Publications Grissmer-Lab

* equally contributing authors / shared corresponding authors

  Alexander SPH et al. 2019.  The Concise Giude to Pharmacology 2019/20: G protein-coupled receptors. British Journal of Pharmacology 176:21-141. PDF

 Attali B, Chandy KG, Giese MH, Grissmer S, Gutman GA, Jan LY, Lazdunski M, Mckinnon D, Nerbonne J, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stühmer W, Trimmer JS, Wang X: Voltage-gated potassium channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. IUPHAR/BPS Guide to Pharmacology CITE (2019) PDF; Link

 Tyutyaev P, Grissmer S.  2018.  Characterization of the σ-pore in mutant hKv1.3 potassium channels.  Cellular Physiology and Biochemistry 46:1112-1121. PDF

 Diesch A, Grissmer S.  2017.  Kinetic aspects of verapamil binding (on-rate) on wild type and six hKv1.3 mutant channels.  Cellular Physiology and Biochemistry 44:172-184. PDF

  Alexander SPH et al. 2017.  The Concise Giude to Pharmacology 2017/18: Overview. British Journal of Pharmacology 174:1-16. PDF

 Tyutyaev P, Grissmer S.  2017.  Observation of σ-pore currents in mutant hKv1.2_V370C potassium channels.  PLoS One 12(4):e0176078. doi: 10.1371/journal.pone.0176078. eCollection 2017. PDF

 Kaczmarek LK, Aldrich RW, Chandy KG, Grissmer S, Wei AD, Wulff H.  2017.  International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels.  Pharmacological Reviews 69:1–11. PDF

  Alexander SPH et al. 2015.  The Concise Giude to Pharmacology 2015/16: Overview. British Journal of Pharmacology 172:5729-5743. PDF

 Janbein M, Abo Quader M, Hoppner AC, Grüner I, Wanker E, Wälter S, Küppers E, Grissmer S, Jäger H.  2014.  Evidence for the interaction of Endophilin A3 with endogeneous KCa2.3 channels in PC12 cells.  Cellular Physiology and Biochemistry 34(2):274-290. PDF

 Nikouee A, Janbein M, Grissmer S.  2012.  Verapamil- and state-dependent effect of 2-aminoethylmethanethiosulphonate (MTSEA) on hKv1.3 channels.  British Journal of Pharmacology167(6):1378-1388. PDF

 Nikouee A, Khabiri M, Grissmer S, Ettrich R.  2012.  Charybdotoxin and margatoxin acting on the human voltage-gated potassium channel hKv1.3 and its H399N mutant: An experimental and computational comparison.  The Journal of Physical Chemistry B 116(17):5132-5140. PDF

 Grissmer S.  2012.  Passing through the eye of the needle.  International Innovation Healthcare 14:30-32. PDF

 Khabiri M, Nikouee A, Cwiklik L, Grissmer S, Ettrich R.  2011.  Charybdotoxin unbinding from the mKv1.3 potassium channel: A combined computational and experimental Study.  The Journal of Physical Chemistry B 115(39):11490-11500. PDF

 Prütting S, Grissmer S.  2011.  A novel current pathway parallel to the central pore in a mutant voltage-gated potassium channel.  Journal of Biological Chemistry 286:20031-20042. PDF

 Schmid SI, Grissmer S.  2011.  Effect of verapamil on the action of methanethiosulfonate reagents on voltage-gated hKv1.3 channels: implications for the C-type inactivated state.  British Journal of Pharmacology 163(3):662-674. PDF

 Rossokhin A, Dreker T, Grissmer S, Zhorov B.  2011.  Why does the inner-helix mutation A413C double the stoichiometry of the Kv1.3 channel block by emopamil but not by verapamil.  Molecular Pharmacology 79(4):681-691. PDF

 Svoboda N, Prütting S, Grissmer S, Kerschbaum HH.  2009.  cAMP-dependent chloride conductances evokes ammonia-induced blebbing in the microglial cell line, BV-2.  Cellular Physiology and Biochemistry 24(1-2):53-64. PDF

