Lindén, Mika, Prof. Dr.
Institute of Inorganic Chemistry II
Tel: 0731 5022730
Mesoporous silica particles (MSNs) represent a versatile category of nanocarriers for peptide delivery. They shield peptides against proteolytic degradation and can be functionalized for cell type- or organ-specific targeting. Furthermore, MSNs can be linked to imaging moieties, such as fluorescence markers, for convenient in vivo monitoring. The present project will thus exploit MSNs to improve the delivery, stability, specificity and release of antimicrobial and anticancer peptides and to introduce labels to monitor their biodistribution in organisms.