Adapting to compromises – Attenuation of Omicron BA.1 in human cardiomyocytes is contrasted by efficient replication of the BA.5 subvariant
A collaboration of CRC 1279 members led to novel insights into differences between SARS-CoV-2 variants and their potential consequences for cardiac injury.
Dan Albers| January 23rd, 2023
Leading an international effort in the fight against Morbus Waldenström
Prof. Dr. Christian Buske receives the Jan Gösta Waldenström lifetime award for his achievements in improving the treatment of Waldenström’s Macroglobulinemia
Dan Albers| December 20th, 2022
Elite Program of the Baden-Württemberg foundation awards Dr. Mirja Harms
For her proposal to unravel the interplay between SARS-CoV-2, aberrant T-cell activation, and endogenous CXCR4 ligands.
Dan Albers| December 08th, 2022
Back to Lake Federsee and direct interaction
After numerous online meetings, almost 70 CRC 1279 members, as well as scientific advisors and guests, clearly enjoyed to meet in-person to present and discuss science at the symposium in Bad Buchau (Oct. 17 and 18).
Prof. Frank Kirchhoff | November 11th, 2022
Double success including a double mechanism
Researchers of CRC 1279 made two interesting discoveries published almost simultaneously in Cell Host and Microbe and Cell on October 14th and 15th, respectively.
Prof. Frank Kirchhoff | September 19th, 2022
CRC 1279 well-represented at the Peptide Therapeutics Forum 2022
Eight members of CRC 1279 participated at the Peptide Therapeutics Forum 2022 of the Swiss Chemical Society at August 25th and 26th in Basel
Prof. Frank Kirchhoff | September 12th, 2022
Science award of the GlaxoSmithKline Foundation for Dr. Konstantin Sparrer
For his studies on how viral pathogens evade immune control, Dr. Konstantin Sparrer received the prestigious 2021 Science Award for Basic Medical Research from the GlaxoSmithKline Foundation.
Prof. Frank Kirchhoff | July 26th, 2022
ERC Advanced Grant for viral traitors
Good news: Prof. Dr. Frank Kirchhoff and his team will receive 2.3 million euros from the European Research Council for uncovering antiviral defense mechanisms.
Dr. Annika Röcker | May 09th, 2022
On the cover: Improving potency and plasma stability of EPI-X4 derivatives
We are happy to announce that our newest cooperative publication made it on the cover page of Bioconjugate Chemistry.
Prof. Frank Kirchhoff & Dr. Mirja Harms | May 04th, 2022
What it takes to cross borders
Members of CRC 1279 show that a single T403R amino acid change allows the Spike protein of the Sarbecovirus RaTG13 to interact with the human SARS-CoV-2 receptor ACE2.
Prof. Frank Kirchhoff & Fabian Zech | December 10th, 2021
Ulm Peptide Researcher participate in Global Health Center for Pandemic Prevention
Members of the CRCR1279 obtained a grant from the DAAD to participate in a Global Health Center for Pandemic Prevention from 2021 to 2025.
Dr. Ludger Ständker | October 10th, 2021
Improving AMPs: Gran1 inhibits Mycobacterium tuberculosis
We evaluated the antimicrobial activity of Gran1 against the major human pathogen Mycobacterium tuberculosis (Mtb) and a panel of clinically relevant non-tuberculous mycobacteria which are notoriously difficult to treat.
By Reiner Noschka | August 10th, 2021
Surprise: SARS-CoV-2 hijacks usually antiviral factors for efficient infection
IFITMs are well-known to restrict numerous viral pathogens. A new study of CRC 1279 members shows that the opposite is the case for SARS-CoV-2, the coronavirus responsible for the current COVID-19 pandemic.
By Dr. Annika Röcker | July 21th, 2021
First general meeting to prepare for the second funding period
On Monday, June 28th, the first general meeting to prepare for the second funding period of SFB 1279 took place.
