C02 – Biohybrid transporters for cell type-specific delivery and controlled release of pharmacologically active peptides (Holger Barth, Jens Michaelis)

This project will develop modular hybrid transporter molecules for the efficient, cell type-specific delivery and controlled release of bioactive peptides. To achieve this, non-toxic entities of bacterial AB-toxins and synthetic dendrimers will be assembled into hybrid transporters by a “LEGO”-like building brick approach. The toxin part mediates cell-targeting by specific receptor recognition and the dendrimer allows efficient loading and controlled cytosolic release of cargo peptides. The techniques will be applied to antimicrobial and anticancer peptides examined within this CRC but are of general interest for potent and specific peptide delivery.

 

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Principal Investigators

Barth, Holger, Prof. Dr.

Institute of Pharmacology and Toxicology
Ulm University Medical Center
Albert-Einstein-Allee 11
89081 Ulm
Tel: 0731 50065503
holger.barth(at)uni-ulm.de

Michaelis, Jens, Prof. Dr.

Institute of Biophysics
Ulm University
Albert-Einstein-Allee 11
89081 Ulm
Tel: 0731 5023050
jens.michaelis(at)uni-ulm.de