Homburger V Shank3-Rich2 Interaction Regulates AMPA Receptor Recycling and Synaptic Long-term Potentiation. J Neurosci 5;33(23):9699-715

Kerstin Duning, Arne Bokemeyer, Dirk-Oliver Wennmann, Heike Wersching, Christian Thomas, Jens Buschert, Katrin Guske, Veronika Franzke, Stefan-Martin Brand, Agnes Flöel, Hubertus Lohmann, Stefan Knecht, Michaela Pöter, Ursula Rescher, Markus Missler, Carsten Reissner, Patrick Seelheim, Christian Pröpper, Tobias M. Boeckers, Lauren Makuch, Richard Huganir, Thomas Weide, Eva Brand, Hermann Pavenstädt and Joachim Kremerskothen Common exonic missense variants in the human KIBRA C2 domain modify lipid binding and cognitive performance. Translational Psychiatry 18;3:e272 (2013)

Leonhard Linta, Marianne Stockmann, André Lechel, Christian Proepper, Tobias Boeckers, Alexander Kleger and Stefan Liebau Microarray based expression comparison of ion channels between human keratinocytes and derived iPS cells. Stem Cells International, vol. 
2013, Article ID 784629 (2013)

Ey, E., Torquet, N., Le Sourd, A.-M., Leblond, C.S., Boeckers, T.M., Faure, P., Bourgeron, T. The Autism ProSAP1/Shank2 mouse model displays quantitative and structural abnormalities in ultrasonic vocalisations Behavioural Brain Research 256, 677 – 689 (2013)

Udvardi PT, Föhr K, Henes C, Liebau St, Dreyhaupt J, Boeckers TM, Ludolph AG Atomoxetine affects transcription/translation of the NMDAreceptor and the norepinephrine transporter in the rat brain – an in vivo study. Drug Design, Development and Therapy 7 1433–1446 (2013)

Stockmann M, Meyer-Ohlendorf M, Yin H; Hendrich C, Linta L, Proepper Ch, Kuh GF; Baumann B, Langer T, Schwalenstöcker B, Braunstein KE, von Arnim Ch, Schneuwly St, Suessmuth S, Meyer Th, Wong PC, Boeckers TM, Ludolph AC and Liebau St The Dynactin p150 Subunit: 
Clinical and cell biology studies of 4 mutations found in ALS/MND and Parkinsonian Syndromes. J Neural Transmission 120(5):785-98 (2013)

Stockmann M, Linta L, Boeckers A, Ludolph AC, Kuh GF, Udvardi P, Storch A, Kleger A, Liebau S and Boeckers TM Developmental and functional nature of human iPS derived motor neurons. Stem Cell Reviews and Reports 9(4):475-92 (2013)

Linta L, Boeckers TM, Kleger A, Liebau S. Calcium activated potassium channel expression during human iPS cell-derived neurogenesis. Ann Anat. 195(4):303-11 (2013)

Linta L, Stockmann M, Lin Q, Lechel A, Proepper C, Boeckers TM, Kleger A, Liebau S.Microarray-Based Comparisons of Ion Channel Expression Patterns: Human Keratinocytes to Reprogrammed hiPSCs to Differentiated Neuronal and Cardiac Progeny. Stem Cells Int. 784629

Mameza MG, Dvoretskova E, Bamann M., Hönck HH., Sieber S, Güler T, Boeckers TM, Schoen M, Verpelli Ch., Sala C, Barsukov I., Dityatev A and Kreienkamp HJ SHANK3 mutations associated with autism facilitate ligand binding to the Shank3 Ankyrin repeat region. JBC
13;288(37):26697-708 (2013)

Schmeisser MJ, Kühl SJ, Weis TM, Beth NH, Schoen M, Grabrucker AM, Kühl M, Boeckers TM The Nedd4 binding protein 3 (N4BP3) is crucial for the correct axonal and dendritic branching in developing neurons. 
Neural Development 17;8:18 (2013)

Weidgang C, Tata PR, Russell R, Mueller M, Bernemann C, Friedle H, Illing A, Lin Q, Kühl M, Brunner C, Boeckers TM, Seufferlein T, von Wichert G, Zenke M, Kyba M, Schöler H, Arnold SJ, Liebau S and Kleger A Tbx3 governs cell fate decision towards mesendoderm in mouse embryonic stem cells. Stem cell reports 29;1(3):248-65 (2013)


Leblond CS, Heinrich J, Delorme R, Proepper C, Betancur C,Huguet G, Konyukh M, Chaste P, Ey E, Rastam M, Anckarsäter H, Nygren G, Ståhlberg O, Gillberg IC, Melke J, Toro R, Regnault B, Fauchereau F, Mercati O, Lemière N, Skuse D, Poot M, Holt R, Curran S, Collier D, Bolton P, Chiocchetti A, Klauck SM, Poustka F, Freitag CM, Bacchelli  E, Minopoli F, Maestrini E, Mazzone L, Ruta L, Sousa I, Vicente A, Oliveira G, Pinto D, Scherer S, Zelenika D, Delepine M, Lathrop M, Guinchat V, Devillard F, Assouline B, Mouren MC, Leboyer M, Gillberg C, Boeckers TM and Bourgeron T Genetic and functional analyses of SHANK2 mutations provide evidence for a multiple hit model of autism spectrum disorders. Plos Genetics 8, 2; e1002521 (2012) (IF 9,5)