 Pegoraro S, Lang M, Dreker T, Kraus J, Hamm S, Meere C, Feurle J, Tasler S, Prütting S, Kuras Z, Visan V, Grissmer S.  2009.  Inhibitors of potassium channels Kv1.3 and IK-1 as immunosuppressants.  Bioorganic and Medicinal Chemistry Letters 19(8):2299-2304. PDF

 Kuras Z, Grissmer S.  2009.  Effect of K+ and Rb+ on the action of verapamil on a voltage-gated K channel, hKv1.3: implications for a second open state?  British Journal of Pharmacology 157(5):757-768. PDF

 Grissmer S.  2008.  SK-Ca3 Small Conductance Calcium Activated Potassium Channels.  xPharm: The Comprehensive Pharmacology Reference, Pages 1-12. PDF

 Grissmer S.  2008.  SK-Ca2 Small Conductance Calcium Activated Potassium Channels.  xPharm: The Comprehensive Pharmacology Reference, Pages 1-7. PDF

 Grissmer S.  2008.  SK-Ca1 Small Conductance Calcium Activated Potassium Channels.  xPharm: The Comprehensive Pharmacology Reference, Pages 1-7. PDF

 Grissmer S.  2008.  IK-Ca Intermediate Conductance Calcium Activated Potassium Channels.  xPharm: The Comprehensive Pharmacology Reference, Pages 1-9. PDF

 Grissmer S.  2008.  Calcium-Sensitive Potassium Channels.  xPharm: The Comprehensive Pharmacology Reference, Pages 1-4. PDF

 Küppers E, Gleiser C, Brito V, Wachter B, Pauly T, Hirt B, Grissmer S.  2008.  AQP4 expression in striatal primary cultures is regulated by dopamine - implications for proliferation of astrocytes.  European Journal of Neuroscience 28:2173-2182. PDF

 Murthy SR, Teodorescu G, Nijholt IM, Dolga AM, Grissmer S, Spiess J, Blank T.  2008.  Identification and Characterization of a Novel, Shorter Isoform of the Small Conductance Ca(2+)- Activated K(+) Channel SK2.  Journal of Neurochemistry 106(6):2312-2321. PDF

 Zierler S, Frei E, Grissmer S, Kerschbaum HH.  2008.  Chloride influx provokes lamellipodium formation in microglial cells.  Cellular Physiology and Biochemistry 21(1-3):55-62. PDF

 Pimentel C, M'barek S, Visan V, Grissmer S, Sampieri F, Sabatier JM, Darbon H, Fajloun Z.  2008.  Chemical synthesis and 1H-NMR 3D structure determination of AgTx2-MTX chimera, a new potential blocker for Kv1.2 channel, derived from MTX and AgTx2 scorpion toxins.  Protein Science 17(1):107-118. PDF

 Liebau S, Vaida B, Grissmer S, Storch A, Böckers T, Dietl P, Wittekindt OH.  2007.  Formation of cellular projections in neural progenitor cells depends on SK3 channel activity.  Journal of Neurochemistry 101:1338-1350. PDF

 Frei E, Spindler I, Grissmer S, Jäger H.  2006.  Interaction of N-terminal and C-terminal parts of the small conductance Ca2+ activated K+ channels, hSK3.  Cellular Physiology and Biochemistry 18(4-5):165-176. PDF

 Liebau S, Pröpper C, Böckers T, Lehmann-Horn F, Storch A, Grissmer S, Wittekindt OH.  2006.  Selective blockage of Kv1.3 and Kv3.1 channels increases neural progenitor cell proliferation.  Journal of Neurochemistry 99(2):426-437. PDF

 Rossokhin A, Teodorescu GA, Grissmer S, Zhorov B.  2006.  Interaction of d-tubocurarine with potassium channels: Molecular modeling and ligand binding.  Molecular Pharmacology 69(4):1356-1365. PDF

 Mouhat S, Teodorescu G, Homerick D, Visan V, Wulff H, Wu Y, Grissmer S, Darbon H, De Waard M, Sabatier JM.  2006.  Pharmacological profiling of Orthochirus scrobiculosus toxin 1 analogues with a trimmed N-terminal domain.  Molecular Pharmacology 69(1):354-362. PDF