June 6th, 2021 | Prof. Frank Kirchhoff
Preventing infection without harming: New antiretroviral peptide discovered in human hemofiltrate
Members of the CRC 1279 identified a peptide that blocks HIV and SIV infection without interfering with the physiological function of the cellular entry cofactor.
by Dr. Annika Röcker | January 21, 2021
The ‘CRC 1279 and beyond’ seminar series goes virtual
We are delighted that the ‘CRC 1279 and beyond’ seminar series is continuing virtually. In fact, two recent interesting virtual seminars have proven that the virtual format still allows exciting scientific discussion.
by Kristina Hopfensperger | January 7, 2021
How to ZAP the coronavirus – a host protein prompts degradation of viral RNA
Upon infection with SARS-CoV-2, human cells produce proteins that restrict viral replication. One of them, called ZAP, has now been characterized by members of the Institute of Molecular Virology.
by Dr. Annika Röcker | October 14, 2020
SARS-CoV-2 Nsp1 blocks protein synthesis and innate immune activation
The novel pandemic Coronavirus SARS-CoV-2 is known to effectively evade human immune defenses. In a close collaboration, the team of Prof. Roland Beckman from the LMU Munich and the labs of Dr. Konstantin Sparrer and Prof. Frank Kirchhoff at the Institute of Molecular Virology, Ulm now revealed the molecular details on how the accessory protein Nsp1 of SARS-CoV-2 shuts down the ribosome and consequently major anti-viral defense systems.
by Dr. Konstantin Sparrer | July 23, 2020
HIV-1 manipulates DNA repair to avoid immune sensing and superinfection
Manipulation of the host cell is essential for replication and spread of HIV-1, the causative agent of AIDS. In a collaborative study, the Wiesmüller and Kirchhoff labs specialized in DNA repair and HIV/AIDS, respectively, now discovered that HIV-1 utilizes its accessory factor Vpu to suppress the accumulation and sensing of nuclear viral DNA species as well as superinfection.
by Prof. Frank Kirchhoff | July 22, 2020
SARS-CoV-2 detected in breast milk
The CRC1279 congratulates Prof. Dr. Jan Münch and his team at the Institute of Molecular Virology Ulm on the first publication of the detection of SARS-CoV-2 in human breast milk 1.
by Kristina Hopfensperger | June 19, 2020
Fighting SARS-CoV-2 – Establishing the basis for future therapeutic strategies
Prof. Dr. Frank Kirchhoff and Jun.-Prof. Dr. Daniel Sauter from the Institute of Molecular Virology receive over 900 000 Euro funding from the Federal Ministry of Education and Research (BMBF) for two new SARS-CoV-2 research projects. Congratulations!
by Kristina Hopfensperger | June 12, 2020
CRC 1279 at the 5th German Pharm-Tox Summit
Congratulations to Maximilian Fellermann who received the young researchers award from the Thieme journal ‘Research’ for the ‘Best Short Presentation 2020 in the subject of Toxicology’.
by Kristina Hopfensperger | March 31, 2020
„Fight nCoV“ – gemeinsam für eine Therapie und Impfung gegen SARS-CoV-2
Die Professoren Jan Münch von der Universität Ulm und Thomas Schrader von der Universität Duisburg-Essen beteiligen sich zusammen mit weiteren europäischen Partnern an dem neuen EU-Projekt „Fight nCoV“. Das Ziel der Forschenden ist es, Wirkstoffe gegen das neue Coronavirus zu testen. Einige vielversprechende Kandidaten sind unter anderem die von Profs. Münch und Schrader entwickelten molekularen Pinzetten.
March 26, 2020 | 🔗 schwaebische.de
The essentials of science communication
The relevance of science communication has been steadily increasing during the last years. The CRC1279 invited Dr. Tobias Maier from the National Institute for Science Communication in Karlsruhe to host a workshop in Ulm.
by Kristina Hopfensperger | March 10, 2020
Introducing the new President of the German Society of Experimental and Clinical Pharmacology and Toxicology: Prof. Dr. Holger Barth
The German Society of Experimental and Clinical Pharmacology and Toxicology (DGPT) nominated CRC1279 member Prof. Dr. Holger Barth to be their president for 2020. Prof. Dr. Barth took over the responsibilities from the outgoing president Prof. Dr. Wieland.
by Kristina Hopfensperger | February 10, 2020
Ein Mantel, der Viren gefährlicher macht
Our former colleque Dr. Annika Röcker wrote many articles for the CRC1279 homepage, now she is writing for the German Journal "Spektrum der Wissenschaft" ... in this case about our Swedish collaborators.
