Zusammenstellung von Bildern aus dem Sonderforschungsbereich

Publikationen aus dem SFB 1149

2015

51.
K. Wagner, M. Groger, O. McCook, A. Scheuerle, P. Asfar, B. Stahl, M. Huber-Lang, A. Ignatius, B. Jung, M. Duechs, P. Möller, M. Georgieff, E. Calzia, P. Radermacher and F. Wagner, "Blunt Chest Trauma in Mice after Cigarette Smoke-Exposure: Effects of Mechanical Ventilation with 100 % O2", PLoS One, vol. 10, no. 7, pp. e0132810, 2015.
DOI:10.1371/journal.pone.0132810
Datei:http://www.ncbi.nlm.nih.gov/pubmed/26225825
50.
D. Langgartner, A. M. Fuchsl, N. Uschold-Schmidt, D. A. Slattery and S. O. Reber, "Chronic subordinate colony housing paradigm: a mouse model to characterize the consequences of insufficient glucocorticoid signaling", Front Psychiatry, vol. 6, pp. 18, 2015.
DOI:10.3389/fpsyt.2015.00018
Datei:https://www.ncbi.nlm.nih.gov/pubmed/25755645
49.
H. Barth, S. Fischer, A. Moglich and C. Fortsch, "Clostridial C3 Toxins Target Monocytes/Macrophages and Modulate Their Functions", Front Immunol, vol. 6, pp. 339, 2015.
DOI:10.3389/fimmu.2015.00339
Datei:https://www.ncbi.nlm.nih.gov/pubmed/26175735
48.
P. Asfar and P. Radermacher, "Drug-Induced "Suspended Animation": Can a Dream Become True?", Crit Care Med, vol. 43, no. 7, pp. 1528-30, 2015.
DOI:10.1097/CCM.0000000000000985
Datei:https://www.ncbi.nlm.nih.gov/pubmed/26079228
47.
S. Denk, R. Wiegner, F. M. Hones, D. A. Messerer, P. Radermacher, M. Weiss, M. Kalbitz, C. Ehrnthaller, S. Braumuller, O. McCook, F. Gebhard, S. Weckbach and M. Huber-Lang, "Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma", Mediators Inflamm, vol. 2015, pp. 463950, 2015.
DOI:10.1155/2015/463950
Datei:https://www.ncbi.nlm.nih.gov/pubmed/26556956
46.
J. Kemmler, R. Bindl, O. McCook, F. Wagner, M. Groger, K. Wagner, A. Scheuerle, P. Radermacher and A. Ignatius, "Exposure to 100% Oxygen Abolishes the Impairment of Fracture Healing after Thoracic Trauma", PLoS One, vol. 10, no. 7, pp. e0131194, 2015.
DOI:10.1371/journal.pone.0131194
Datei:http://www.ncbi.nlm.nih.gov/pubmed/26147725
45.
P. Xu, P. Fischer-Posovszky, J. Bischof, P. Radermacher, M. Wabitsch, D. Henne-Bruns, A. M. Wolf, A. Hillenbrand and U. Knippschild, "Gene expression levels of Casein kinase 1 (CK1) isoforms are correlated to adiponectin levels in adipose tissue of morbid obese patients and site-specific phosphorylation mediated by CK1 influences multimerization of adiponectin", Mol Cell Endocrinol, vol. 406, no. C, pp. 87-101, 2015.
DOI:10.1016/j.mce.2015.02.010
Datei:https://www.ncbi.nlm.nih.gov/pubmed/25724478
44.
J. Theiss-Suennemann, K. Jorss, J. J. Messmann, S. D. Reichardt, E. Montes-Cobos, F. Lühder, J. P. Tuckermann, A. W. H, R. Dressel, H. J. Grone, G. Strauss and H. M. Reichardt, "Glucocorticoids attenuate acute graft-versus-host disease by suppressing the cytotoxic capacity of CD8(+) T cells", J Pathol, vol. 235, no. 4, pp. 646-55, 2015.
DOI:10.1002/path.4475
Datei:https://www.ncbi.nlm.nih.gov/pubmed/25358639
43.
S. Vettorazzi, C. Bode, L. Dejager, L. Frappart, E. Shelest, C. Klassen, A. Tasdogan, H. M. Reichardt, C. Libert, M. Schneider, F. Weih, N. Henriette Uhlenhaut, J. P. David, M. Graler, A. Kleiman and J. P. Tuckermann, "Glucocorticoids limit acute lung inflammation in concert with inflammatory stimuli by induction of SphK1", Nat Commun, vol. 6, pp. 7796, 2015.
