C02 – Biohybrid transporters for cell type-specific delivery and controlled release of pharmacologically active peptides (Holger Barth, Jens Michaelis)

This project will develop transporter molecules for efficient delivery of bioactive peptides into specific target cell types or across the blood-brain-barrier. To achieve this, non-toxic mutants of bacterial AB-type protein toxins will be generated and used that mediate cell-targeting by specific receptor-binding subunits and controlled release of the cargo peptides into the cytosol by specific translocation subunits. These processes will be analyzed in living cells by state-of-the-art imaging methods developed in this project such as lattice light sheet microscopy and single molecule tracking. The techniques will be applied to antimicrobial and anticancer peptides which were examined within this CRC but are of general interest for potent and specific delivery.


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Principal Investigators

Barth, Holger, Prof. Dr.

Institute of Pharmacology and Toxicology
Ulm University Medical Center
Albert-Einstein-Allee 11
89081 Ulm
Tel: 0731 50065503

Michaelis, Jens, Prof. Dr.

Institute of Biophysics
Ulm University
Albert-Einstein-Allee 11
89081 Ulm
Tel: 0731 5023050