* equally contributing authors / shared corresponding authors

Sönmez A, Mustafa R, Ryll ST, Tuorto F, Wacheul L, Ponti D, Litke C, Hering T,  Kojer K, Koch J, Pitzer C, Kirsch J, Neueder A, Kreiner G, Lafontaine DLJ, Orth M, Liss B, Parlato R (2021): Nucleolar stress controls mutant Huntingtin toxicity and monitors Huntington’s disease progression; Cell Death and Disease; PDF

Strahnen D, Kapanaiah S, Bygrave A, Liss B, Bannerman D, Akam T, Grewe B, Johnson E, Kätzel D (2021): Highly task-specific and distributed neural connectivity in working memory revealed by single-trial decoding in mice and humans; bioRxiv preprint; doi: 10.1101/2021.04.20.440621. 

Siller A, Hofer NT, Tomagra G, Wiederspohn N, Hess S, Benkert J, Gaifullina A, Spaich D, Duda J, Pötschke C, Vilusic K, Fritz EM, Schneider T, Kloppenburg P, Liss B, Carabelli V, Carbone E, Ortner NJ, Striessning J (2021): Alternative splicing of auxiliary β2-subunits stabilizes Cav2.3 Ca2+ channel activity in continuously active midbrain dopamine neurons, bioRxiv pre-reviewed; doi: 0.1101/2021.02.10.430224. 

Mustafa R, Rawas C, Mannal N, Kreiner G,  Spittau B, Kaminska K, Yilmaz R, Pötschke C, Kirsch J, Liss B, Tucker KL, Parlato R (2021). Targeted Ablation of Primary Cilia in Differentiated Dopaminergic Neurons Reduces Striatal Dopamine and Responsiveness to Metabolic Stress,  Antioxidants 2021, 10, 1284; doi:10.3390/antiox10081284. PDF

van der Veen B, Kapanaiah S, Kilonzo K, Steele-Perkins P, Jendryka M, Schulz S, Tasic B, Yao Z, Zeng H, Akam T, Nicholson J, Liss B, Nissen W,  Pekcec A, Kätzel D (2021): Control of impulsivity by Gi-protein signalling in layer-5 pyramidal neurons of the anterior cingulate cortex, Communications Biology 4:662; doi: 10.1038/s42003-021-02188-w. PDF

Kilonzo K, van der Veen B, Teutsch J, Schulz S, Kapanaiah S, Liss B, Kätzel D (2021): Delayed-matching-to-position working memory in mice relies on NMDA-receptors in prefrontal pyramidal cells, Scientific Reports, 11:8788; doi:10.1038/s41598. PDF 

Mannal N, Kleiner K, Fauler M, Dougalis A, Poetschke C and Liss B (2021): Multi-Electrode Array Analysis Identifies Complex Dopamine Responses and Glucose Sensing Properties of Substantia Nigra Neurons in Mouse Brain Slices. Front. Synaptic Neurosci. 13:635050; doi: 10.3389/fnsyn.2021.635050. PDF

Kiechle M, von Einem B, Höfs L, Voehringer P, Grozdanov V, Markx D, Parlato R, Wiesner D, Mayer B, Sakk O, Baumann B, Lukassen S, Liss B, Ekici AB, Ludolph AC, Walther P, Ferger B, McLean PJ, Falkenburger BH, Weishaupt JH and Danzer KM (2019): In Vivo Protein Complementation Demonstrates Presynaptic a-Synuclein Oligomerization and Age-Dependent Accumulation of 8–16-mer Oligomer Species. Cell Rep 29, 2862–2874; doi: 10.1016/j.cellrep.2019.10.089. PDF

Simons C*, Benkert J*, Deuter N, Poetschke C, Pongs O, Schneider T, Duda J and Liss B (2019): NCS-1 Deficiency Affects mRNA Levels of Genes Involved in Regulation of ATP Synthesis and Mitochondrial Stress in Highly Vulnerable Substantia nigra Dopaminergic Neurons. Front. Mol. Neurosci 12:252; doi: 10.3389/fnmol.2019.00252. PDF