DOI:10.1038/ncomms8796
Datei:https://www.ncbi.nlm.nih.gov/pubmed/26183376
42.
S. Häfner, F. Beloncle, A. Koch, P. Radermacher and P. Asfar, "Hyperoxia in intensive care, emergency, and peri-operative medicine: Dr. Jekyll or Mr. Hyde? A 2015 update", Ann Intensive Care, vol. 5, no. 1, pp. 42, 2015.
DOI:10.1186/s13613-015-0084-6
Datei:https://www.ncbi.nlm.nih.gov/pubmed/26585328
41.
J. J. Messmann, T. Reisser, F. Leithauser, M. B. Lutz, K. M. Debatin and G. Strauss, "In vitro-generated MDSCs prevent murine GVHD by inducing type 2 T cells without disabling antitumor cytotoxicity", Blood, vol. 126, no. 9, pp. 1138-48, 2015.
DOI:10.1182/blood-2015-01-624163
Datei:https://www.ncbi.nlm.nih.gov/pubmed/26185131
40.
A. M. Vogl, M. M. Brockmann, S. A. Giusti, G. Maccarrone, C. A. Vercelli, C. A. Bauder, J. S. Richter, F. Roselli, A. S. Hafner, N. Dedic, C. T. Wotjak, D. M. Vogt-Weisenhorn, D. Choquet, C. W. Turck, V. Stein, J. M. Deussing and D. Refojo, "Neddylation inhibition impairs spine development, destabilizes synapses and deteriorates cognition", Nat Neurosci, vol. 18, no. 2, pp. 239-51, 2015.
DOI:10.1038/nn.3912
Datei:https://www.ncbi.nlm.nih.gov/pubmed/25581363
39.
S. Anastasiadou, S. Liebenehm, D. Sinske, C. Reckendorf, B. Moepps, A. Nordheim and B. Knöll, "Neuronal expression of the transcription factor serum response factor modulates myelination in a mouse multiple sclerosis model", Glia, vol. 63, no. 6, pp. 958-76, 2015.
DOI:10.1002/glia.22794
Datei:https://www.ncbi.nlm.nih.gov/pubmed/25639799
38.
S. Häfner, K. Wagner, M. Wepler, J. Matallo, M. Groger, O. McCook, A. Scheuerle, M. Huber-Lang, M. Frick, S. Weber, B. Stahl, B. Jung, E. Calzia, M. Georgieff, P. Möller, P. Dietl, P. Radermacher and F. Wagner, "Physiological and immune-biological characterization of a long-term murine model of blunt chest trauma", Shock, vol. 43, no. 2, pp. 140-7, 2015.
DOI:10.1097/SHK.0000000000000277
Datei:https://www.ncbi.nlm.nih.gov/pubmed/25526372
37.
M. Kalbitz, J. J. Grailer, F. Fattahi, L. Jajou, T. J. Herron, K. F. Campbell, F. S. Zetoune, M. Bosmann, J. V. Sarma, M. Huber-Lang, F. Gebhard, R. Loaiza, H. H. Valdivia, J. Jalife, M. W. Russell and P. A. Ward, "Role of extracellular histones in the cardiomyopathy of sepsis", FASEB J, vol. 29, no. 5, pp. 2185-93, 2015.
DOI:10.1096/fj.14-268730
Datei:https://www.ncbi.nlm.nih.gov/pubmed/25681459
36.
K. Singh, P. Maity, L. Krug, P. Meyer, N. Treiber, T. Lucas, A. Basu, S. Kochanek, M. Wlaschek, H. Geiger and K. Scharffetter-Kochanek, "Superoxide anion radicals induce IGF-1 resistance through concomitant activation of PTP1B and PTEN", EMBO Mol Med, vol. 7, no. 1, pp. 59-77, 2015.
DOI:10.15252/emmm.201404082
Datei:https://www.ncbi.nlm.nih.gov/pubmed/25520316
35.
P. Asfar, M. Singer and P. Radermacher, "Understanding the benefits and harms of oxygen therapy", Intensive Care Med, vol. 41, no. 6, pp. 1118-21, 2015.
DOI:10.1007/s00134-015-3670-z
Datei:https://www.ncbi.nlm.nih.gov/pubmed/25634474
34.
D. Wehner, C. Jahn and G. Weidinger, "Use of the TetON System to Study Molecular Mechanisms of Zebrafish Regeneration", J Vis Exp, no. 100, pp. e52756, 2015.
DOI:10.3791/52756
Datei:https://www.ncbi.nlm.nih.gov/pubmed/26168286