by Dr. Annika Röcker | January 10, 2020 | 🔗 Spektrum.de
International CRC1279 symposium at Lake Federsee
At the 22nd and 23rd of October over 60 CRC1279 members and several international experts joined the international CRC1279 symposium in Bad Buchau next to the beautiful lake Federsee.
by Kristina Hopfensperger | November 25, 2019
The proud winners of the Creative Young Investigators Award
The CRC1279 congratulates the Creative Young Investigators Award Winners: Katharina Ernst, Mirja Harms, Dr. Yasser Ruiz-Blanco, Dr. Konstantin Sparrer and Dr. Stephanie Wehrstedt.
by Kristina Hopfensperger | October 15, 2019
Grand visit - Grant accepted
On July 22nd, CRC 1279 welcomed Dr. Beatrice Hahn, a Professor of Medicine at the Perelman School of Medicine in Philadelphia and a leading AIDS researcher worldwide.
by Kristina Hopfensperger | August 19, 2019
No risk, no breakthrough
Congratulations to CRC 1279 project leader Prof. Dr. Martin Plenio! The ‘Deutsche Forschungs-gemeinschaft’ (DFG) recently awarded Prof. Plenio with a Reinhart Koselleck project and will thus support him with about 1.5 million Euro funding within the next five years.
by Kristina Hopfensperger | August 01, 2019
Ceremonial opening of the new Center for Quantum- and Biosciences
The prime minister of Baden Wuerttemberg Winfried Kretschmann and financial secretary Gisela Splett formally handed over the new Center for Quantum- and Biosciences to Ulm University.
by Kristina Hopfensperger | July 12, 2019
Simply the best
Prof. Dr. Holger Barth wins students teaching award for ‘best lecturer’ for his toxicology lecture within the study program of Molecular Medicine at Eberhard Karls University Tübingen.
by Kristina Hopfensperger | June 19, 2019
CRC1279 Students went to Lindemberg
At the feet of the Bavarian Alps and right outside the town of Lindenberg in the Allgäu, the first CRC 1279 student retreat took place on May 16th-17th.
by Mattheo Bosso | June 30, 2019
And the Poster Award goes to … Dr. Janis Müller
Dr. Janis Müller received one of two Poster Prizes at the 29th Annual Meeting of the German Society for Virology (GfV) in Düsseldorf, Germany.
by Kristina Hopfensperger | March 28, 2019
Time to say goodbye… and hello Kristina!
Annika Röcker, so far responsible for Public Relations and Event reports of the CRC homepage, will leave us by the end of March 2019. Luckily, Kristina Hopfensperger will take over.
by Dr. Annika Röcker, Kristina Hopfensperger and Prof. Dr. Frank Kirchhoff
Prof. Holger Barth in action
Together with Prof. Matthias Schwab from the Fischer-Bosch Institute of ClinicaI Pharmacology in Stuttgart, our PI Prof. Holger Barth chairs the 4th German Pharm-Tox Summit.
by Dr. Annika Röcker | March 06, 2019
Much more than Amyloid β
From February 19th to 21th, CRC1279 board member Prof. Dr. Marcus Fändrich, director of the Institute of Protein Biochemistry, chaired the 3rd Meeting on Biophysics of Amyloid Formation.
by Dr. Annika Röcker & Kristina Hopfensperger | March 05, 2019
Online now: Konstantin Sparrer’s research objective
Dr. Konstantin Sparrer had been awarded with a „Young Investigator Fund for Innovative Research Ideas“ of the Schering Stiftung and the Fritz Thyssen Foundation.
by Dr. Annika Röcker | 21.02.2019
“Should I Stay or Should I Go?”
An interdisciplinary team at Ulm University analyzed the DNA binding behavior of the transcription factor serum response factor (SRF) at single-molecule resolution.
by Dr. Annika Röcker | 04.02.2019
About dream teams: Scientist couple explores Host-Microbe interactions
Prof. Hinterleitner and Prof. Meisel from the University of Pittsburgh gave a lunch seminar addressing the topics: “Woman in academia: Transitioning from a postdoc to group leader/professor”
by Dr. Annika Röcker | 14.01.2019
With Bachelor’s degree straight towards PhD
Due to her exceptional performance, she was allowed to start her PhD directly after her undergraduate studies. Lisa is a perfect example for a young, ambitious woman in science!