Benkert J, Hess S, Roy S, Beccano-Kelly D, Wiederspohn N, Duda J, Simons C, Patil K, Gaifullina A, Mannal N, Dragicevic E, Spaich D, Müller S, Nemeth J, Hollmann H, Deuter N, Mousba Y, Kubisch C, Poetschke C, Striessnig J, Pongs O, Schneider T, Wade-Martins R, Patel S, Parlato R, Frank T, Kloppenburg P, Liss B (2019): Cav2.3 channels contribute to dopaminergic neuron loss in a model of Parkinson’s disease. NATURE COMM 10:5094; doi: 10.1038/s41467-019-12834-x. PDF

Kreiner G, Sönmez A, Liss B, Parlato R (2019): Integration of the Deacetylase SIRT1 in the Response to Nucleolar Stress: Metabolic Implications for Neurodegenerative Disease. Front. Mol. Neurosci.12:106, doi: 10.3389/fnmol.2019.00106. PDF

Liss B, Kätzel D (2019): Kleinhirn, in Brandes R, Lang F, Schmidt RF: Physiologie des Menschen: mit Pathophysiologie, Springer-Verlag. 978-3-662-56467-7 (ISBN) Link

Jendryka M, Palchaudhuri M, Ursu D, van der Veen B, Liss B, Kätzel D, Nissen W, Pekcec A (2019): Pharmacokinetic and pharmacodynamic actions of clozapine-N-oxide, clozapine, and compound 21 in DREADD-based chemogenetics in mice. Scientific Reports 9:4522. doi: 10.1038/s41598-019-41088-2. PDF

Liss B and Striessnig J (2019): The Potential of L-Type Calcium Channels as a Drug Target for Neuroprotective Therapy in Parkinson's Disease. Annu. Rev. Pharmacol. Toxicol. 59:263-89. doi:10.1146/annurev-pharmatox-010818-021214. PDF

Grimm CM, Aksamaz S, Schulz S, Teutsch J, Sicinski P, Liss B and Kätzel D (2018): Schizophrenia-related cognitive dysfunction in the Cyclin-D2 knockout mouse model of ventral hippocampal hyperactivity. Translational Psychiatry 8:212. doi:10.1038/s41398-018-0268-6. PDF

Duda J, Fauler M, Gründemann J, Liss B (2018): Cell-Specific RNA Quantification in Human SN DA Neurons from Heterogeneous Post-mortem Midbrain Samples by UV-Laser Microdissection and RT-qPCR. Methods Molecular Biology, Vol. 1723: Laser Capture Microdissection, 978-1-4939-7557-0, 428236_3_En, (19) ISBN 978-1-4939-7557-0, doi: 10.1007/978-1-4939-7558-7_19. PDF

Parlato R, Liss B (2017): Selective degeneration of dopamine neurons in Parkinson's disease: emerging roles of altered calcium homeostasis and nucleolar function. De Gruyter, 24:1-143. doi: 10.1515/nf-2017-A006. PDF

Ortner NJ, Bock G, Dougalis A, Kharitonova M, Duda J, Hess S, Tuluc P, Pomberger T, Stefanova N, Pitterl F, Ciossek T, Oberacher H, Draheim HJ, Kloppenburg P, Liss B, Striessnig J (2017): Lower affinity of isradipine for L-type Ca2+ channels during substantia nigra dopamine neuron-like activity: implications for neuroprotection in Parkinson's disease. J Neurosci, 37:6761-6777. doi: 10.1523/JNEUROSCI.2946-16.2017. PDF

Dougalis A, Matthews G, Liss B, Ungless M (2017): Ionic currents influencing spontaneous firing and pacemaker frequency in dopamine neurons of the ventrolateral periaqueductal gray and dorsal raphe nucleus (vlPAG/DRN): A voltage-clamp and computational modelling study. J Comput Neurosci, 42:275-305.doi: 10.1007/s10827-017-0641-0. PDF

Evsyukov V, Domanskyi A, Bierhoff H, Gispert S, Mustafa R, Schlaudraff F, Liss B, Parlato R (2017): Genetic mutations linked to Parkinson's disease differentially control nucleolar activity in pre-symptomatic mouse models. Dis Model Mech, 10:633-643. doi: 10.1242/dmm.028092. PDF