Beyer A, von Einem B, Schwanzar D, Keller I, Hellrung A, Thal D, ngelsson M, Makarova A, Deng M, Chhabra E, Pröpper Ch, Böckers TM, Hyman B, von Arnim C Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-beta precursor protein. Neurobiology of Aging, 33(4):732-43 (2012) (IF 6,2)

Linta L, Stockmann M, Boeckers TM, Kleger A and Liebau S The potential of iPS cells in synucleinopathy research. Stem Cells International ID 629230 (2012)

Schmeisser MJ, Baumann B, Johannsen S, Vindedal GM, Jensen V, Hvalby Ø, Sprengel R, Seither J, Lattke M, Oswald F, Boeckers TM and  Wirth T IKK/NF-κB signaling dynamically regulates synapse  formation and spine maturation via Igf2/Igf2R. J Neurosci 32(16):5688-5703; (2012) (IF 7,2)

Verpelli C, Schmeisser MJ, Sala C, Boeckers TM. Scaffold proteins at the postsynaptic density. Adv Exp Med Biol. 970:29-61(2012) Review.

Schmeisser MJ, Ey E, Wegener St, Kuebler A, Bockmann J, ShibanE, Spilker C, Balschun D, Skryabin BV, tom Dieck S, Smalla KH, Montag D, Leblond C, Faure P, Torquet N, Le Sourd AM, Stempel V, Shoichet S, Schmitz D, Kreutz MR, Bourgeron T, Gundelfinger ED and Boeckers TM Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature, 486: 256-260 (2012) (IF 36)

Stockmann M, Linta L, Boeckers A, Ludolph AC, Kuh GF, Udvardi P, Storch A, Kleger A, Liebau S and Boeckers TM Developmental characterization of hiPS derived motor neurons and their synaptic specialization. Stem Cell Reviews and Reports (in press) (IF 5,01)

Linta L, Stockmann M, Böckers A, Storch A, Lin Q, Boeckers TM, Kleger A and Liebau S Rat embryonic fibroblasts significantly improve reprogramming of human keratinocytes into hiPS cells. Stem Cells and Development (in press) (IF 4,7)

Müller M; Stockmann M, Malan D, Wolheim A, Tischendorf M, Linta L, Katz SF, Lin Q, Latz S; Brunner C, Wobus AM, Zenke M, Wartenberg M,Boeckers TM, von Wichert G, Fleischmann B, Liebau S and Kleger A ;Ca2+-activated K+-Channels - New Tools to induce Cardiac Commitment from Pluripotent Stem Cells in Mice and Men. Stem cell reviews and reports (in press) (IF 5,01)

Kuh GF, Stockmann M, Meyer-Ohlendorf M, Linta L, Proepper C, Ludolph AC, Bockmann J, Boeckers TM and Liebau S Tubulin binding cofactor B is a direct interaction partner of the Dynactin subunit p150glued. CTR (in press) (IF 2,8)

Heinrich J, Proepper C, Schmidt Th, Liebau St., Boeckers TM The postsynaptic density protein Abi-1 interacts with the motor protein Kif26B in hippocampal neurons. Neuroscience (in press) (IF 3,2)

Arons M, Thynne Ch, Grabrucker A, Li D, Schoen M, Cheyne J, Boeckers TM, Montgomery J and Garner C Autism associated mutations in ProSAP2/Shank3 impair synaptic transmission and neurexin-neuroligin mediated transsynaptic signaling. J Neuroscience (in press) (IF 7,2)

Schmidt-Straßburger U, Schips TG, Maier HJ, Kloiber K, Mannella F, Braunstein KE, Holzmann K, Liebau St, Boeckers TM, Wirth Th Expression of constitutively active FoxO3 in murine forebrain leads toa loss of neural progenitors FASEB J (in press) (IF 6,4)


Schaz U, Föhr, Liebau St, Fulda S, Koelsch, Fegert JM, Boeckers TM, Ludolph AG Dose dependent modulation of apoptotic processes by
Fluoxetine in maturing neuronal cells: an in vitro study. World J of Biol Psychiatry 12(2):89-98 (2011) (IF 5,5)

 A. Grabrucker, MJ Knight, Ch Proepper, J Bockmann, M Joubert, M Rowan, UG Nienhaus, C Garner, J Bowie, M R Kreutz, E. D. Gundelfinger, TM Boeckers Concerted action of Zinc and ProSAP/Shank in synaptogenesis and synapse maturation. EMBO J 30:569-581 (2011) (IF 10,1)

Grabrucker AM; Garner CC; Boeckers TM; Bondioli L; Ruozi B; Forni F; Vandelli MA; Tosi G Development of novel Zn2+ loaded
nanoparticles designed for cell-type targeted drug release in CNS neurons: in vitro evidences. Plos One 23;6(3):e17851 (2011) (IF 4,3)

Liebau S, Steinestel J, Linta L, Kleger A, Storch A, Schoen M, Steinestel K, Schmeißer MJ, Proepper Ch, Bockmann J and Boeckers TM An
SK3 channel/nWASP/Abi-1 complex is involved in early neurogenesis. Plos One 25;6(3):e18148. (2011) (IF 4,3)

Gessert S, Schmeisser MJ, Tao SJ, Boeckers TM and Kühl M The spatio-temporal expression of ProSAP/Shank family members and their interaction partner LAPSER1 during Xenopus laevis development. Dev Dyn 240, 1528-1536 (2011) (IF 2,8)