2014

33.
J. Witte, W. Kahler, T. Wunderlich, P. Radermacher, C. Wohlrab and A. Koch, "Dose-time dependency of hyperbaric hyperoxia-induced DNA strand breaks in human immune cells visualized with the comet assay", Undersea Hyperb Med, vol. 41, no. 3, pp. 171-81, 2014.
Datei:https://www.ncbi.nlm.nih.gov/pubmed/24984312
32.
J. A. Vogt, U. Wachter, K. Wagner, E. Calzia, M. Groger, S. Weber, B. Stahl, M. Georgieff, P. Asfar, E. Fontaine, P. Radermacher, X. M. Leverve and F. Wagner, "Effects of glycemic control on glucose utilization and mitochondrial respiration during resuscitated murine septic shock", Intensive Care Med Exp, vol. 2, no. 1, pp. 19, 2014.
DOI:10.1186/2197-425X-2-19
Datei:https://www.ncbi.nlm.nih.gov/pubmed/26266919
31.
O. McCook, P. Radermacher, C. Volani, P. Asfar, A. Ignatius, J. Kemmler, P. Möller, C. Szabo, M. Whiteman, M. E. Wood, R. Wang, M. Georgieff and U. Wachter, "H2S during circulatory shock: Some unresolved questions", Nitric Oxide, vol. 41, pp. 48-61, 2014.
DOI:10.1016/j.niox.2014.03.163
Datei:http://www.ncbi.nlm.nih.gov/pubmed/24650697
30.
K. Geurtzen, F. Knopf, D. Wehner, L. F. Huitema, S. Schulte-Merker and G. Weidinger, "Mature osteoblasts dedifferentiate in response to traumatic bone injury in the zebrafish fin and skull", Development, vol. 141, no. 11, pp. 2225-34, 2014.
DOI:10.1242/dev.105817
Datei:https://www.ncbi.nlm.nih.gov/pubmed/24821985
29.
M. Haffner-Luntzer, A. Heilmann, A. E. Rapp, S. Beie, T. Schinke, M. Amling, A. Ignatius and A. Liedert, "Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice", PLoS One, vol. 9, no. 12, pp. e116282, 2014.
DOI:10.1371/journal.pone.0116282
Datei:https://www.ncbi.nlm.nih.gov/pubmed/25551381
28.
J. L. Eisenbacher, H. Schrezenmeier, B. Jahrsdorfer, C. Kaltenmeier, M. T. Rojewski, T. Yildiz, T. Beyer, A. Erle, D. S. Wiegmann, S. Grassl, R. Hang, S. Korper, M. Wiesneth, M. T. Lotze and R. Lotfi, "S100A4 and uric acid promote mesenchymal stromal cell induction of IL-10+/IDO+ lymphocytes", J Immunol, vol. 192, no. 12, pp. 6102-10, 2014.
DOI:10.4049/jimmunol.1303144
Datei:https://www.ncbi.nlm.nih.gov/pubmed/24795458
27.
C. Lehnert, M. Weiswange, I. Jeremias, C. Bayer, M. Grunert, K. M. Debatin and G. Strauss, "TRAIL-receptor costimulation inhibits proximal TCR signaling and suppresses human T cell activation and proliferation", J Immunol, vol. 193, no. 8, pp. 4021-31, 2014.
DOI:10.4049/jimmunol.1303242
Datei:https://www.ncbi.nlm.nih.gov/pubmed/25217163
26.
Y. Qi, D. Jiang, A. Sindrilaru, A. Stegemann, S. Schatz, N. Treiber, M. Rojewski, H. Schrezenmeier, S. Vander Beken, M. Wlaschek, M. Bohm, A. Seitz, N. Scholz, L. Durselen, J. Brinckmann, A. Ignatius and K. Scharffetter-Kochanek, "TSG-6 released from intradermally injected mesenchymal stem cells accelerates wound healing and reduces tissue fibrosis in murine full-thickness skin wounds", J Invest Dermatol, vol. 134, no. 2, pp. 526-537, 2014.
DOI:10.1038/jid.2013.328
Datei:https://www.ncbi.nlm.nih.gov/pubmed/23921952
25.
D. Wehner, W. Cizelsky, M. D. Vasudevaro, G. Ozhan, C. Haase, B. Kagermeier-Schenk, A. Roder, R. I. Dorsky, E. Moro, F. Argenton, M. Kuhl and G. Weidinger, "Wnt/beta-catenin signaling defines organizing centers that orchestrate growth and differentiation of the regenerating zebrafish caudal fin", Cell Rep, vol. 6, no. 3, pp. 467-81, 2014.
DOI:10.1016/j.celrep.2013.12.036
Datei:https://www.ncbi.nlm.nih.gov/pubmed/24485658

