Barth, Holger, Prof. Dr.
Institute of Pharmacology and Toxicology
Ulm University Medical Center
Tel: 0731 50065503
The project will design smart therapeutic peptide nanocarriers and validate them for multimodal treatment of the tumor microenvironment in breast cancer (BC) bone metastasis. Modulating the bone microenvironment will be achieved by combined delivery of Rho-inhibiting bacterial C3 protein toxin modulating osteoclasts with EPI-X4 peptides as well as antimicrobial peptides inducing anticancer effects. A three-dimensional tumor spheroid model consisting of metastatic BC cells and osteoclasts will be used to characterize stability and release of the peptides and peptide nanocarriers and to understand their impact on cellular interactions. The multi-cargo delivery and controlled release technologies will be validated and distributed to other CRC projects.