Grabrucker AM, Schmeisser MJ, Schoen M and Boeckers TM  Postsynaptic ProSAP/Shank scaffolds in the cross-hair of  synaptopathies. TCB 21;10 594-603 (2011) (IF 12,1)

Verpelli C, Dvoretskova E, Rossi F, Chiappalone M, Schoen M, Di  Stefano B, Broccoli V, Böckers TM, Dityatev A and Sala C SHANK3 has a critical role in regulating mGluR5 expression and signaling at  synapses. JBC 7; 286(40):34839-34850 (2011) (IF 5,3)

Grabrucker AM, Schmeisser MJ, Udvardi PT, Rowan M, Schoen M., Woodling NS, Hof PR, Buxbaum JD, Garner C and Boeckers TM Amyloid beta protein-induced zinc sequestration leads to a dysregulation of the postsynaptic ProSAP2/Shank3 scaffold. Mol Neurodegeneration 6:65 (2011) (IF 5,3)

Koch D, Spiwoks-Becker I, Sabanov V, Sinning A, Dugladze T,  Stellmacher A, Ahuja R, Grimm J, Schüler S, Müller A, Angenstein F, Ahmed T, Diesler A, Moser M, tom Dieck S, Spessert R, Boeckers TM, Faessler R, Hübner CA, Balschun D, Gloveli T, Kessels MM, Qualmann B Proper synaptic vesicle formation and neuronal network activity critically rely on syndapin I. EMBO J 1-15 (2011) (IF 10,1)

Proepper C, Steinestel K, Schmeisser M, Heinrich J, Langer J, Liebau S, Bockmann J and Boeckers TM Heterogenous nuclear ribonucleoprotein K (hnRNPK) binds Abi-1 at synaptic sites. Plos One 6,(11), e27045 (2011) (IF 4,3)

Liebau S, Tischendorf M, Ansorge D, Linta L, Stockmann M, Weidgang C, Iacovino M, Boeckers TM, von Wichert G, Kyba M and Kleger A; An inducible expression system of the Calcium Activated Potassium Channel 4 to study the differential impact on embryonic stem cells. Stem Cells International 2011-456815 (2011) 


Bartelt-Kirbach, B. and Golenhofen, N: Differential Expression and Induction of Small Heat Shock Proteins in Rat Brain and Cultured Hippocampal Neurons. J Neurosci Res 89: 162-175 (2011), published online 8 Dec 2010.

Habisch HJ, Liebau S, Lenk T, Ludolph AC, Brenner R, Storch A. Neuroectodermally converted human mesenchymal stromal cells provide cytoprotective effects on neural stem cells and inhibit their glial differentiation. Cytotherapy. 2010;12:491-504

Kleger A, Seufferlein T, Malan D, Tischendorf M, Storch A, Wolheim A, Latz S, Protze S, Porzner M, Proepper C, Brunner C, Katz SF, Pusapati GV, Bullinger L, Franz WM, Koehntop R, Giehl K, Spyrantis A, Wittekindt O, Lin Q, Zenke M, Fleischmann BK, Wartenberg M, Wobus AM, Boeckers TM, Liebau S. Modulation of calcium-activated potassium channels induces cardiogenesis of pluripotent stem cells and enrichment of pacemaker-like cells. Circulation. 2010;122:1823-1836

Maisel M, Habisch HJ, Royer L, Herr A, Milosevic J, Hermann A, Liebau S, Brenner R, Schwarz J, Schroeder M, Storch A. Genome-wide expression profiling and functional network analysis upon neuroectodermal conversion of human mesenchymal stem cells suggest hif-1 and mir-124a as important regulators. Exp Cell Res. 2010;316:2760-2778

Schaz U, Fohr KJ, Liebau S, Fulda S, Koelch M, Fegert JM, Boeckers TM, Ludolph AG. Dose-dependent modulation of apoptotic processes by fluoxetine in maturing neuronal cells: An in vitro study. World J Biol Psychiatry. 2010

Steinacker P, Hawlik A, Lehnert St, Jahn O, Meier St, Görz E, Braunstein K, Krzovska M, Schwalenstöcker B, Jesse S, Pröpper Ch, Böckers TM, Ludolph A and Otto M Neuroprotective function of cellular prion protein in a mouse model of amyotrophic lateral sclerosis. American Journal of Pathology 176 (3):1409-1420 (2010) (IF 5,3)

Ludolph A., Udvardi P., Schaz U., Henes C., Adolph O., Weight HU., Fegert J., Boeckers T.M., Foehr KJ Atomoxetine acts as a NMDA receptor blocker in clinically relevant concentrations. British J of Pharmacology 160(2):283-91(2010) (IF 4,9)

Beyer A, von Einem B, Schwanzar D, Keller I, Hellrung A, Thal D, Ingelsson M, Makarova A, Deng M, Chhabra E, Pröpper Ch, Böckers TM, Hyman B, von Arnim C Engulfment adapter PTB domain containing 1 interacts with and affects processing of the amyloid-beta precursor protein. Neurobiology of Aging (in press) (IF 6,2)

Raab M, Boeckers TM, Neuhuber WL. Proline-rich synapse-associated protein-1 and 2 (ProSAP1/Shank2 and ProSAP2/Shank3)-scaffolding proteins are also present in postsynaptic specializations of the peripheral nervous system. Neuroscience 1;171(2):421-33 (2010) (IF 3,8)

Böckers A, Jerg-Bretzke L, Lamp Ch, Brinkmann A, Traue HC, Böckers TM The gross anatomy course: An analysis of its importance. Anat Sci Educ. 3(1):3-11 (2010)