2013

24.
A. Sindrilaru and K. Scharffetter-Kochanek, "Disclosure of the Culprits: Macrophages-Versatile Regulators of Wound Healing", Adv Wound Care (New Rochelle), vol. 2, no. 7, pp. 357-368, 2013.
DOI:10.1089/wound.2012.0407
Datei:https://www.ncbi.nlm.nih.gov/pubmed/24587973
23.
S. Bardehle, M. Krüger, F. Buggenthin, J. Schwausch, J. Ninkovic, H. Clevers, H. J. Snippert, F. J. Theis, M. Meyer-Luehmann, I. Bechmann, L. Dimou and M. Gotz, "Live imaging of astrocyte responses to acute injury reveals selective juxtavascular proliferation", Nat Neurosci, vol. 16, no. 5, pp. 580-6, 2013.
DOI:10.1038/nn.3371
Datei:https://www.ncbi.nlm.nih.gov/pubmed/23542688
22.
F. Seichter, A. Wilk, K. Worle, S. S. Kim, J. A. Vogt, U. Wachter, P. Radermacher and B. Mizaikoff, "Multivariate determination of 13CO2/12CO2 ratios in exhaled mouse breath with mid-infrared hollow waveguide gas sensors", Anal Bioanal Chem, vol. 405, no. 14, pp. 4945-51, 2013.
DOI:10.1007/s00216-013-6824-2
Datei:https://www.ncbi.nlm.nih.gov/pubmed/23503745
21.
S. Saxena, F. Roselli, K. Singh, K. Leptien, J. P. Julien, F. Gros-Louis and P. Caroni, "Neuroprotection through excitability and mTOR required in ALS motoneurons to delay disease and extend survival", Neuron, vol. 80, no. 1, pp. 80-96, 2013.
DOI:10.1016/j.neuron.2013.07.027
Datei:https://www.ncbi.nlm.nih.gov/pubmed/24094105
20.
B. Grotek, D. Wehner and G. Weidinger, "Notch signaling coordinates cellular proliferation with differentiation during zebrafish fin regeneration", Development, vol. 140, no. 7, pp. 1412-23, 2013.
DOI:10.1242/dev.087452
Datei:https://www.ncbi.nlm.nih.gov/pubmed/23462472
19.
S. Sirko, G. Behrendt, P. A. Johansson, P. Tripathi, M. Costa, S. Bek, C. Heinrich, S. Tiedt, D. Colak, M. Dichgans, I. R. Fischer, N. Plesnila, M. Staufenbiel, C. Haass, M. Snapyan, A. Saghatelyan, L. H. Tsai, A. Fischer, K. Grobe, L. Dimou and M. Gotz, "Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected]", Cell Stem Cell, vol. 12, no. 4, pp. 426-39, 2013.
DOI:10.1016/j.stem.2013.01.019
Datei:https://www.ncbi.nlm.nih.gov/pubmed/23561443
18.
N. Hartmann, J. J. Messmann, F. Leithauser, M. Weiswange, M. Kluge, H. Fricke, K. M. Debatin and G. Strauss, "Recombinant CD95-Fc (APG101) prevents graft-versus-host disease in mice without disabling antitumor cytotoxicity and T-cell functions", Blood, vol. 121, no. 3, pp. 556-65, 2013.
DOI:10.1182/blood-2012-04-423392
Datei:https://www.ncbi.nlm.nih.gov/pubmed/23203823
17.
A. Maqbool, M. Lattke, T. Wirth and B. Baumann, "Sustained, neuron-specific IKK/NF-kappaB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging", Mol Neurodegener, vol. 8, pp. 40, 2013.
DOI:10.1186/1750-1326-8-40
Datei:https://www.ncbi.nlm.nih.gov/pubmed/24119288
16.
D. Jiang, Y. Qi, N. G. Walker, A. Sindrilaru, A. Hainzl, M. Wlaschek, S. MacNeil and K. Scharffetter-Kochanek, "The effect of adipose tissue derived MSCs delivered by a chemically defined carrier on full-thickness cutaneous wound healing", Biomaterials, vol. 34, no. 10, pp. 2501-15, 2013.
DOI:10.1016/j.biomaterials.2012.12.014
Datei:https://www.ncbi.nlm.nih.gov/pubmed/23317813
15.
S. Stern, S. Haverkamp, D. Sinske, A. Tedeschi, U. Naumann, S. Di Giovanni, S. Kochanek, A. Nordheim and B. Knöll, "The transcription factor serum response factor stimulates axon regeneration through cytoplasmic localization and cofilin interaction", J Neurosci, vol. 33, no. 48, pp. 18836-48, 2013.
DOI:10.1523/JNEUROSCI.3029-13.2013
Datei:https://www.ncbi.nlm.nih.gov/pubmed/24285890
14.
M. Keuper, I. Wernstedt Asterholm, P. E. Scherer, M. A. Westhoff, P. Möller, K. M. Debatin, G. Strauss, M. Wabitsch and P. Fischer-Posovszky, "TRAIL (TNF-related apoptosis-inducing ligand) regulates adipocyte metabolism by caspase-mediated cleavage of PPARgamma", Cell Death Dis, vol. 4, pp. e474, 2013.
DOI:10.1038/cddis.2012.212
Datei:https://www.ncbi.nlm.nih.gov/pubmed/23348588