 Wittekindt OH, Schmitz A, Lehmann-Horn F, Hänsel W, Grissmer S.  2006.  The human Ca2+-activated K+ channel, IK, can be blocked by the tricyclic antihistamine promethazine.  Neuropharmacology 50(4):458-467. PDF

 Gutman GA, Chandy KG, Grissmer S, Lazdunski M, McKinnon D, Pardo LA, Robertson GA, Rudy B, Sanguinetti MC, Stuhmer W, Wang X.  2005.  International Union of Pharmacology. LIII. Nomenclature and Molecular Relationships of Voltage-Gated Potassium Channels.  Pharmacological Reviews 57(4):473-508. PDF

 Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H.  2005.  International Union of Pharmacology. LII. Nomenclature and Molecular Relationships of Calcium-Activated Potassium Channels.  Pharmacological Reviews 57(4):463-472. Link

 Dreker T, Grissmer S.  2005.  Investigation of the phenylalkylamine binding site in hKv1.3 (H399T), a mutant with a reduced C-type inactivated state.  Molecular Pharmacology 68(4):966-973. PDF

 M'Barek S, Chagot B, Andreotti N, Visan V, Mansuelle P, Grissmer S, Marrakchi M, El Ayeb M, Sampieri F, Darbon H, Fajloun Z, De Waard M, Sabatier JM.  2005.  Increasing the molecular contacts between maurotoxin and Kv1.2 channel augments ligand affinity.  Proteins 60(3):401-411. PDF

 Mouhat S, Visan V, Ananthakrishnan S, Wulff H, Andreotti N, Grissmer S, Darbon H, De Waard M, Sabatier JM.  2005.  K+ channel types targeted by synthetic OSK1, a potent toxin from Orthochirus scrobiculosis scorpion venom.  Biochemical Journal 385(Pt 1):95-104. PDF

 Visan V, Fajloun Z, Sabatier JM, Grissmer S.  2004.  Mapping of maurotoxin binding sites on hKv1.2, hKv1.3 and hIKCa1 channels.  Molecular Pharmacology 66:1103-1112. PDF

 Visan V, Sabatier JM, Grissmer S.  2004.  Block of maurotoxin and charybdotoxin on human intermediate-conductance calcium-activated potassium channels (hIKCa1).  Toxicon 43:973-980. PDF

 Jäger H, Grissmer S.  2004.  Characterization of the outer pore region of the apamin-sensitive Ca2+-activated K+ channel, rSK2.  Toxicon 43:951-960. PDF

 Grissmer S, Tytgat J.  2004.  Toxins and potassium channels.  Toxicon 43:863. PDF

 Vennekamp J, Wulff H, Beeton C, Calabresi PA, Grissmer S, Hänsel W, Chandy KG.  2004.  Kv1.3-Blocking 5-Phenylalkoxypsoralens: A New Class of Immunomodulators.  Molecular Pharmacology 65:1364-1374. PDF

 Wittekindt OH, Visan V, Tomita H, Amhad F, Gargus JJ, Lehmann-Horn F, Grissmer S, Morris-Rosendahl D.  2004.  An apamin- and scyllatoxin-insensitve isoform of the human SK3 channel.  Molecular Pharmacology 65:788-801. PDF

 Jäger H, Dreker T, Buck A,  Giehl K, Gress T, Grissmer S.  2004.  Blockade of Ca2+-activated K+ channels, IK, inhibits human pancreatic cancer cell growth in vitro.  Molecular Pharmacology 65:630-638. PDF

 Wittekindt OH, Dreker T, Morris-Rosendahl DJ, Lehmann-Horn F, Grissmer S.  2004.  A novel non-neuronal hSK3 isoform with a dominant-negative effect on hSK3 currents.  Cellular Physiology and Biochemistry 14(1-2):23-30. PDF

 Jouirou B, Mosbah A, Visan V, Grissmer S, M’Barek S, Fajloun Z, Van Rietschoten J, Rochat H, Lippens G, El Ayeb M, De Waard M, Mabrouk K, Sabatier JM.  2004.  Cobatoxin 1 from Centruroides noxius scorpion venom: Chemical synthesis, 3-D structure in solution, pharmacology and docking on K+ channels.  Biochemical Journal 377(Pt 1):37-49. PDF