by Dr. Annika Röcker | 11.01.2019
Biofilms- more than nasty tooth deposit
For the last Monday seminar in November, CRC1279 had the pleasure to welcome Prof. Knut Drescher from the Max-Planck-Institute (MPI) in Marburg.
by Dr. Annika Röcker | 29.12.2018
Janis Müller received the Hans-Heinrich Niemann prize
Congratulations to Dr. Janis Müller for getting the Hans-Heinrich Niemann prize 2018!
by Dr. Annika Röcker | 20.12.2018
Boosting autophagy and career- Konstantin Sparrer awarded with Young Investigator Fund
Dr. Konstantin Sparrer is granted a Young Investigator Fund starting in January 2019 to support his projects.
by Dr. Annika Röcker | 26.11.2018
CRC1279 goes public- “studium generale” and international students
This has been an eventful week for CRC speaker Frank Kirchhoff: he presented HIV/AIDS as well as CRC1279 to the broad audience of “studium generale” and a group of international students.
by Dr. Annika Röcker | 23.11.2018
About knights, progress and construction - our first CRC1279 retreat
Typical weather for a day in November in Ulm- foggy, rainy and a little chilly. Nevertheless, Prof. Frank Kirchhoff warmly welcomed all PIs, PhD students and postdocs involved in CRC1279.
by Dr. Annika Röcker | 13.11.2018
Cord-Michael Becker Prize 2018 goes to Dominik Hotter!
Congratulations to Dr. Dominik Hotter on the Cord-Michael Becker Prize!
by Dr. Annika Röcker | 05.11.2018
Shpol’skii-Rebane-Personov medal and prize for Prof. Fedor Jelezko
In August this year, the first Shpol’skii-Rebane-Personov medal and prize were awarded to Prof. Fedor Jelezko.
by Dr. Annika Röcker | 19.10.2018
Plant-derived antibiotics against multi-resistant bacteria
Pleasant news for Prof. Dr. med. Steffen Stenger (Institute of Medical Microbiology and Hygiene)! The state Baden Württemberg approved funding of a collaborative projects.
by Dr. Annika Röcker | 18.10.2018
Prof. Holger Barth supports NBC protection
We congratulate Prof. Dr. Holger Barth to his appointment to the scientific advisory panel of the research institutes for NBC protection of the medical academy of the Bundeswehr (German Armed Forces)!
by Dr. Annika Röcker | 04.10.2018
Clarissa Read obtains UUG graduation prize
Every year, the Ulmer Universitätsgesellschaft (UUG) awards prizes to outstanding graduates from Ulm University. We congratulate Dr. hum. biol. Clarissa Read (formerly Villinger) to this excellent achievement.
by Dr. Annika Röcker | 20.09.2018
Young researchers realizing innovative ideas
We congratulate Dr. Konstantin Sparrer (Institute of Molecular Virology) and Dr. Stephanie Wehrstedt (Institute for Medical Microbiology and Hygiene) on the approval of 10,000€ (each) for their proposals!
by Dr. Annika Röcker | 20.09.2018
Can a peptide cure chronically infected hepatitis B and D patients?
Although the weather was rather non-inviting, CRC 1279 warmly welcomed Prof. Stephan Urban from Heidelberg University to the first Monday seminar...
by Dr. Annika Röcker | 03.09.2018
New study reveals structural basis of tetherin counteraction
A collaborative study between James H. Hurley's lab in Berkeley and researchers from the Institute of Molecular Virology in Ulm published in volume 174, issue 3 of Cell....
by Dr. Annika Röcker | 18.08.2018
Combining tools to improve anti-cancer activity
Targeting and combating tumors in a more specific and efficient way is a central goal in modern cancer therapy...
by Dr. Annika Röcker | 15.08.2018
Prof. Dr. Guido Silvestri in the CRC Monday Seminar
It has been a special pleasure for CRC 1279 to welcome the respected HIV/AIDS researcher Prof. Dr. Guido Silvestri from the Emory Institute in Atlanta for the last Monday seminar in July...
by Dr. Annika Röcker | 23.07.2018
CRC on board with Nobel laureate
A glamorous touch inhered in the morning of Friday, June 29th when the “MS Sonnenkönigin” took off from Lindau...
by Dr. Annika Röcker | 29.06.2018