Speaker:  Florian Bassermann
Klinikum rechts der Isar, TUM, Munich

Topic:  The ubiquitin proteasome system - implication in the pathophysiology, evolution and therapy of b-cell malignancies.

Host:   Jan Krönke

Prof. Basserman's lab investigates principles of ubiquitin-dependent signaling in fundamental and cancer relevant cellular functions such as cell cycle control, DNA repair, transcription, protein synthesis, cell differentiation and apoptosis. In particular, they investigate how aberrations of these pathways contribute to tumor development and maintenance, having a focus on hematological malignancies such as multiple myeloma and lymphoma. Ultimately, their work aims to identify new therapeutic target structures to guide the development of rationally designed targeted therapies and biomarkers. To achieve these goals, they use an interdisciplinary approach that combines tumor genomics/functional proteomics and cell biology with translational analyses in preclinical mouse models and human tumor samples.