 Mouhat S, Mosbah A, Visan V, Wulff H, Delepierre M, Darbon H, Grissmer S, De Waard M, Sabatier JM.  2004.  The "functional" dyad of scorpion toxin Pi1 is not per se a prerequisite for toxin binding to the voltage-gated Kv1.2 potassium channels.  Biochemical Journal 377(Pt 1):25-36. PDF

 Gutman GA, Chandy KG, Adelman JP, Aiyar J, Bayliss DA, Clapham DE, Covarriubias M, Desir GV, Furuichi K, Ganetzky B, Garcia ML, Grissmer S, Jan LY, Karschin A, Kim D, Kuperschmidt S, Kurachi Y, Lazdunski M, Lesage F, Lester HA, McKinnon D, Nichols CG, O'Kelly I, Robbins J, Robertson GA, Rudy B, Sanguinetti M, Seino S, Stuehmer W, Tamkun MM, Vandenberg CA, Wei A, Wulff H, Wymore RS.  2003.  International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels.  Pharmacolocal Reviews 55(4):583-586. Link

 M’Barek S, Lopez-Gonzales I, Andreotti N, di Luccio E, Visan V, Grissmer S, Mosbah A, Judge S, El Ayeb M, Darbon H, Rochat H, Beraud E, Fajloun Z, De Waard M, Sabatier JM.  2003.  A Maurotoxin with constrained standard disulfide bridging – Innovative strategy of chemical synthesis, pharmacology and docking on K+ channels.  Journal of Biological Chemistry 278(33):31095-31104. PDF

 Bräuer M, Frei E, Claes L, Grissmer S, Jäger H.  2003.  Influence of the K/Cl cotransporter activity on the activation of volume-sensitive Cl- channels in human osteoblasts.  American Journal of Physiology 285(1):C22-30. PDF

 Gilquin B, Racape J, Wrisch A, Visan V, Lecoq A, Grissmer S, Menez A, Gasparini S.  2002.  Structure of the BgK-Kv1.1 complex based on distance restrainst identified by double mutant cycles. Molecular basis for convergent evolution of Kv1 channel blockers.  Journal of Biological Chemistry 277:37406-37413. PDF

 Kerschbaum HH, Grissmer S, Engel E, Richter K, Lehner C, Jäger H.  2002.  A Shaker homologue encodes an A type current in Xenopus laevisBrain Research 927(1):55-68. PDF

 Jäger H, Grissmer S.  2001.  Regulation of a mammalian Shaker-related potassium channel, hKv1.5, by extracellular potassium and pH.  FEBS Letters 488(1-2):45-50. PDF

 Röbe R, Grissmer S.  2000.  Block of the lymphocyte K+ channel mKv1.3 by the phenylalkylamine verapamil: kinetic aspects of block and disruption of accumulation of block by a single pointy mutation.  British Journal of Pharmacology 131(7):1275-1284. PDF

 Weskamp M, Seidl W, Grissmer S.  2000.  Characterization of the Increase in [Ca2+]i During Hypotonic Shock and the Involvement of Ca2+-activated K+ Channels in the Regulatory Volume Decrase in Human Osteoblast-like Cells.  The Journal of Membrane Biology 178(1):11-20. PDF

 Wrisch A, Grissmer S.  2000.  Structural differences of bacterial and mammalian K+ channels.  Journal of Biological Chemistry 275(50):39345-39352. PDF

 Wulff H, Miller M, Hänsel W, Grissmer S, Cahalan MD, Chandy KG.  2000.  Design of a potent and selective inhibitor of the intermediate conductance Ca2+-activated K+ channel, IKCa1: a potential immunosuppressant.  Proceedings of the National Academy of Sciences, USA 97:8151-8156. PDF

 Jäger H, Adelman JP, Grissmer S.  2000.  SK2 encodes the apamin-sensitive Ca2+-activated K+ channels in the human leukemic T cell line, Jurkat.  FEBS Letters 469(2-3):196-202. PDF