A Boryor, A Hohmann, A Wunderlich, M. Geiger, F Kilic, M Sander, C Sander, T. Böckers, FG Sander In vitro results of rapid maxillary expansion of adults compared wirth finite elements simulations. J Biomech. 7;43(7):1237-42 (2010)

A Boeckers, A Brinkmann, L Jerg-Bretzke, TM Boeckers, HC Traue How can we deal with mental distress in the dissection room? - An evaluation of the need of psychological support. Ann Anat. 2010 Dec 20;192(6):366-72


Haug C, Haug J. T., Waloszek D, Maas A, Frattigiani R, Liebau S, New Methods to document Fossils from Lithographic Limestones of southern Germany and Lebanon. Palaeontologia Electronica Vol 12, Issue 3; 6T:12p

Schmeisser M, Unrath A, Otto, M, Tumani H, Alber B; Moyamoya Diseae Precipitating Sydenham´s Chorea in a 19-Year-Old Caucasian Woman. Movement Disorders Vol 24 No 9 (2009) pp 1402-1403

Sawallisch C, Berhörster K, Disanza A, Mantoani S, Kintscher M, Stoenica L, Dityatev A, Sieber S, Kindler St, Morellini F, Schweizer M, Boeckers TM, Korte M, Scita G and Kreienkamp HJ The insulin receptor substrate of 53 kDa (IRSp53) limits hippocampalsynaptic plasticity. J Biol Chem. 3;284(14):9225-36 (2009)

St Liebau, C Proepper, M Schoen, Th Schmidt, J Bockmann and TM Boeckers ProSAPiP2, a novel postsynaptic density protein that interacts with ProSAP2/Shank3. BBRC 385: 460-465 (2009) AM

Grabrucker, B Vaida, J Bockmann and TM Boeckers Efficient targeting of proteins to postsynaptic densities of excitatory synapses using a novel pSDTarget vector system. J. Neurosci Methods 181;227-234 (2009)

Vellanki SH, Grabrucker AM, Liebau S, Proepper C, Eramo A, Braun V, Boeckers TM De Maria R, Debatin KM Fulda S. Small molecule XIAP inhibitors enhance γ-irradiation induced apoptosis in preclinical models of glioblastoma. Neoplasia ;11(8):743-52 (2009)

MJ Schmeisser, AM Grabrucker, J Bockmann, TM Boeckers Synaptic crosstalk between NMDA receptors and LAPSER1/β-catenin at excitatory synapses. J Biol Chem. 16;284(42):29146-57 (2009)

A Grabrucker, B Vaida, J Bockmann and TM Boeckers Synaptogenesis of hippocampal neurons in primary cell culture. CTR 338(3):333-341 (2009)


Dieterich D, Karpova A, Mikhaylova M., Zdobnova I., König I., Landwehr M., Kreutz M., Smalla K-H., Richter K., Landgraf P, Reissner C., Boeckers TM, Zuschratter W., Spilker C., Seidenbecher C., Garner CC., Gundelfinger ED, Kreutz MR Caldendrin-Jacob: a protein liaison that couples NMDA receptor signalling to the nucleus. PloS Biology 6(2) e34 (2008)

Spilker Ch., Samorano P., Boeckers TM, Kreutz MR, Gundelfinger ED SPAR2, a novel SPAR-related protein with GAP activity for Rap1 and Rap2. J Neurochem 104, 187-201 (2008)

Johannsen S, Duning K, Pavenstädt H-J, Kremerskothen J, Boeckers TM Temporal-spatial expression and novel biochemical properties of the memory-related protein KIBRA. Neuroscience 155, 1165-1173 (2008)


Liebau St, Vaida B, Storch A, Boeckers TM Maturation of synaptic contacts in differentiating neural stem cells (NSCs). Stem Cells 25, 1720-1729 (2007)

Durand CM, Betancur C, Boeckers TM, Bockmann J, Chaste P, Fauchereau F, Nygren G, Rastam M, Anckarsäter H, Sponheim E, Goubran-Botros H, Delorme R, Chabane N, Mouren-Simeoni MC, Bieth E, Rogé B, Héron D, Burglen L, Gillberg Ch, Leboyer M, Bourgeron Th Mutations of the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nature Genetics 39(1):25-27 (2007)

Redecker P., Bockmann J., Boeckers TM Secretory granules of hypophyseal and pancreatic endocrine cells contain proteins of the neuronal postsynaptic density.
Cell Tissue Res 328(1): 49-55 (2007)

Liebau St, Vaida B, Grissmer St, Storch A, Boeckers TM, Dietl P, Wittekindt OH Filopodial sprouting and elongation in neural progenitor cells is modulated by the calcium activated potassium channel, SK3. J Neurochem. 101(5):138-150 (2007)

Proepper Ch, Johannsen S., Liebau St., Bockmann J., Vaida B., Kreutz MR., Gundelfinger ED, Boechers TM, Abi-1, a PSD and nuclear protein, is essential for regulated dendrite morphogenesis and synapse formation. EMBO J 7;26 (5):1397-1409 (2007)


Teuchert M, Fischer D, Schwalenstoecker B, Habisch HJ, Boeckers TM, Ehret G, Ludolph AC A dynein mutation attenuates motor neuron degeneration in SOD1(G93A) mice. Exp Neurology 198:271-274 (2006)