Duda J, Poetschke C, Liss B (2016): Converging roles of ion channels, calcium, metabolic stress, and activity pattern of substantia nigra dopaminergic neurons in health and Parkinson's disease. J Neurochem, 139:156-178. doi: 10.1111/jnc.13572. PDF

Kramer E, Liss B (2015): GDNF-Ret signaling in midbrain dopaminergic neurons and its implication for Parkinson disease. FEBS Lett, 589:3760-72. doi: 10.1016/j.febslet.2015.11.006. PDF

Poetschke C, Dragicevic E, Duda J, Benkert J, Dougalis A, DeZio R, Snutch TP, Striessnig J, Liss B (2015): Compensatory T-type Ca2+ channel activity alters D2-autoreceptor responses of Substantia nigra dopamine neurons from Cav1.3 L-type Ca2+ channel KO mice. Nature Scientific Reports, 5:13688. doi: 10.1038/srep13688. PDF.

Krabbe S, Duda J, Schiemann J, Poetschke C, Schneider G, Kandel ER, Liss B, Roeper J, Simpson EH (2015): Increased dopamine D2 receptor activity in the striatum alters the firing pattern of dopamine neurons in the ventral tegmental area. PNAS, 112:E1498-506. doi: 10.1073/pnas.1500450112. PDF

Dragicevic E, Schiemann J, Liss B (2015): Dopamine midbrain neurons in health and Parkinson's disease: Emerging roles of voltage-gated calcium channels and ATP-sensitive potassium channels. Neuroscience, 284:798-814. doi: 10.1016/j.neuroscience.2014.10.037. PDF

Eschbach J, von Einem B, Müller K, Bayer H, Scheffold A, Morrison BE, Rudolph KL, Thal DR, Witting A, Weydt P, Otto M, Fauler M, Liss B, McLean PJ, La Spada AR, Ludolph AC, Weishaupt JH, Danzer KM (2015): Mutual exacerbation of PGC 1α deregulation and α-synuclein oligomerization. Ann Neurol, 77:15-32. doi: 10.1002/ana.24294. PDF

Mühling T*, Duda J*, Weishaupt J, Ludolph AC, Liss B (2014): Elevated mRNA-levels of distinct mitochondrial and plasma membrane Ca2+ transporters in individual hypoglossal motor neurons of endstage SOD1 transgenic mice. Front Cell Neurosci, 8:353. doi: 10.3389/fncel.2014.00353.  PDF

Dragicevic E, Poetschke C*, Duda J*, Schlaudraff F, Lammel S, Schiemann J, Fauler M, Hetzel A, Watanabe M, Lujan R, Malenka R C, Striessnig J, Liss B (2014): Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. Brain, 137:2287-302. doi: 10.1093/brain/awu131. PDF.  See also: "Scientific Commentaries", Brain (2014): Calcium currents regulate dopamine autoreceptors. PDF

Parlato R, Mandl C, Hölzl-Wenig G, Liss, Tucker KL, Ciccolini F (2014): Regulation of proliferation and histone acetylation in embryonic neural precursors by CREB/CREM signaling. Neurogenesis, 1:e970883-1-12. Doi: 10.4161/23262125.2014.970883. PDF

Schlaudraff F, Gründemann J*, Fauler M*, Dragicevic E, Hardy J, Liss B (2014): Orchestrated increase of dopamine and PARK mRNAs but not miR-133b in dopamine neurons in Parkinson´s disease. Neurobiolb Aging, 35:2302-15. doi: 10.1016/j.neurobiolaging.2014.03.016. PDF

Liss B, Parlato R (2014): How Parkinson's disease meets nucleolar stress. Biochim Biophys Acta, 1842:791-797. doi: 10.1016/j.bbadis. PDF

Kiryk A, Sowodniok K, Kreiner G, Rodriguez-Parkitna J, Sönmez A, Górkiewicz T, Bierhoff H, Wawrzyniak M, Janusz AK, Liss B, Konopka W, Schütz G, Kaczmarek L, Parlato R. (2013): Impaired rRNA synthesis triggers homeostatic responses in hippocampal neurons. Front Cell Neurosci, 7:207. doi: 10.3389/fncel.2013.00207. PDF