 Siemer C, Bushfield M, Newgreen D, Grissmer S.  2000.  Effects of NS1608 on MaxiK channels in smooth muscle cells from urinary bladder.  Journal of Membrane Biology 173(1):57-66. PDF

 Rauer H, Grissmer S.  1999.  The effect of deep pore mutations on the action of phenylalkylamines on the Kv1.3 potassium channel.  British Journal of Pharmacology 127:1065-1074. PDF

 Bretschneider F, Wrisch A, Lehmann-Horn F, Grissmer S.  1999.  Expression in mammalian cells and electrophysiological characterization of two mutant Kv1.1 channels causing episodic ataxia type 1.  European Journal of Neuroscience 11(7):2403-2412. PDF

 Hanson DC, Nguyen AN, Mather RJ, Rauer H, Koch K, Burgess LE, Rizzi JP, Donovan CB, Bruns MJ, Canniff PC, Cunningham AC, Verdries KA, Mena E, Kath JC, Gutman GA, Cahalan MD, Grissmer S, Chandy KG.  1999.  UK-78,282, a novel piperidine compound that potently blocks the Kv1.3 voltage-gated potassium channel and inhibits human T cell activation.  British Journal of Pharmacology 126:1707-1716. PDF

 Bretschneider F, Wrisch A, Lehmann-Horn F, Grissmer S.  1999.  External tetraethylammonium (TEA+) as a molecular caliper for sensing the shape of the outer vestibule of potassium channels.  Biophysical Journal 76(5):2351-2360. PDF

 Siemer C, Grissmer S.  1999.  MaxiK channels: molecular structure, function, and tissue distribution. Perspectives in drug discovery and design: Animal toxins and potassium channels 15/16:155-165. PDF

 Kalman K, Pennington M, Lanigan MD, Nguyen AN, Rauer H, Mahnir V, Paschetto K, Kem WR, Grissmer S, Gutman GA, Christian E, Cahalan MD, Norton R, Chandy KG.  1998.  ShK-Dap22, a potent Kv1.3-specific immunosuppressive polypeptide.  Journal of Biological Chemistry 273(49):32697-32707. PDF

 Wulff H, Rauer H, Düring T, Hanselmann C, Ruff K, Wrisch A, Grissmer S, Hänsel W.  1998.  Alkoxypsoralens - Novel nonpeptide blockers of Shaker-type K+ channels: synthesis and photoreactivity.  Journal of Medicinal Chemistry 41(23):4542-4549. PDF

 Jäger H, Rauer H, Nguyen AN, Aiyar J, Chandy KG, Grissmer S.  1998.  Regulation of mammalian Shaker-related K+ channels: evidence for non-conducting closed and non-conducting inactivated states.  Journal of Physiology 506.2:291-301. PDF

 Grissmer S.  1997.  Potassium channels still hot.  Trends in Pharmacological Sciences 18:347-350. PDF

 Jäger H, Grissmer S.  1997.  Small Ca2+-activated potassium channels in human leukemic T cells and activated human peripheral blood T lymphocytes.  Cellular Physiology and Biochemistry 7(3):179-187. Link

 Steinert M, Grissmer S.  1997.  Novel activation stimulus of chloride channels by potassium in human osteoblasts and human leukemic T lymphocytes.  Journal of Physiology 500.3:653-660. PDF

 Nguyen A, Kath J, Hanson DC, Biggers MS, Kaniff PC, Donovan C, Mather RJ, Bruns M, Dethlefs B, Rauer H, Aiyar J, Lepple-Wienhues A, Gutman GA, Grissmer S, Cahalan MD, Chandy KG.  1996.  Novel non-peptide agents block the C-type inactivated conformation of Kv1.3, and suppress T-cell activation.  Molecular Pharmacology 50:1672-1679. Link

 Rauer H, Grissmer S.  1996.  Evidence for an internal phenylalkylamine action on the voltage-gated potassium channel Kv1.3.  Molecular Pharmacology 50:1625-1634. Link

 Hanselmann C, Grissmer S.  1996.  Characterization of apamin-sensitive Ca2+-activated potassium channels in Jurkat T cells.  Journal of Physiology 496.3:627-637. PDF