Baron MK, Boeckers TM, Vaida B, Faham S, Gingery M, Sawaya M, Salyer D, Gundelfinger ED, Bowie JU An architectural framework that may lie at the core of the post-synaptic density. Science 311, 531-535 (2006)

Wendholt D, Spilker C, Schmitt A, Dolnik A, Smalla KH, Proepper Ch, Bockmann J, Sobue K, Gundelfinger ED, Kreutz MR, Boeckers TM ProSAP interacting protein1 (ProSAPiP1), a novel postsynaptic density protein that links the spine associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2 / Shank3. J Biol Chem 12; 281(19):13805-13816 (2006)

Gundelfinger ED, Boeckers TM, Baron M, Bowie JU A role for zinc in synapse asSAMbly and plasticity? TIBS 31(7):366-373 (2006)

Tsuriel S., Geva R., Zamorano P, Dresbach Th, Boeckers TM, Gundelfinger ED, Garner CC and Ziv NE Local Sharing as a Predominant Determinant of Synaptic Matrix Molecular Dynamics. PloS Biology 15;4(9) (2006)

Swan LE, Schmidt M, Schwarz T., Ponimaskin E, Prange U, Boeckers TM, Thomas U, Sigrist St. Echinoid and Drosophila GRIP organize Drosophila muscle guidance via a complex interaction. EMBO J 9;25(15):3640-51 (2006)


Boeckers TM The postsynaptic density. Cell Tissue Res, 326(2):409-422 (2006)


Liebau St, Proepper Ch., Boeckers TM, Lehmann-Horn F, Storch A, Grissmer St, Wittekind OH Selective blockage of Kv1.3 and Kv3.1 channels increases neural progenitor cells proliferation. J Neurochem 99(2):426-437 (2006)

Ludolph AG, Schaz U, Storch A, Liebau St, Fegert JM, Boeckers TM Methylphenidate exerts no neurotoxic, but neuroprotective effects in vitro. J Neural Transmission 113(12):1927-1934 (2006)

Redecker P., Bockmann J., Boeckers TM Expression of postsynaptic density proteins of the ProSAP/Shank family in the thymus. Histochem and Cell Biology 126(6):679-685 (2006)

Rostaing, P., E. Real, L. Siksou, J.-P. Lechaire, T. Boudier, TM Boeckers, F. Gertler, E.D. Gundelfinger, A. Triller and S. Marty. Analysis of synaptic ultrastructure without fixative using high pressure freezing and tomography. Eur. J. Neurosci. 24; 3463-3474 (2006)


Boeckers TM, Liedtke Th, Dresbach Th, Bockmann J, Kreutz MR, Gundelfinger ED C-terminal synaptic targeting elements for postsynaptic density proteins ProSAP1/Shank2 and ProSAP2/Shank3. J Neurochem. 92(3) 519-524 (2005)


Schütz G, Rosário M, Grimm J, Boeckers TM, Gundelfinger ED, Birchmeier W
The neuronal scaffold protein, Shank3, mediates signalling and biological function of the receptor tyrosine kinase Ret in epithelial cells.
J. Cell. Biol. 167:945-952 (2004)

Brandstätter JH, Dick O., Boeckers TM
The Postsynaptic Scaffold Proteins ProSAP1/Shank2 and Homer1 are Associated with NMDA and Group I Metabotropic Glutamate Receptor Complexes at Retinal Synapses
JCN 475:551-563 (2004)

Kindler St., Rehbein M., Classen B., Richter D., Böckers TM
Distinct spatiotemporal expression of SAPAP transcripts in the developing rat brain: a novel dendritically localized mRNA.
Molec Brain Research 126, 14-21(2004)

Böckers TM, Segger-Junius M., Iglauer P., Bockmann J, Gundelfinger ED, Kreutz MR, Richter D., Kindler S., Kreienkamp HJ.
Differential expression and dendritic transcript localization of all three ProSAP/SSTRIP/Shank family members: Identification of a dendritic targeting element in the 3' untranslated region of Shank1 mRNA.
MCN 26, 182-190 (2004)

CI Seidenbecher, M Landwehr, K-H Smalla, M Kreutz, DC Dieterich, W Zuschratter, C Reissner, J A Hammarback, T M Böckers, E D Gundelfinger, M R Kreutz
Caldendrin but not Calmodulin Binds to Light Chain 3 of MAP1A/B – An Association with the Microtubule Cytoskeleton highlighting exclusive Binding Partners for Neuronal
Ca2+-Sensor Proteins.
J Molec Biology 27; 336:957-70 (2004)

Qualmann B, Boeckers T.M., Jeromin M, Gundelfinger ED, Kessels M
Linkage of the actin cytoskeleton to the postsynaptic density via direct interactions of Abp1 with the ProSAP/Shank family
J. Neurosci 24: 2481-2495 (2004)

T. Bresler, M. Shapira, T. Boeckers, Th. Dresbach, M. Futter, C. C. Garner, K. Rosenblum, E. D. Gundelfinger, N. E. Ziv
Post Synaptic Density Assembly is Fundamentally Different from Presynaptic Active Zone Assembly.
J. Neurosci 24(6):1507-20 (2004)

Kreutz MR, Weise J, Dieterich DC, Kreutz M, Balczarek P, Bockers TM, Wittkowski W, Gundelfinger ED, Sabel BA.
Rearrangement of the retino-collicular projection after partial optic nerve crush in the adult rat.
Europ. J. Neurosci. 19(2):247-57 (2004)