Prinz A, Selesnew LM, Liss B, Roeper J, Carlsson T (2013): Increased excitability in serotonin neurons in the dorsal raphe nucleus in the 6-OHDA mouse model of Parkinson's disease. Exp Neurol, 248C:236-245. doi: 10.1016/j.expneurol.2013.06.015. PDF

Kreiner G, Bierhoff H, Armentano M, Rodriguez-Parkitna J, Sowodniok K, Naranjo JR, Bonfanti L, Liss B, Schütz G, Grummt I, Parlato R. (2013): A neuroprotective phase precedes striatal degeneration upon nucleolar stress. Cell Death Differ, 20:1456-64. doi: 10.1038/cdd.2013.66. PDF

Müller SK, Bender A, Laub C, Högen T, Schlaudraff F, Liss B, Klopstock T, Elstner M (2013): Lewy body pathology is associated with mitochondrial DNA damage in Parkinson's disease. Neurobiol Aging, 34:2231-3. doi: 10.1016/j.neurobiolaging.2013.03.016. PDF

Fuchs A, Kutterer S, Mühling T, Duda J, Schütz B, Liss B, Keller BU, Roeper J (2013): Selective mitochondrial Ca2+ uptake deficit in disease endstage vulnerable motoneurons of the SOD1G93A mouse model of amyotrophic lateral sclerosis. J Physiol, 591:2723-45. doi: 10.1113/jphysiol.2012.247981. PDF

Schiemann J, Schlaudraff F, Klose V, Bingmer M, Seino S, Magill PJ, Zaghloul KA, Schneider G, Liss B*, Roeper J* (2012): K-ATP channels in dopamine substantia nigra neurons control bursting and novelty-induced exploration. Nat Neurosci, 15:1275-80. doi:10.1038/nn.3185. PDF.  See also: "News and Views", Silva & Costa (2012): Bursting for exploration. PDF.

Katz SF, Lechel A, Obenauf AC, Begus-Nahrmann Y, Kraus J, Hoffmann EM, Duda J, Eshraghi P, Hartmann D, Liss B, Schirmacher P, Kestler HA, Speicher MR, Rudolph KL (2012): Disruption of Trp53 in Livers of Mice Induces Formation of Carcinomas with Bilineal Differentiation. Gastroenterology, 142:1229-1239.e3. doi: 10.1053/j.gastro.2012.02.009. PDF

Elstner M, Müller SK, Leidolt L, Laub C, Krieg L, Schlaudraff F, Liss B, Morris C, Turnbull DM, Masliah E, Prokisch H, Klopstock T, Bender A (2011): Neuromelanin, neurotransmitter status and brainstem location determine the differential vulnerability of catecholaminergic neurons to mitochondrial DNA deletions. Molecular Brain, 4:43. doi: 10.1186/1756-6606-4-43. PDF

Sperka T, Song Z, Morita Y, Nalapareddy K, Guachalla LM, Lechel A, Begus-Nahrmann Y, Burkhalter MD, Mach M, Schlaudraff F, Liss B, Ju Z, Speicher MR, Rudolph KL. (2011): Puma and p21 represent cooperating checkpoints limiting self-renewal and chromosomal instability of somatic stem cells in response to telomere dysfunction. Nat Cell Biol, 14:73-9. doi: 10.1038/ncb2388. PDF

Gruendemann J, Schlaudraff F, Liss B (2011): UV-laser microdissection and mRNA expression analysis of individual neurons from postmortem Parkinson‘s disease brains. Methods Mol Biol, 755:363-74. doi: 10.1007/978-1-61779-163-5_30. PDF

Rolyan H, Scheffold A, Begus-Nahrmann Y, Heinrich A, Liss B , Langkopf BH, Hölter SM, Vogt Weisenhorn DM,  Wurst W, Chichung Lie D, Thal DR, Biber K, Rudolph KL (2011): Telomere shortening reduces Alzheimer’s disease amyloid pathology in mice. Brain, 134:2044-56. doi: 10.1093/brain/awr133. PDF

Kurz A, Double KL, Lastres-Becker I, Tozzi A, Tantucci M, Bockhart V, Bonin M, García-Arencibia M, Nuber S, Schlaudraff , Liss B, Fernández-Ruiz  J, Gerlach M, Wüllner U, Lüddens H, Calabresi P, Auburger G, Gispert S (2010): A53T-Alpha-Synuclein Overexpression Impairs Dopamine Signaling and Striatal Synaptic Plasticity in Old Mice. PLoS One, 5:1-15. doi: 10.1371/journal.pone.0011464. PDF