2012

13.
C. Ehrnthaller, U. Amara, S. Weckbach, M. Kalbitz, M. Huber-Lang and S. Bahrami, "Alteration of complement hemolytic activity in different trauma and sepsis models", J Inflamm Res, vol. 5, pp. 59-66, 2012.
DOI:10.2147/JIR.S31787
Datei:https://www.ncbi.nlm.nih.gov/pubmed/22879778
12.
A. Dyson, F. Simon, A. Seifritz, O. Zimmerling, J. Matallo, E. Calzia, P. Radermacher and M. Singer, "Bladder tissue oxygen tension monitoring in pigs subjected to a range of cardiorespiratory and pharmacological challenges", Intensive Care Med, vol. 38, no. 11, pp. 1868-76, 2012.
DOI:10.1007/s00134-012-2712-z
Datei:https://www.ncbi.nlm.nih.gov/pubmed/23052956
11.
A. M. Burk, M. Martin, M. A. Flierl, D. Rittirsch, M. Helm, L. Lampl, U. Bruckner, G. L. Stahl, A. M. Blom, M. Perl, F. Gebhard and M. Huber-Lang, "Early complementopathy after multiple injuries in humans", Shock, vol. 37, no. 4, pp. 348-54, 2012.
DOI:10.1097/SHK.0b013e3182471795
Datei:https://www.ncbi.nlm.nih.gov/pubmed/22258234
10.
A. Kleiman, S. Hübner, J. M. Rodriguez Parkitna, A. Neumann, S. Hofer, M. A. Weigand, M. Bauer, W. Schmid, G. Schutz, C. Libert, H. M. Reichardt and J. P. Tuckermann, "Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages", FASEB J, vol. 26, no. 2, pp. 722-9, 2012.
DOI:10.1096/fj.11-192112
Datei:https://www.ncbi.nlm.nih.gov/pubmed/22042221
9.
M. J. Schmeisser, B. Baumann, S. Johannsen, G. F. Vindedal, V. Jensen, O. C. Hvalby, R. Sprengel, J. Seither, A. Maqbool, A. Magnutzki, M. Lattke, F. Oswald, T. M. Boeckers and T. Wirth, "IkappaB kinase/nuclear factor kappaB-dependent insulin-like growth factor 2 (Igf2) expression regulates synapse formation and spine maturation via Igf2 receptor signaling", J Neurosci, vol. 32, no. 16, pp. 5688-703, 2012.
DOI:10.1523/JNEUROSCI.0111-12.2012
Datei:https://www.ncbi.nlm.nih.gov/pubmed/22514330