MR Kreutz K.-H. Smalla, C. Seidenbecher, W. Tischmeyer, Ho. Schicknick, U. Wyneken, T. Boeckers, E. Gundelfinger
Kainate-induced epileptic seizures induce a recruitment of caldendrin to the postsynaptic density in rat brain.
Brain Res Mol Brain Res 19;116:159-62 (2003)

Landwehr M, Redecker P, Dieterich DC, Richter K, Bockers TM, Gundelfinger ED, Kreutz MR. Association of Caldendrin splice isoforms with secretory vesicles in neurohypophyseal axons and the pituitary.
FEBS Lett. 17;547(1-3):189-92 (2003)

Dieterich DC, Landwehr M, Reissner C, Smalla K-H, Richter K, Wolf G, Böckers TM, Gundelfinger ED, Kreutz MR
Gliap- A novel untypical L-asparaginase localized to rat brain astrocytes.
J Neurochem 85(5):1117-25 (2003)

Smalla KH, Seidenbecher CI, Tischmeyer W, Schicknick H, Wyneken U, Bockers TM, Gundelfinger ED, Kreutz MR.
Kainate-induced epileptic seizures induce a recruitment of caldendrin to the postsynaptic density in rat brain.
Brain Res Mol Brain Res. 116:159-62 (2003)

Floris G. Wouterlood, Tobias Böckers, Menno P. Witter
Synaptic contacts between identified neurons visualized in the confocal laserscanning microscope. Neuroanatomical tracing combined with immunofluorescence detection of postsynaptic density proteins and target neuron-markers.
J Neurosc Meth 128:129-142 (2003)

H. Marzaban, U. Khandaza, S. Shabir, R. Hawkes, K. Langnaese, K.-H Smalla, T.M. Boeckers, E.D. Gundelfinger, P.R. Gordon-Weeks, P.W. Beesly
Expression of the immunoglobin superfamily neuroplastin adhesion molecules in adult and developing mouse cerebellum and their localization to parasagittal stripes.
J Comp Neurol 462:286-302 (2003)

Redecker P, Kreutz MR, Bockmann J, Gundelfinger ED, Boeckers TM
Brain Synaptic Junctional Proteins at the Acrosome of Rat Testicular Germ Cells.
Histochem Cytochem 51:809-819 (2003)

Altrock WD, tom Dieck S, Sokolov M, Meyer AC, Sigler A, Brakebusch C, Fässler R, Richter K, Boeckers TM, Potschka H, Brandt C, Löscher W, Grimber D, Dresbach T, Hempelmann A, Hassan H, Balschun D, Frey JU, Brandstätter JH, Garner CC, Rosenmund C, Gundelfinger ED
Functional inactivation of excitatory glutamatergic synapses in mice deficient for the active zone protein Bassoon.
Neuron 37, 787-800 (2003)


Bockmann J, Kreutz MR, Gundelfinger ED, Böckers TM
ProSAP / Shank postsynaptic density proteins interact with insulin receptor tyrosine kinase substrate IRSp53.
J Neurochem 83, 1013-1017 (2002)

Brakebusch C, Seidenbecher CI, Asztely F, Rauch U, Matthies H, Meyer H, Krug M, Böckers TM, Zhou X, Kreutz MR, Montag D, Gundelfinger ED, Fässler R
Brevican-deficiant mice display impaired hippocampal CA1 long term potentiation but show no obvious deficits in learning and memory.
Mol Cell Biol 22, 7417-7427 (2002)

Kremerskothen J, Teber I, Wendholt D, Liedtke T, Böckers TM, Barnekow A
Brain-specific splicing of α-actin1 (ACTN1) mRNA.
Biochem Biophys Res Commun 19, 678-81 (2002)

Kreienkamp HJ, Soltau M, Richter D, Bockers T
Interaction of G-protein-coupled receptors with synaptic scaffolding proteins.
Biochem Soc Trans 30464-8; (2002)

Butterweck V, Boeckers TM, Korte B, Wittkowski W, Winterhoff H
Long-term effects of St. John’s wort and hypericin on monoamine levels in rat hypothalamus and hippocampus.
Brain Res 930:21-9 (2002)

Laube G, Seidenbecher CI, Richter K, Dieterich DC, Hoffmann B, Landwehr M, Smalla KH, Winter C, Böckers TM, Wolf G, Gundelfinger ED, Kreutz MR
The neuron-specific Ca2+-binding protein caldendrin: gene structure, splice isoforms and expression in the rat central nervous system.
Mol Cell Neurosci 19:459-75 (2002)

Dieterich DC, Böckers TM, Gundelfinger ED, Kreutz MR
Screening for differentially expressed genes in the inner retina and optic nerve after optic nerve crush.
Neurosci Lett 317:29-32 (2002)

Böckers TM, Bockmann J, Kreutz MR, Gundelfinger ED
ProSAP/Shank proteins– a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease.
J Neurochem 81(5): 903910 (2002)


Böckers TM, Mameza MG, Kreutz MR, Bockmann J, Weise C, Buck F, Richter D, Gundelfinger ED, Kreienkamp H-J
Synaptic scaffolding proteins in rat brain: Ankyrin repeats of the multidomain Shank protein family interact with the cytoskeletal protein α-fodrin.
J Biol Chem 276(43):40104-40112 (2001)

Helmuth M, Altrock W, Böckers TM, Gundelfinger ED, Kreutz MR
An electrotransfection method for yeast-two-hybrid screening.
Anal Biochem 1;293(1):149-152 (2001)

