C4: The role of stem cell circulation in trauma
PI: H. Geiger
Trauma results in mobilisation of bone marrow residing stem cells, including haematopoietic, mesenchy-mal and endothelial stem cells. There is evidence that such endogenously mobilized stem cells or exoge-nously provided stem cells are beneficial in trauma therapy. Mechanisms and biological importance though of trauma-induced endogenous mobilisation have not been investigated in great detail, precluding further rationale approaches for using stem cell mobilisation for the treatment of traumatic injuries. We hypothesize that distinct stem cell populations (haematopoietic, endothelial and mesenchymal) are mobi-lized upon trauma by distinct but also unique biological mechanisms and contribute significantly to regen-eration of trauma injury. In this proposal we will determine the extent of mobilisation of distinct stem cell populations in response to trauma, investigate the underlying mechanism of mobilisation and the extent of the therapeutic benefit of spontaneous but also induced endogenous mobilisation. Overall, we will de-lineate the role of stem cell mobilisation in trauma and might provide mechanistic rationale for novel ther-apeutic approaches to harvest stem cell mobilisation for trauma treatment.