Liss B, Roeper J (2010): A new tool for your novelty centre. J Physiol, 588:2013. doi: 10.1113/jphysiol.2010.192203. PDF

Dietl P, Liss B, Felder E, Miklavc P, Wirtz H (2010): Lamellar Body Exocytosis by Cell Stretch or Purinergic Stimulation: Possible Physiological Roles, Messengers and Mechanisms. Cell Physiol Biochem, 25:01-12. doi: 10.1159/000272046. PDF  

Liss B, Roeper J (2010): Ion channels and regulation of dopamine neuron activity. Buchbeitrag in: The Dopamine Handbook; Oxford University Press. Edited by A. Bjorklund, S. Dunnett, L. Iversen, S. Iversen. Google-books link ISBN: 0195373030.

Begus-Nahrmann Y, Lechel A, Obenauf AC, Nalapareddy K, Peit E, Hoffmann E, Schlaudraff F, Liss B , Schirmacher P, Kestler H, Danenberg E, Barker N, Clevers H, Speicher MR, Rudolph KL (2009): p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice. Nat Genet, 41:1138-43. doi: 10.1038/ng.426. PDF

Liss B, Roeper J (2008): Indivdual dopamine midbrain neurons: Functional diversity and flexibility in health and disease. Brain Res Rev, 58:314-321. doi: 10.1016/j.brainresrev.2007.10.004. PDF

Gründemann J, Schlaudraff F, Haeckel O, Liss B (2008): Elevated alpha-synuclein mRNA levels in individual UV-laser-microdissected dopaminergic substantia nigra neurons in idiopathic Parkinson's disease. Nucleic Acids Res, 36:e38. doi: 10.1093/nar/gkn084. PDF

Lammel S, Hetzel A, Haeckel O, Jones I, Liss B*, Roeper J* (2008): Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system. Neuron, 57:760-73. doi: 10.1016/j.neuron.2008.01.022. PDF. See also: preview, in same issue, Ford & Williams (2008) PDF. Nature Reviews Neuroscience Highlights (May 2008). PDF

Tricario D, Mele A, Liss B , Ashcroft FM, Lundquist AL, Desai RR, George AL, Conte Camerino D (2008): Reduced expression of Kir6.2/SUR2A subunits explains KATP deficiency in K+-depleted rats. Neuromuscul Disord, 18:74-80. doi: 10.1016/j.nmd.2007.07.009. PDF

Aguado C, Colon J, Ciruela F, Schlaudraff F, Cabanero MJ, Watanabe M, Liss B, Wickman K, Lujan R (2007): Cell type-specific subunit composition of G protein-gated potassium channels in the cerebellum. J Neurochem, 105:497-511. doi: 10.1111/j.1471-4159.2007.05153.x. PDF

Schulz D, Baines RA, Hempel CM, Li L, Liss B, Misonou H (2006): Cellular Excitability and the Regulation of Functional Neuronal Identity: From Gene Expression to Neuromodulation. J Neurosci, 26:10362-7. doi: 10.1523/JNEUROSCI.3194-06.2006. PDF

Ramirez A, Heimbach A, Gruendemann J, Stiller B, Hampshire D, Cid LP, Goebel I, Mubaidin AF, Wriekat AL, Roeper J, Al-Din A, Hillmer AM, Karsak M, Liss B, Woods CG, Behrens MI, Kubisch C (2006): Hereditary parkinsonism with dementia is caused by mutations in ATP13A2, encoding a lysosomal type 5 P-type ATPase. Nat Genet, 38:1184-91. doi: 10.1038/ng1884. PDF

Deacon RM, Brook RC, Meyer D, Haeckel O, Ashcroft FM, Miki T, Seino S, Liss B (2006): Behavioral phenotyping of mice lacking the KATP channel subunit Kir6.2. Physiol Behavi, 87:723-733. doi: 10.1016/j.physbeh.2006.01.013. PDF

Liss B*, Haeckel O, Wildmann J, Miki T, Seino S and Roeper J (2005): K-ATP channels promote the differential degeneration of dopaminergic midbrain neurons. Nature Neurosci, 8:1272-51. doi: 10.1038/nn1570. PDF

See also: "News and Views", Deutch&Winder (2006): A channel to neurodegeneration. Nature Medicine. PDF. "ScienceSTKE", Michel et al (2006): PDF

Liss B, Roeper J (2004): Correlating function and gene expression of individual basal ganglia neurons. Trends in Neurosci 27: 475-481. doi: 10.1016/j.tins.2004.06.007. PDF.