Zhou X-H, Brakebusch C, Matthies H, Oohashi T, Hirsch E, Moser M, Krug M, Seidenbecher CI, Boeckers TM, Gundelfinger ED, Rauch U, Buettner R, Fässler R
Neurocan is dispensable for brain development.
Mol Cell Biol 21(17):5970-8 (2001)

Redecker P, Gundelfinger ED, Boeckers TM
The cortactin-binding postsynaptic density protein ProSAP1 in non-neuronal cells.
Histochem Cytochem 49(5):639-48 (2001)

Bock N, Böckers TM, Bockmann J, Nowak P, Buse E, Wittkowski W
The pars tuberalis of the monkey (Macaca fascicularis) hypophysis: Cell types and hormone expression.
Cells Tiss Org 169(1):55-63 (2001)

Wyneken U, Smalla KH, Marengo JJ, Soto D, de la Cerda A, Tischmeyer W, Grimm R, Boeckers TM, Wolf G, Orrego F, Gundelfinger ED
Kainate-induced seizures alter protein composition and NMDA receptor function of rat forebrain postsynaptic densities.
Neurosciences, 102:65-74 (2001)

Bockmann J, Böckers TM, Kreutz MR, Wittkowski W
The pars tuberalis of the pituitary: New results, new questions.
Rec Res Develop Endocrinol, Vol1 part 1 247-260 (2001)


Kreienkamp H-J, Zitzer H, Gundelfinger ED, Richter D, Böckers TM
The calcium independent receptor for α-latrotoxin from human and rodent brain interacts with members of the ProSAP/SSTRIP/Shank family of multidomain proteins.
J Biol Chem 275,32387-32390 (2000)

Smalla KH, Matthies H, Langnaese K, Shabir S, Böckers TM, Wyneken U, Staak S, Krug M, Beesley PW, Gundelfinger ED
The synaptic glycoprotein neuroplastin is involved in long-term potentiation at hippocampal CA1 synapses.
Proc Natl Acad Sci (USA) 97(8) 4327-4332 (2000)


Böckers TM, Winter C., Smalla KH, Kreutz MR, Bockmann J, Seidenbecher C., Garner CC, Gundelfinger ED
Proline Rich Synapse Associated Proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family.
Biochem Bioph Res Com 14;264(1)247-252(1999)

Vorwerk CK, Kreutz MR, Böckers TM, Brosz M, Sabel BA
Retinal ganglion cell susceptibility to NMDA and kainate excitotoxicity depends on soma size and eccentric location.
Curr Eye Res 19(1):59-65 (1999)

Böckers TM, Kreutz MR, Winter C, Smalla KH, Zuschratter W, Wex H, Langnäse K, Sanmarti-Vila L, Bockmann J, Garner CC, Gundelfinger ED
Proline Rich Synapse Associated Protein1/ Cortactin Binding Protein 1 (ProSAP1/CortBP1) is highly enriched in the postsynaptic density (PSD).
J Neuroscience 19(15): 6506-6518 (1999)

Winter C, tom Dieck S, Böckers TM, Bockmann J, Kämpf U, Sanmarti-Vila L, Langnaese K, Altrock W, Stumm M, Soyke A, Wieacker P, Garner CC, Gundelfinger ED
The presynaptic cytomatrix protein Bassoon: Sequence and chromosomal localization of the human BSN gene.
Genomics 57, 389-397 (1999)

Kreutz MR, Bien A, Böckers TM, Seidenbecher C, Vorwerk CK, Tischmeyer W, Sabel BA
Co-expression of c-jun and ATF-2 characterizes the surviving retinal ganglion cells which maintain axonal connections after partial optic nerve injury.
Mol Brain Res 69,232-241 (1999)

Bien A, Seidenbecher C, Böckers TM, Sabel BA, Kreutz MR
Apoptotic versus necrotic characteristics of retinal ganglion cell death after partial optic nerve injury.
J Neurotrauma 16 (2); 153-163 (1999)

Wittkowski W, Bockmann J, Kreutz MR, Böckers TM
Cell and molecular biology of the pars tuberalis of the pituitary.
Int Rev Cytol 185: 157-194 (1999)


Jacobs S, Schürmann A, Becker W, Böckers TM, Jenkins N, Joost H-G
The mouse ADP-ribosylation factor-like protein 4 (arl4) gene: Two separate promoters direct specific transcription in tissues and post-meiotic spermatides.
Biochem J 335:259-265 (1998)

Kreutz MR, Böckers TM, Bockmann J, Seidenbecher C, Vorwerk CK, Weise J, Sabel BA
Axonal injury alters alternative splicing of the retinal NR1 receptor: The preferential expression of the NR1-b isoforms is crucial for retinal ganglial cell survival.
J Neuroscience 18(20):8278-8291 (1998)

Seidenbecher C, Langnäse K, Sanmarti Vila L, Böckers TM, Sabel B, Gundelfinger E, Kreutz MR
Caldendrin, a novel neuronal Calcium binding protein confined to the somato-dendritic compartment.
J Biol Chem 273 (33); 21324-21331 (1998)

Bockmann J, Winter C, Kreutz M, Wittkowski W, Böckers TM
A PCR strategy for screening DNA libraries.
Technical Tips Online (TTO) formerly: Trends in Genetics ( to1373 (1998)

Seidenbecher C, Gundelfinger E, Böckers TM, Kreutz MR
Transcripts for secreted and GPI-anchored brevican are differentially distributed in rat brain.
Eur J Neurosci 10:1621-1630 (1998)