2011

8.
A. Sindrilaru, T. Peters, S. Wieschalka, C. Baican, A. Baican, H. Peter, A. Hainzl, S. Schatz, Y. Qi, A. Schlecht, J. M. Weiss, M. Wlaschek, C. Sunderkotter and K. Scharffetter-Kochanek, "An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice", J Clin Invest, vol. 121, no. 3, pp. 985-97, 2011.
DOI:10.1172/JCI44490
Datei:https://www.ncbi.nlm.nih.gov/pubmed/21317534
7.
F. Knopf, C. Hammond, A. Chekuru, T. Kurth, S. Hans, C. W. Weber, G. Mahatma, S. Fisher, M. Brand, S. Schulte-Merker and G. Weidinger, "Bone regenerates via dedifferentiation of osteoblasts in the zebrafish fin", Dev Cell, vol. 20, no. 5, pp. 713-24, 2011.
DOI:10.1016/j.devcel.2011.04.014
Datei:https://www.ncbi.nlm.nih.gov/pubmed/21571227
6.
A. Kohler, H. Geiger and M. Gunzer, "Imaging hematopoietic stem cells in the marrow of long bones in vivo", Methods Mol Biol, vol. 750, pp. 215-24, 2011.
DOI:10.1007/978-1-61779-145-1_15
Datei:https://www.ncbi.nlm.nih.gov/pubmed/21618094
5.
C. Simon, M. Gotz and L. Dimou, "Progenitors in the adult cerebral cortex: cell cycle properties and regulation by physiological stimuli and injury", Glia, vol. 59, no. 6, pp. 869-81, 2011.
DOI:10.1002/glia.21156
Datei:https://www.ncbi.nlm.nih.gov/pubmed/21446038
4.
X. Shang, J. A. Cancelas, L. Li, F. Guo, W. Liu, J. F. Johnson, A. Ficker, D. Daria, H. Geiger, N. Ratner and Y. Zheng, "R-Ras and Rac GTPase cross-talk regulates hematopoietic progenitor cell migration, homing, and mobilization", J Biol Chem, vol. 286, no. 27, pp. 24068-78, 2011.
DOI:10.1074/jbc.M111.226951
Datei:https://www.ncbi.nlm.nih.gov/pubmed/21572048
3.
E. Boda, F. Vigano, P. Rosa, M. Fumagalli, V. Labat-Gest, F. Tempia, M. P. Abbracchio, L. Dimou and A. Buffo, "The GPR17 receptor in NG2 expressing cells: focus on in vivo cell maturation and participation in acute trauma and chronic damage", Glia, vol. 59, no. 12, pp. 1958-73, 2011.
DOI:10.1002/glia.21237
Datei:https://www.ncbi.nlm.nih.gov/pubmed/21956849

2010

2.
K. Baumgart, F. Wagner, M. Groger, S. Weber, E. Barth, J. A. Vogt, U. Wachter, M. Huber-Lang, M. W. Knoferl, G. Albuszies, M. Georgieff, P. Asfar, C. Szabo, E. Calzia, P. Radermacher and V. Simkova, "Cardiac and metabolic effects of hypothermia and inhaled hydrogen sulfide in anesthetized and ventilated mice", Crit Care Med, vol. 38, no. 2, pp. 588-95, 2010.
DOI:10.1097/ccm.0b013e3181b9ed2e
Datei:https://www.ncbi.nlm.nih.gov/pubmed/20095069