Smart T, et al (2004): Ion channel questionaire. Nature Reviews Drug Discovery, 3: 239-278. PDF

Burdakov D*, Liss B* and Ashcroft FM (2003): Orexin excites GABAergic neurons of the arcuate nucleus by activating the sodium-calcium exchanger. J Neurosci, 23:4951-4957. doi: 10.1523/JNEUROSCI.23-12-04951.2003. PDF

Liss B (2003): Patch clamping - not just for beginners (book review). Molecular Membrane Biology, 20: 193. doi: 10.1080/0698768031000098555.

Liss B (2002): Improved quantitative real-time RT-PCR for expression profiling of individual cells. Nucleic Acids Res, 30:e89. PDF

Neuhoff H*, Neu A*, Liss B, Roeper J (2002): Ih channels contribute to the different functional properties of identified dopaminergic subpopulations in the midbrain. J Neurosci, 22:1290-1302. PDF

Liss B, Franz O, Sewing S, Bruns R, Neuhoff H and Roeper J (2001): Tuning the pacemaker frequency of individual dopaminergic neurons by Kv4.3L and KChip3.1 transcription. EMBO J, 20:5715-5724 doi: 10.1093/emboj/20.20.5715. PDF

Liss B, Roeper J (2001): A role for neuronal KATP channels in metabolic control of the seizure gate. Trends Pharmacol Sci, 22:599-601. doi: 10.1016/S0165-6147(00)01861-7. PDF

Liss B, Roeper J (2001): ATP-sensitive potassium channels in dopaminergic neurons: transducers of mitochondrial dysfunction. News Physiol Sci, 16:214-217. doi: 10.1152/physiologyonline.2001.16.5.214. PDF.

Miki T*, Liss B*, Minami K, Shiuchi T, Saraya A, Kashima Y, Horiuchi M, Ashcroft F, Minokoshi Y, Roeper J and Seino S (2001): ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nat Neurosci, 4:507-512. doi: 10.1038/87455. PDF

Liss B, Roeper J (2001): Molecular Physiology of Neuronal K-ATP channels. Mol Membr Biol, 18:117-127. doi: 10.1080/09687680110047373. PDF

Franz O, Liss B, Neu A and Roeper J (2000): Single-cell mRNA expression of HCN1 correlates with a fast gating phenotype of hyperpolarization-activated cyclic nucleotide-gated ion channels (Ih) in mouse central neurons. Eur J Neurosci, 12:2685-2693. doi: 10.1046/j.1460-9568.2000.00151.x. PDF

Sakura H, Trapp S, Liss B, Ashcroft FM (1999): Altered functional properties of K-ATP channel conferred by a novel splice variant of SUR1. Journal of Physiology (London), 521:337-350. doi: 10.1111/j.1469-7793.1999.00337.x. PDF

Liss B, Neu A and Roeper J (1999): The weaver mouse gain-of-function phenotype of dopaminergic midbrain neurons is determined by coactivation of wvGirk2 and K-ATP channels. J Neurosci, 19:8839-8848. doi: 10.1523/JNEUROSCI.19-20-08839.1999. PDF

Liss B, Bruns R and Roeper J (1999): Alternative sulphonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons. EMBO J, 18:833-846. doi:10.1093/emboj/18.4.833. PDF

Liss B (1999): Differentielle Expression von Kaliumkanälen in Substantia nigra Neuronen der Maus (Mus musculus L.) - Eine kombinierte Patch-Clamp- und Einzelzell-PCR-Studie an Hirnschnitten, "Verlag", Band 48, ISBN: 3-933342-48-1. PDF

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Orexine (1998), Laborjournal