Bockmann J, Wittkowski W, Kreutz MR, Böckers TM
TSH expression in murine hypophyseal pars tuberalis-specific cells.
Acta Anat 160: 189-194 (1997)

Kreutz MR, Böckers TM, Sabel BA, Hülser E, Stricker R, Reiser G
Expression and subcellular localization of a p42IP4/Centaurin- α; a-brain specific, high-affinity receptor for inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-triphosphate in rat brain.
Eur J Neurosci 9:2110-2124 (1997)

Bockmann J, Winter C, Kreutz MR, Wittkowski W, Böckers TM
Cloning and expression of a brain-derived TSH receptor.
Biochem Bioph Res Com 238:173-178 (1997)

Böckers TM, Bockmann J, Salem A, Niklowitz P, Lerchl A, Huppertz M, Wittkowski W, Kreutz MR
Initial expression of the common α-chain in pars tuberalis-specific cells in spontaneous recrudescence.
Endocrinology 138: 4101-4108 (1997)

Kreutz MR, Böckers TM, Hülser E, Sabel BA, Reiser G
Localization of a 42-kDA inositol 1,3,4,5-tetrakisphosphate receptor protein in retina and change in expression after optic nerve injury.
Mol Brain Res 45:283-293 (1997)

Bockmann J, Böckers TM, Winter C, Wittkowski W, Winterhoff H, Deufel Th, Kreutz MR
Thyrotropin expression in hypophyseal pars tuberalis-specific cells is 3,5,3´-triiodothyronine, thyrotropin-releasing hormone, and Pit-1 independent.
Endocrinology 138: 1019-1028 (1997)


Niklowitz P, Böckers TM, Lerchl A
Afternoon injections of melatonin in the Djungarian hamster Phodopus sungorus: Long lasting sex-specific effects and influence of acute treatment on the endogenous pineal melatonin rhythm.
J Pineal Res 21:231-238 (1996)

Bockmann J, Böckers TM, Vennemann B, Niklowitz P, Müller J, Wittkowski W, Sabel B, Kreutz MR
Short photoperiod-dependent downregulation of α- and β- TSH in hamster pars tuberalis-specific cells is prevented by pinealectomy.
Endocrinology 137:1804-1813 (1996)

Böckers TM, Bockmann J, Fauteck J-D, Wittkowski W, Sabel B, Kreutz MR
Evidence for gene transcription of adenohypophyseal hormones in the ovine pars tuberalis.
Neuroendocrinology 63:16-27 (1996)


Fauteck J-D, Bockmann J, Böckers TM, Wittkowski W, Köhling R, Lücke A, Straub H, Speckmann E-J, Noachtar S, Tuxhorn I, Wolf P, Pannek H, Oppel F
Melatonin reduces low Mg2+ epileptiform activity in human temporal slices.
Exp Brain Res 107:321-325 (1995)

Böckers TM, Niklowitz P, Bockmann J, Fauteck J-D, Wittkowski W, Kreutz MR
Daily melatonin injections induce morphological changes in pars tuberalis-specific cells similar to short photoperiod.
J Neuroendocrinol 7:607-613 (1995)

Wittkowski W, Bockmann J, Böckers TM, Fauteck J-D, Kreutz MR
"Zeitgeber" of the endocrine system. Pineal melatonin and pars tuberalis of the hypophysis.
Neurol, Psych and Brain Res 3:1-10 (1995)

Böckers TM, Kreutz MR, Pohl T
Glutaminyl-cyclase expression in bovine/porcine hypothalamus and pituitary.
J Neuroendocrinol 7:445-453 (1995)


Böckers TM, Bockmann J, Fauteck J-D, Kreutz MR, Bock R, Wittkowski W
Pars tuberalis-specific cells in the ovine pituitary do express the common alpha-chain of glycoprotein hormones: An in situ hybridization and immunocytochemical study.
Eur J Endocrinol 131:540-546 (1994)

Böckers TM, Nieschlag E, Kreutz MR, Bergmann M
Localization of follicle-stimulating hormone (FSH) immunoreactivity and hormone receptor mRNA
in testicular tissue of infertile men.
Cell Tissue Res 278:595-600 (1994)

Böckers TM, Zimmer M, Brose N, Müller A, Bergmann M, Kreutz MR
Expression of the NMDA R1-receptor in selected human brain regions.
NeuroReport 5: 965-969 (1994)


Holbeck A, Böckers TM, Sourgens H, Wittkowski W
Ultrastructure of fetal pars tuberalis specific cells under the influence of propylthiouracil and thyroxine administered maternally.
Acta Anat 147:64-68 (1993)


Wittkowski W, Schulze-Bonhage A, Böckers TM
The pars tuberalis of the hypophysis: A modulator of the pars distalis?
Acta Endocrinol 126:285-290 (1992)

Rehmert N, Böckers TM, Langer K, Raidt H, Graefe U
A new central supply system as an alternative source for bicarbonate dialysate.
Int J Artif Organs 15(4):287-290 (1992)

Del Beccaro M, Champoux A, Böckers T, Mendelman PM
Septic Arthritis versus transient synovitis of the hip: The value of screening laboratory tests.
Ann Emerg Med 21(12):14-18 (1992)


Böckers TM, Sourgens H, Jekat A, Wittkowski W
Changes in the TSH-like immunoreactivity of the fetal rat pars tuberalis after maternal administration of propylthiouracil and thyroxine.
Cell Tissue Res 260:403-408 (1990)