 Aiyar J, Nguyen AN, Chandy KG, Grissmer S.  1994.  The P-region and S6 of Kv3.1 contribute to the formation of the ion conduction pathway.  Biophysical Journal 67:2261-2264. PDF

 Grissmer S, Nguyen AN, Aiyar J, Hanson DC, Mather RJ, Gutman GA, Karmilowicz MJ, Auperin DD, and Chandy KG.  1994.  Pharmacological characterization of five cloned voltage-gated K+ channels, Kv1.1, Kv1.2, Kv1.3, Kv1.5, and Kv3.1, stably expressed in mammalian cell lines.  Molecular Pharmacology 45:1227-1234. Link

 Aldenhoff J, Grissmer S, Müller W.  1994.  Cell, calcium and psychiatry.  European Archives of Psychiatry and Clinical Neuroscience 243:213. PDF

 Aiyar J, Grissmer S, Chandy KG.  1993.  Full-length and truncated Kv1.3 K+ channels are modulated by 5-HT1C receptor activation and independently by PKC.  American Journal of Physiology 265(Cell Physiol.34):C1571-C1578. PDF

 Grissmer S, Nguyen AN, Cahalan MD.  1993.  Calcium-activated potassium channels in resting and activated human T lymphocytes. Expression levels, calcium dependence, ion selectivity, and pharmacology.  Journal of General Physiology 102:601-630. PDF

 Chandy KG, Gutman GA, Grissmer S.  1993.  Physiological role, molecular structure, and evolutionary relationships of voltage-gated potassium channels in T lymphocytes.  Seminars in The Neurosciences 5:125-134. PDF

 Grissmer S, Ghanshani S, Dethlefs B, McPherson J, Wasmuth JJ, Gutman GA, Cahalan MD, Chandy KG.  1992.  The Shaw-related Potassium-Channel Gene, Kv3.1, on Human Chromosome 11, Encodes the Type l K+ channel in T Cells.  Journal of Biological Chemistry 267(29):20971-20979. PDF

 Grissmer S, Lewis RS, Cahalan MD.  1992.  Ca2+-activated K+ channels in a human leucemic T-cell line.  Journal of General Physiology 99:63-87. PDF

 Cahalan MD, Chandy KG, Grissmer S.  1991.  Potassium channels in development, activation, and disease in T lymphocytes.  In: Current Topics in Membranes. Developmental Biology of Membrane Transport Systems, ed. Benos DJ. 39:357-394. Link

 Grissmer S, Dethlefs B, Wasmuth JJ, Goldin AL, Gutman GA, Cahalan MD, Chandy KG.  1990.  Expression and chromosomal localization of a lymphocyte K+ channel gene. Proceedings of the National Academy of Sciences, USA 87:9411-9416. PDF

 Grissmer S, Hanson DC, Natoli EJ, Cahalan MD, Chandy KG.  1990.  CD4-CD8- T cells from mice with collagen arthritis display aberrant expression of type l K+ channels.  Journal of Immunology 145:2105-2109. PDF

 Chandy KG, Cahalan MD, Grissmer S.  1990.  Autoimmune diseases linked to abnormal K+ channel expression in double-negative CD4-CD8- T cells.  European Journal of Immunology 20:747-751. PDF

 Grissmer S, Cahalan MD.  1989.  Divalent ion trapping inside potassium channels of human T lymphocytes.  Journal of General Physiology 93:609-630. PDF

 Grissmer S, Cahalan MD.  1989.  TEA prevents inactivation while blocking open K+ channels in human T lymphocytes.  Biophysical Journal 55:203-206. PDF

 Grissmer S, Cahalan MD, Chandy KG.  1988.  Abundant expression of type l K+ channels: a marker for lymphoproliferative diseases?  Journal of Immunology 141:1137-1142. PDF

 Grissmer S.  1986.  Properties of potassium and sodium channels in frog internode.  Journal of Physiology 381:119-134. PDF

 Grissmer S.  1984.  Effect of various cations and anions on the action of tetrodotoxin and saxitoxin on frog myelinated nerve fibres.  Pflügers Archiv European Journal of Physiology 402:353-359. PDF