B05 – Identification and mechanism of human peptides protecting against therapy-induced leukemia (Lisa Wiesmüller, Christof Gebhardt)

Induction of secondary leukemias by chemotherapy-based cancer treatment represents a serious side effect that frequently involves endonuclease G (EndoG)-mediated chromosomal rearrangements at the mixed-lineage leukemia (MLL) gene. The applicants identified peptides antagonizing such rearrangements and found that they differentially affect MLL binding of EndoG, which operates in mitochondria in unstressed cells. In the 2nd funding period, they will characterize differences in peptide mode-of-action on nuclear and mitochondrial genomes and consider organelle-specific therapeutic applications. Other goals are to understand structure-based traits facilitating EndoG interactions with MLL and the effects of peptides on fragile sites other than MLL.

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Principal Investigators

Gebhardt, Christof, Prof. Dr.

Institute of Biophysics
Ulm University
Albert-Einstein-Allee 11
89081 Ulm
Tel: 0731 5023364

Wiesmüller, Lisa, Prof. Dr.

Department of Obstetrics and Gynecology
Ulm University
Prittwitzstrasse 43
89075 Ulm
Tel: 0731 50058800